medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2022, Number 4

<< Back Next >>

Arch Neurocien 2022; 27 (4)

Psychogenic non-epileptic seizures following COVID-19 vaccine: A report of two cases in Colombia

Villalobos-Comas JC, Castillo-Támara EE, Montaño-Lozada JM, Cardona-Moica SM

Language: English
References: 19
Page: 65-69
PDF size: 349.83 Kb.


ABSTRACT

Introduction: The novel coronavirus SARS-CoV-2 has caused the death of more than 5 million of people worldwide. Vaccination is the best strategy for controlling the pandemic with an estimated of more that 4 million of people completely vaccinated. The reported adverse events secondary to vaccines against SARS-CoV-2 are mainly mild and moderate, however, there are raising concerns about more severe and long-term outcomes, as well as neurological complications due to the vaccine.
Methods: We present two cases of psychogenic non epileptiform seizures (PNES) in Colombian female patients following vaccination against COVID-19. There is no evidence of similar adverse reactions reported on the literature.
Discussion and conclusion: We report these events in order to help clinicians in recognizing early and properly all the possible neurological manifestations related to COVID vaccine application, which is aimed to control the current pandemic and its devastating worldwide consequences in terms of health and social issues.


REFERENCES

  1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical featuresof patients infected with 2019 novel coronavirus in Wuhan, China.Lancet. 2020; 395(10223):497-506.

  2. International League Against Epilepsy. COVID-19 vaccines and peoplewith epilepsy. Flower Mound: International League Against Epilepsy.2022 https://www.ilae.org/patient-care/covid-19-and-epilepsy/covid-19-vaccines-and-people-with-epilepsy#English

  3. Food and Drug Administration. Fact sheet for healthcare providersadministering vaccine (vaccination providers). Emergency useauthorization (EUA) of the Moderna COVID-19 vaccine to preventcoronavirus disease 2019 (COVID-19). Maryland: FDA; 2022.https://www.fda.gov/media/144637/download

  4. Food and Drug Administration. Fact sheet for healthcare providersadministering vaccine (vaccination providers). Emergency useauthorization (EUA) of the Pfizer-Biontech COVID-19 vaccineto prevent coronavirus disease 2019 (COVID-19). HealthcareProviders for 12 years of age and older. Maryland: FDA; 2022.https://www.fda.gov/media/153713/download

  5. Fact sheet for healthcare providers administering vaccine (vaccinationproviders). Emergency use authorization (EUA) of the JanssenCOVID-19 vaccine to prevent coronavirus disease 2019 (COVID-19).Warning: thrombosis with thrombocytopenia syndrome. Maryland:FDA; 2022. https://www.fda.gov/media/146304/download

  6. Lin K, Huang H, Fang S, Zheng G, Fu K, Liu N, et al. Shouldpatients with epilepsy be vaccinated against coronavirus disease2019? A systematic review and meta-analysis. Epilepsy Behav.2022;134:108822.

  7. Aladdin Y, Shirah B. New-onset refractory status epilepticusfollowing the ChAdOx1 nCoV-19 vaccine. J Neuroimmunol.2021; 357:577629.

  8. Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, MakheneM, Coler RN, et al. An mRNA Vaccine against SARS-CoV-2 —Preliminary Report. N Engl J Med. 2022; NEJMoa2022483.

  9. Goss AL, Samudralwar RD, Das RR, Nath A. ANA Investigates:Neurological Complications of COVID-19 Vaccines. Ann Neurol.2021; 89(5):856-7.

  10. Ghosh R, Dubey S, Roy D, Mandal A, Naga D, Benito-León J.Focal onset non-motor seizure following COVID-19 vaccination:A mere coincidence? Diabetes Metab Syndr Clin Res Rev. 2021;15(3):1023-4.

  11. Fasano A, Daniele A. Functional disorders after COVID-19vaccine fuel vaccination hesitancy. J Neurol Neurosurg Psychiatry.2022; 93(3):339-40.

  12. Ministerio de Salud y Protección Social. Vacunación contraCOVID-19 [Internet]. Bogotá: Ministerio de Salud y ProtecciónSocial; 2022 [cited 2022 Mar 7]. Available from: https://www.minsalud.gov.co/salud/publica/Vacunacion/Paginas/Vacunacion-covid-19.aspx

  13. World Health Organization. Immunization, vaccines andbiologicals [Internet]. Geneva: World Health Organization; 2022[cited 2022 Mar 7]. Available from: https://www.who.int/teams/immunization-vaccines-and-biologicals

  14. World Health Organization. Background document on the inactivatedvaccine Sinovac-CoronaVac against COVID-19 [Internet]. Geneva:WHO; 2021 [cited 2022 Mar 7]. Available from: https://www.who.int/publications-detail-redirect/WHO-2019-nCoV-vaccines-SAGE_recommendation-Sinovac-CoronaVac-background-2021.1

  15. Espay AJ, Aybek S, Carson A, Edwards MJ, Goldstein LH, HallettM, et al. Current concepts in diagnosis and treatment of functionalneurological disorders. JAMA Neurol. 2018; 75(9):1132.

  16. Marchetti RL, Gallucci-Neto J, Kurcgant D, Proença ICGF,Valiengo L da CL, Fiore LA, et al. Immunization stress-relatedresponses presenting as psychogenic non-epileptic seizuresfollowing HPV vaccination in Rio Branco, Brazil. Vaccine. 2020;38(43):6714-20.

  17. Chen DK, Sharma E, LaFrance WC. Psychogenic non-epilepticseizures. Curr Neurol Neurosci Rep. 2017; 17(9):71.

  18. Reuber M, Jamnadas􁀨Khoda J, Broadhurst M, Grunewald R,Howell S, Koepp M, et al. Psychogenic nonepileptic seizuremanifestations reported by patients and witnesses. Epilepsia.2011; 52(11):2028-35.

  19. Bass C, Halligan P. Factitious disorders and malingering in relationto functional neurologic disorders. Handb Clin Neurol. 2016;139:509-20. doi:10.1016/B978-0-12-801772-2.00042-4




2020     |     www.medigraphic.com