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2021, Number 3

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Rev Cubana Invest Bioméd 2021; 40 (3)

Mathematical diagnosis of acute myocardial infarction and failure using proportional entropy

Correa HSC, Cuesta RJ, Jattin BJJ

Language: Spanish
References: 29
Page: 1-15
PDF size: 598.03 Kb.


ABSTRACT

Introduction: Physical and mathematical theories have allowed the development of new diagnostic methodologies of cardiac dynamics, as one based on the evaluation of entropy proportions to differentiate normality from cardiac disease, although its diagnostic capacity must be yet determined in specific critical scenarios as acute heart failure and acute myocardial infarction.
Objective: To describe diagnostic evaluations of cardiac dynamics in patients diagnosed with acute myocardial infarction or acute heart failure.
Methods: A blind study was developed with 20 Holter registries; 5 normal, 8 with acute cardiac failure and 7 with acute myocardial infarction. Then, a method based on the proportions of the entropy of the numerical attractors was applied. The maximum and minimum values of the heart rate and the total number of beats per hour were taken for at least 18 hours, with which numerical attractors were generated, which measure the probability of consecutive heart rate pairs. An evaluation of all dynamics was made based on the entropy and its proportions. Finally, a comparison between the diagnostic precision of the mathematical method with respect to the conventional clinical diagnosis was performed.
Results: Normal cases were mathematically differentiated from the pathological ones through the evaluation of Holter registries for 18 hours, achieving values of sensitivity and specificity of 100% as well as a Kappa coefficient of 1, indicating a perfect diagnostic concordance between the mathematical method to diagnose the cardiac dynamics with respect to the clinical diagnosis.
Conclusions: The proportions of entropy allow to establish objective diagnoses of cardiac dynamics, mathematically differentiating normal dynamics from those with acute myocardial infarction and with acute cardiac failure.


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