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Revista ADM Órgano Oficial de la Asociación Dental Mexicana

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Órgano Oficial de la Asociación Dental Mexicana
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2003, Number 3

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Rev ADM 2003; 60 (3)

Efficacy and safety of bismuth subgalate and salicilate applied as hemostatic agent after third molar extraction

Mora LTA, Trujillo FJJ, Mora SJS
Full text How to cite this article

Language: Spanish
References: 8
Page: 90-94
PDF size: 69.26 Kb.


Key words:

Bismuth subgallate, bismuth subsalicilate, third molars, oral surgery.

ABSTRACT

The subgallate and subsalicilate of bismuth are substances that had been employed as hemostatic agents, in adenotonsillectomies activating the Hageman Factor in coagulation. Question: Are they safe and efficient hemostatic agents after third molar extractions? Purpose: Evaluate the efficiency and safety as hemostatic agents. Hypothesis: They are safe and efficient agents for the bleeding control after third molar extractions. Justification: There isn’t an efficient, safe, easy to obtain and unexpensive agent to help bleeding control. Study design: Randomized placebo-controlled trial. Method: In patients with indication for surgical extractions of the third molars, subgallate or subsalicilate of bismuth was applied topically randomly in each alveolus and a control substance in the contralateral alveolus. Results: The data were analized with the ANOVA parametric test. Seventy one patient were enrolled. Two hundred and eighty four surgical extraction were performed. Seventy one with each of the substances, each one with its control. The group with subgallate and subsalicillate of bismuth obtain the minor time (1.97 min) and the control group obtained the largest (3.52 min) with a statistically significant diference (F = 146.62; p ‹ 0.05). Conclusion: The subgallate and subsalicilate of bismuth are efficient and safe in the bleeding control without adverse effects.


REFERENCES

  1. Thorisdottir H, Ratnoff OD, Maniglia AJ. Activation of Hageman factor (Factor XII) by bismuth subgallate, a hemostatic agent. J Lab Clin Med 1988; 112: 481-486.

  2. Montes De Oca RD y cols. Subsalicilato de bismuto, como agente hemostático en la amigdalectomía de estancia breve. Anales de Otorrinolaringología Mexicana 1991; XXXVI 2: 123-125.

  3. Maniglia AJ, Kushener H, Cozzi L. Adenotonsillectomy: A safe outpatient procedure”. Arch Otolaryngol Head Neck Surg 1989; 115: 92-94.

  4. Callanan V, Curran A, Smyth D et al. The influence of bismuth subgallate and adrenaline paste upon operating time and operative blood loss in tonsillectomy. J Laryngology and Otology 1995; 109: 206-208.

  5. Fenton J, Blayney A, O’dwyer T. Bismuth subgallate–its role in tonsillectomy. J Laryngology and Otology 1995; 109: 203-205.

  6. Maniglia A, Kushner H, Cozzi L. Adenotonsillectomy. Arch Otolaryngol Head Neck Surg 1989; 115: 92-94.

  7. Cozzi L, Magerian C, Dugue C et al. Pulmonary sequelae of intraparenchymal bismuth subgallate. Laringoscope 1992; 102: 597-599.

  8. Hernández S, García C y cols. Estudio comparativo entre 2 agentes hemostáticos en adenoamigdalectomía en un Centro de Cirugía Ambulatoria. ISSSTE 1992.




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Rev ADM. 2003;60