medigraphic.com
SPANISH

MEDICC Review

ISSN 1527-3172 (Electronic)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2021, Number 3-4

<< Back Next >>

MEDICC Review 2021; 23 (3-4)

Improving Ketosis-Prone Type 2 Diabetes Diagnosis in Africa

Álvarez-Aldana D
Full text How to cite this article

Language: English
References: 7
Page: 61-62
PDF size: 137.58 Kb.


Key words:

No keywords

Text Extraction

Diabetes mellitus (DM) is a serious health problem with high— and increasing—prevalence and incidence around the world. Africa, with a considerable communicable disease burden, is not exempt and is facing greater DM risk due to rapid demographic, sociocultural, economic and nutritional changes. According to the International Diabetes Federation, Africa will experience the largest jump in DM prevalence (143%) of all regions over the next 25 years.
As a member of the Cuban medical team working in Luanda, Angola, I’ve repeatedly seen male patients presenting with newonset diabetic ketoacidosis (DKA) without evident precipitating cause. Medical records show these patients are between 40 and 50 years old; during ambulatory follow-up, they sometimes maintain good metabolic control despite having discontinued insulin therapy due to dramatic decline in glycemia. These clinical findings suggest the presence of ketosis-prone type 2 diabetes (KPD). Unfortunately, this variant of type 2 diabetes is often not considered during diagnosis and can lead to misclassification and incorrect treatment protocols.


REFERENCES

  1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al.Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation DiabetesAtlas, 9th edition. Diabetes Res Clin Pract. 2019 Nov;157:107843. DOI:10.1016/j.diabres.2019.107843. Epub 2019 Sep 10.

  2. Atun R, Davies JI, Gale EAM, Bärnighausen T, Beran D, Pascal KengneA, et al. Diabetes in sub-Saharan Africa: from clinical care to health policy.Lancet Diabetes Endocrinol Commission [Internet]. 2017 Jul [cited 20 20 Nov5];5(8):622–67. Available at: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(17)30181-X/fulltext

  3. Murunga AN, Owira PMO. Diabetic ketoacidosis: an overlooked child killerin sub-Saharan Africa? Trop Med Int Health [Internet]. 2013 Nov [cited 2021Jun 12];18(11):1357–64. Available at: https://onlinelibrary.wiley.com/doi/full/10.1111/tmi.12195

  4. Ndebele NFM, Naidoo M. The management of diabetic ketoacidosis at a ruralregional hospital in KwaZulu-Natal. Afr J Prim Health Care Fam Med [Internet] .2018 [cited 20 19 Jun 11];10(1):1612. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913763/

  5. Vellanki P, Umpierrez GE. Diabetic ketoacidosis: a common debut of diabetesamong African Americans with type 2 diabetes. Endocr Pract [Internet]. 2017Aug [cited 2021 Jun 12];23(8):971–8. Available a t: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092188/

  6. World Health Organizattion. Classifi cation of diabetes mellitus [Internet].Geneva: World Health Organization; 2019 [cited 2021 Jun 12]. 36 p. Availableat: https://apps.who.int/iris/handle/10665/325182

  7. Umpierrez GE, Smiley D, Kitabchi AE. Narrative review: ketosis-pronetype 2 diabetes mellitus. Ann Intern Med [Internet]. 2006 Mar 7 [cited2020 Nov 5];144(5):350–7. Available at: https://www.acpjournals.org/doi/pdf/10.7326/0003-4819-144-5-200603070-00011




2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

MEDICC Review. 2021;23