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2002, Number S1

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Arch Cardiol Mex 2002; 72 (S1)

Inflammation and atherosclerosis

Nava A
Full text How to cite this article

Language: Spanish
References: 5
Page: 153-155
PDF size: 43.65 Kb.


Key words:

Atherosclerosis, Inflammation, Lipoproteins.

ABSTRACT

Atherosclerosis is a disease of the large arteries. There are several risk factors, mainly genetic and environmental, associated with atherosclerosis. Recently acquired knowledge has clearly shown that a prominent role is played by several inflammatory mechanisms in the pathogenesis of this disease. Several pro-inflammatory molecules such as LDL, macrophage colony stimulating factor, and adhesion molecules, deserve special mention because of their major role in the inflammatory response that takes place in atherosclerosis.


REFERENCES

  1. Lusis AJ: Atherosclerosis. Nature 2000; 407: 233-241.

  2. Tamminen M, Mottino G, Qiao JH, Breslow JL, Frank JS: Ultrastructure of early lipid accumulation in apoE-deficient mice. Arterioscl Thromb Vasc Biol 1999;19:847-853.

  3. Gimbrone MAJr: Vascular endothelium, hemodynamic forces, and atherogenesis. Am J Pathol 1999; 155: 1-5.

  4. Watson AD, Leitinger N, Navab M, Faull KF, Horkko S, Witzum JL et al: Structural identification by mass spectometry of oxidized phospholipids in minimally low density lipoprotein that induce monocyte/endothelial interactions and evidence of their presence in vivo. J Biol Chem 1997; 271: 13597-13607.

  5. Knowles JW, Reddick RL, Jennette JC, Shesely EG, Smithies O, Maeda N: Enhanced atherosclerosis and kidney disjunction in eNOS (-/-) apoE (-/-) mice are ameliorated by enalapril treatment. J Clin Invest 2000; 105: 451-458.




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Arch Cardiol Mex. 2002;72