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2022, Number 3

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Rev Mex Pediatr 2022; 89 (3)

Clinical and histopathological characteristics of adenopathies in pediatrics. 10-year analysis in a private hospital

Guevara-Méndez AV, Hernández-Benítez R, Iglesias-Leboreiro J, Bernárdez-Zapata I

Language: Spanish
References: 14
Page: 95-98
PDF size: 187.12 Kb.


ABSTRACT

Introduction: lymphadenopathy occurs in up to 90% of pediatric patients. In some cases, it is necessary to perform a biopsy to determine the etiological diagnosis, and offer the best therapeutic alternative. This study aims to describe the clinical characteristics of children and adolescents who underwent lymph node biopsy. Material and methods: cross-sectional, descriptive, and retrospective study carried out in a private hospital in Mexico City, in the period 2007-2017. Pediatric patients with adenopathies that required lymph node biopsy were included. Sex, age, characteristics of the adenopathies and histopathological diagnosis were recorded. Results: thirty-seven patients aged between five months and 18 years were studied. In 30 patients (81.1%) the adenopathy location was only in one topographic region, the most frequent being the cervical region (n = 22, 59.4%). In 62.2% (n = 23) the lymph node size was < 2 cm. By histopathology, reactive hyperplasia was the most common diagnosis (n = 19, 51.4%), in addition there were nine patients (24.3%) with infectious problems (viral, bacterial, or parasitic), seven patients (18.9%) had neoplasia (lymphomas, sarcomas, or histiocytosis of Langerhans cells), and three patients had rare pathologies: lymphangioma, dermopathic lymphadenitis, and Castleman's disease. Conclusion: in pediatric patients who require lymph node biopsy due to lymphadenopathy, the most common etiology corresponds to a benign process, and in less than 20% to a neoplastic disease.


REFERENCES

  1. Gómez CE, Giraldo LM, Espinal DA, Hurtado IC. Características clínicas e histológicas de adenopatías en pacientes pediátricos. Rev Chil Pediatr. 2016; 87(4): 255-260. doi: prg/10.1016/j.rchipe.2015.11.007.

  2. Friedmann AM. Evaluation and management of lymphadenopathy in children. Pediatr Rev. 2008; 29(2): 53-60. doi: 10.1542/pir.29-2-53.

  3. Dulin MF, Kennard TO, Leach L, Williams R. Management of cervical lymphadenitis in children. Am Fam Physician. 2008; 78(9): 1097-1098.

  4. Weinstock MS, Patel NA, Smith LP. Pediatric cervical lymphadenopathy. Pediatr Rev. 2018; 39(9): 433-443. Available in: http://pedsinreview.aappublications.org/content/39/9/433

  5. Gaddey HL, Riegel AM. Unexplained lymphadenopathy: evaluation and differential diagnosis. Am Fam Physician. 2016; 94(11): 896-903.

  6. Celenk F, Baysal E, Aytac I, Durucu C, Sari I, Mumbuc S et al. Incidence and predictors of malignancy in children with persistent cervical lymphadenopathy. Int J Pediatr Otorhinolaryngol. 2013; 77(12): 2004-2007. doi: 10.1016/j.ijporl.2013.09.022.

  7. Farndon S, Behjati S, Jonas N, Messahel B. How to use… lymph node biopsy in paediatrics. Arch Dis Child Educ Pract Ed. 2017; 102(5): 244-248. doi: 10.1136/archdischild-2015-309634.

  8. Knight PJ, Mulne AF, Vassy LE. When is lymph node biopsy indicated in children with enlarged peripheral nodes? Pediatrics. 1982; 69(4): 391-396.

  9. Pérez Calleja N, Delgado Moya R, Díaz Martínez J, Lourdes García A. Resultados de la biopsia por aspiración con aguja fina en pacientes pediátricos con adenopatías y otras lesiones palpables. MediCiego. 2006; 12(Supl. 2).

  10. Mehrain P, Moghaddam AM, Tavakol E, Amini A, Moghimi M, Kabir A et al. Mediastinal lymphadenopathy in pediatric tuberculosis in computed tomography scan. Int J Mycobacteriol. 2016; 5 Suppl 1: S242-S243. doi: 10.1016/j.ijmyco.2016.11.019.

  11. Habermann TM, Steensma DP. Lymphadenopathy. Mayo Clin Proc. 2000; 75(7): 723-732. doi: 10.4065/75.7.723.

  12. Slap GB, Brooks JS, Schwartz JS. When to perform biopsies of enlarged peripheral lymph nodes in young patients. JAMA. 1984; 252: 1321-2326.

  13. Shah I, Dani S. Profile of tuberculous cervical lymphadenopathy in children. J Trop Pediatr. 2017; 63(5): 395-398. doi: 10.1093/tropej/fmx001.

  14. Rosenberg TL, Nolder AR. Pediatric cervical lymphadenopathy. Otolaryngol Clin North Am. 2014; 47(5): 721-731. doi: 10.1016/j.otc.2014.06.012.




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