medigraphic.com
ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2021, Number 3

<< Back Next >>

Rev Cubana Hematol Inmunol Hemoter 2021; 37 (3)

Acute promyelocytic leukemia and thrombosis. Presentation of a case

Macia PI, Hernández PC, Quintero SY, Concepción FY, Romero GA, Maxímina RPL

Language: Spanish
References: 14
Page: 1-9
PDF size: 235.35 Kb.


ABSTRACT

Introduction: In recent years it has been proven that the risk of thrombosis in patients with oncohematological diseases has increased.
Case presentation: A 51-year-old male patient, diagnosed with Promyelocytic Leukemia, received induction treatment with arsenic trioxide and the morphological remission of the leukemia had already been achieved and with no personal or family history of thrombotic events, presented a deep vein thrombosis of the left lower limb. He was treated with low molecular weight heparin and warfarin.
Conclusions: The patient progressively had a favorable evolution of the thrombotic event and complete hematological, cytogenetic and molecular remission was achieved with an adequate quality of life that allowed his reinsertion into his personal, family and social life.


REFERENCES

  1. Trousseau A. Phlegmasia alba dolens. En: Bailliere J.B., ed. Clinique Medicale de l´Hotel Dieu de Paris. 2 ed. Paris: JB Bailliere et fills; 1865. p. 654-712.

  2. García Fajardo JD, Martín Rodríguez A, Flores Ramírez I, Musle Acosta M, Pereira Moya C. Características clínicas epidemiológicas de los pacientes con trombosis venosa profunda en los miembros inferiores. MEDISAN [Internet]. 2020 Jun [acceso: 21/02/2021]; 24(3): 443-454. Disponible en: http://scielo.sld.cu/scielo.php?sicript=sci_arttext&pid=S1029.30192020000300443&Ing=es.

  3. Ferreira Bacciarini, J. Trombosis venosa profunda como debut de leucemia aguda. Rev. Méd. Urug. [Internet]. 2018. DOI: https://http://dx.doi.org/10.29193/rmu.34.1.5

  4. Ryan M. Acute Promyelocytic Leukemia: A summary. J Adv Pract Oncol 2018; 9(2):178-87. DOI: https://10.6004/jadpro.2018,9.2.4

  5. Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S, et al. Retinoic acid and arsenic trioxide for Acute Promyelocytic Leukemia. N Engl J Med. 2013; 369(2)2.111-21. DOI: https://10.1056/NEJMoa1300874

  6. Fotiou D, Gerotziafas G, Kastritis E y col. A review of the venous thrombotic issues associated with multiple myeloma. Expert Review of Hematolog. 2016; 9:695-706.

  7. Wu YY, Tang, LI, Wang MH. Leucemia y riesgo de tromboembolismo venoso: un metaanálisis y revisión sistemática de 144 estudios que incluyeron 162, 126 pacientes. Sci Rep. 2017; 1167. DOI: https://doi.org/10.1038/s41598-017-01307-0

  8. Lassaletta A.Leucemias: Leucemia linfoblástica aguda. Pediatr Integ (Internet). 2016 (citado: 14 Dic 2018); 20(6):380-9. Disponible en: https://www.pediatriaintegral.es/numeros-anteriores/publicacion-2012-07/leucemias-leucemias-linfoblastica-aguda/.

  9. Leyto F. Leucemia Mieloide Aguda. Rev Hematol Mex (Internet). 2018; 19(1):24-40.

  10. Dorantes E, Medina A, Dávila K, López B. Clasificación inmunológica de las leucemias agudas linfoblásticas del Hospital Infantil de México Federico Gómez, de acuerdo al EGIL. Gac Mex Oncol (Internet). 2013 [acceso: 17/12/2018];12(3):133-210. Disponible en; https://www.elcevier.es/es-revista-gaceta-mejicana-oncología-305-articulo-clasificacion-inmunologica-las-leucemias-agudas-X1665920113270088.

  11. Albert DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 Revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-405. DOI: https://10.1182/blood-2016-03-643544

  12. Asou N, Adachi K, Tamura J, Kanamura A, Kageyama S, Hiraoka A, et al. Analysis of pronostic factors in newly diagnosed acute promyelocytic leukemia treated whit all-trans retioic acid and chemotherapy. Japan Adult Leukemia Study Group. J Clin Oncol.1998; 16(1):78-85. DOI: https://10.1200/JCO.1998.16.1.78

  13. Ferreira Bacciarini, J. Trombosis venosa profunda como debut de leukemia aguda. Rev. Méd. Urug. (Internet). 2018 (acceso:04/10/2020); 34(1), 113-123. Disponible en: http://www.scielo.edu.uy/scielo.php?script=sci-arttrxt&pid=S1688-03902018000100113&ING=es.http://dx.doi.org/10.29193/rmu.34.1.5.

  14. Falanga A, Marchetti M, Russo L. Venous Thomboembolism in the hematologic malignancies. Curr Opin Oncol 2012; 24(6):702-10.




2020     |     www.medigraphic.com