Rubio-Guerra AF, Guerrero-García C, Suárez-Cuenca JA, Durán-Salgado MB, Elizalde-Barrera CI

Language: Spanish
References: 13
Page: 1155-1161
PDF size: 179.01 Kb.

ABSTRACT

Objective: To assess the effect of two antihypertensive drug combinations with losartan on ankle-brachial index (ABI) in hypertensive patients.
Materials and Methods: An experimental study including 60 hypertensive patients who had not reached the therapeutic goal, in whom ankle-brachial index was measured at the beginning and end of the study. Patients were randomized into 2 groups: Group A received losartan plus amlodipine (100/5 mg once a day). Group D, losartan plus hydrochlorothiazide (100/12.5 mg once a day), all patients were evaluated monthly for 6 months (from August 2020 to January 2021). Statistical analysis was done with the Wilcoxon test.
Results: There were included 60 patients. All patients reached a good antihypertensive control, without differences between groups (p ‹ 0.05). Group A had a significant increase in ankle-brachial index, from 1.01 to 1.08 (p = 0.00001), in 9 patients anklebrachial index values were normalized when they crossed over the critical value of 0.9, whereas in Group D, there was a significative reduction in ankle-brachial index, from 1.1 to 0.96 (p ‹ 0.00011), in 7 patients this reduction was beyond 0.9.
Conclusions: Our results show a significantly improvement of ankle-brachial index with the losartan amlodipine combination, and a deleterious effect of the losartan hydrochlorothiazide combination on ankle-brachial index.

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