medigraphic.com
SPANISH

Revista Cubana de Obstetricia y Ginecología

ISSN 1561-3062 (Electronic)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2021, Number 2

Next >>

Revista Cubana de Obstetricia y Ginecología 2021; 47 (2)

Risk factors associated with early-onset neonatal sepsis

Amador MR, Ballester LI, Campo GA
Full text How to cite this article

Language: Spanish
References: 25
Page: 1-12
PDF size: 484.51 Kb.


Key words:

newborn, neonatal sepsis, neonatology.

ABSTRACT

Introduction: The neonatal sepsis represents a challenge for specialists since the delay in diagnosis and treatment can lead to important sequelae in the newborn, mainly in premature and underweight patients.
Objective: To identify risk factors for the mother and the infant to develop the early-onset neonatal sepsis.
Methods: A descriptive, retrospective study is carried out in newborns who were admitted to the Neonatal Intensive Care Unit at Guanabacoa Gyneco-Obstetric Hospital, in Havana, from January 1, 2016 to December 31, 2018, diagnosed with early onset sepsis. One hundred four newborns made up the sample. The possible maternal risk factors evaluated were time to rupture of membranes, maternal infections, characteristics of delivery, history of newborns with sepsis. For neonatal risk factors, we evaluated sex, weight and gestational age and causative germs.
Results: Vaginal infection in the mother was present in 75%. 90.4% of the newborns, two or more maternal risk factors predominated. Most of the newborns had good weight (53.8%) at birth and they were born at term (66.4%). Microorganisms were isolated in 28.8% of those with two or more risk factors. Staphylococcus aureus was the germ that predominated in 20.2% of the cases.
Conclusions: In most newborns, early sepsis was not proven by microbiological studies. Vaginal infection was identified as a maternal risk factor. Low weight and the preterm newborns were not directly related to sepsis.


REFERENCES

  1. Hernández Pérez ID, Montes de Oca Domínguez M, Causa Palma N, Ruiz Silva MD, González Pimentel D. Caracterización clínico epidemiológica de recién nacidos admitidos por sepsis temprana. Western Regional Hospital, Belice. 2015. Multimed. 2016 Jul [acceso 22/09/2016];20(4):771-83. Disponible en: http://www.revmultimed.sld.cu/index.php/mtm/article/view/274/349

  2. Shah BA, Padbury JF. Neonatal sepsis: an old problem with new insights. Virulence. 2014 Jan [acceso 22/09/2016];5(1):170-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916371/

  3. Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Time for a neonatal-specific consensus definition for sepsis. Pediatr Crit Care Med. 2014 Jul [acceso 22/09/2016];15(6):523-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087075/

  4. Pérez Santana Y, Clemades Méndez AM, Mederos Cabana Y, Navarro Ruíz M, Arbelo Hernández I, Molina Hernández O. Sepsis neonatal grave en una unidad de cuidados intensivos. Rev Cubana Pediatr. 2015 Ene-Mar [acceso 05/06/2015];87(1):50-60. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312015000100007

  5. Pérez OR, Lona JC, Quiles M, Verdugo MA, Ascencio EP, Benítez EA. Sepsis neonatal temprana, incidencia y factores de riesgo asociados en un hospital público del occidente de México. Rev Chil Infectol. 2015 Ago [acceso 22/09/2016];32(4):387-92. Disponible en: https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-10182015000500003

  6. Alessandrini Garaboa N, Sarmiento Portal Y, Marquez Concepción Y, Portal Miranda ME, Vara Cuesta OL. El recién nacido pretérmino con infección de inicio precoz. Rev Ciencias Médicas Pinar del Río. 2015 nov-dic [acceso 22/09/2016];19(6):[aprox. 8 p.]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-31942015000600007

  7. Toro-Moreno AC, Martínez-Sánchez LM, Restrepo-Arango M, Jaramillo-Jaramillo LI. Streptococcus spp. en el embarazo, patología y avances en su detección temprana. Rev Peru Ginecol Obstet. 2016 Abr [acceso 04/12/2017];62(2):209-17. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304-51322016000200009

  8. Dong Y, Speer CP. The role of Staphylococcus epidermidisin neonatal sepsis: Guarding angel or pathogenic devil? International Journal of Medical Microbiolgy. 2014 Jul [acceso 22/09/2016];304(5-6):513-20. Disponible en: https://www.sciencedirect.com/science/article/pii/S1438422114000496?via%3Dihub

  9. Verdecia Charadán A, Antuch Medina N, Rousseaux Lamothe S, Reyes Matos I. Riesgos maternos asociados a la sepsis neonatal precoz. Rev Inf Cient. 2017 Ene [acceso 14/12/2017];96(1):74-83. Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/32/3317

  10. Pérez Rivas RA. Factores de riesgo asociados a sepsis neonatal temprana en recién nacidos del Hospital Alemán Nicaragüense en el período de enero a junio de 2015 [Tesis]. Managua: Universidad Nacional Autónoma de Nicaragua; 2015 [acceso 14/12/2017]. Disponible en: http://repositorio.unan.edu.ni/1545/1/58961.pdf

  11. Ferrer Montoya R, Rodríguez de la Fuente F, Mojena Mojena O. Factores de riesgo de la sepsis en el recién nacido. Mul Med. 2013;17(2):1-9.

  12. Randis T, Polin R, Saade G. Chorioamnionitis: Time for a new approach. Curr Opin Pediatr. 2017;29(2):159-64.

  13. Villarroel Huillca N. Cuidados de enfermería en sepsis neonatal en servicio de neonatología del HRGDV – Abancay [Tesis]. Arequipa: Universidad Nacional de San Agustín de Arequipa; 2017 [acceso 14/12/2017]. Disponible en: http://repositorio.unsa.edu.pe/bitstream/handle/UNSA/2945/ENSvihun.pdf?sequence=1&isAllowed=y

  14. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014 Jan [acceso 17/05/2019];27(1):21-47. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/24396135

  15. Ting JY, Synnes A, Roberts A, Deshpandey A. Association Between Antibiotic Use and Neonatal Mortality and Morbidities in Very Low-Birth-Weight Infants Without Culture-Proven Sepsis or Necrotizing Enterocolitis. JAMA Pediatr. 2016;170(12):1181-7. DOI: https://doi.org/10.1001/jamapediatrics.2016.2132

  16. Al-Zahrani AK, Ghonaim MM, Hussein YM, Eed EM, Khalifa AS, Dorgham LS. Evaluation of recent methods versus conventional methods for diagnosis of early-onset neonatal sepsis. J Infect Dev Ctries. 2015;9(4):388-93.

  17. Dong Y, Speer CP. Late-onset neonatal sepsis: recent developments. Arch Dis Child Fetal Neonatal Ed. 2015;100(3):257-63.

  18. Cantey JB. Optimizing the Use of Antibacterial Agents in the Neonatal Period. Paediatr Drugs. 2016;18(2):109-22.

  19. Hsu JF, Chu SM, Huang YC, Lien R, Huang HR, Lee CW, et al. Predictors of clinical and microbiological treatment failure in neonatal bloodstream infections. Clin Microbiol Infect. 2015;21(5):482. e9-17. DOI: https://www.doi.10.1016/j.cmi.2015.01.009

  20. Martinez E, Mintegi S, Vilar B, Martínez MJ, López A, Estibaliz C, et al. Prevalence and predictors of bacterial meningitis in young infants with fever without a source. Pediatr Infect Dis J. 2015 [acceso 17/05/2019];34(5):494-8. Disponible en: https://pdfs.journals.lww.com/pidj/2015/05000/

  21. Rohatgi S, Dewan P, Faridi MM, Kumar A, Malhotra RK, Batra P. Seven versus 10 days antibiotic therapy for culture-proven neonatal sepsis: A randomised controlled trial. J Paediatr Child Health. 2017;53(6):556-62.

  22. Mendoza N, Balasch M, Gonzalez S, Cespedes M, Andreu A, Frick M, et al. Escherichia coli early-onset sepsis: trends over two decades. European Journal of Pediatrics. 2017;176(9):1227-34.

  23. Benitz W, Wynn J, Polin R. Reappraisal of guidelines for management of neonates with suspected early-onset sepsis. J Pediatr. 2015;166(4):1070-4.

  24. Higgins R, Saade G, Polin R, Grobman W, Buhimschi I, Watterberg K, et al. Evaluation and Management of Women and Newborns with a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop. Obstet Gynecol. 2016;127(3):426-36.

  25. Pérez-Camacho P, Pino-Escobar J, Cleves-Luna D, Torres-Mosquera A. Características clínicas y paraclínicas de recién nacidos con sepsis en un hospital nivel IV en Cali, Colombia. Infection. 2018;22(3):141.




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Revista Cubana de Obstetricia y Ginecología. 2021;47