medigraphic.com
SPANISH

Revista Mexicana de Trasplantes

ISSN 2007-6800 (Print)
  • Contents
  • View Archive
  • Information
    • General Information        
    • Directory
  • Publish
    • Instructions for authors        
    • Send manuscript
  • Policies
  • medigraphic.com
    • Home
    • Journals index            
    • Register / Login
  • Mi perfil

2023, Number 1

<< Back Next >>

Rev Mex Traspl 2023; 12 (1)

Corneal tissue preserved in glycerin: an option in times of COVID-19 pandemic

Verdiguel-Sotelo K, Echavarría-Gálvez C, Tello-Medina RI
Full text How to cite this article 10.35366/110000

DOI

DOI: 10.35366/110000
URL: https://dx.doi.org/10.35366/110000

Language: Spanish
References: 30
Page: 30-36
PDF size: 285.46 Kb.


Key words:

corneal transplantation, corneal tissue preserved in glycerin, fresh corneal tissue.

ABSTRACT

Introduction: the COVID-19 pandemic, originating from SARS-CoV-2, has generated a decrease in donation programs. The possibility of transmission is high, therefore fresh corneal tissue is not available. The objective was to document the therapeutic results with the use of corneal tissue preserved in glycerin in patients undergoing emergency corneal transplantation. Material and methods: retrospective, descriptive study. The clinical evolution of the cases treated for corneal transplantation was documented. The records of patients who have undergone emergency corneal transplantation using corneal tissue in glycerin were included. The statistical program SPSS and Excel were used. Results: a total of 19 patients; 13 (68.4%) were male and 6 (13.5%) female. The main indication was infectious corneal ulcer in 7 (36.8%) and perforated in 6 (31.5%) patients. 17 cases (89.4%) achieved the preservation of ocular integrity. Complications included glaucoma 1 (5.3%) and corneal tissue lysis 3 (15.7%). Conclusions: corneal tissue preserved in glycerin is a good option for emergency corneal transplants, as it maintains ocular integrity and saves the eyeball when fresh corneal tissue is not available.


REFERENCES

  1. Li Y, Bai W, Hashikawa T. The neuroinvasive potential of SARS CoV2 may play a role in the respiratory failure of COVID 19 patients. J Med Virol. 2020; 92 (6): 552-555.

  2. Iser BPM, Sliva I, Raymundo VT, Poleto MB, Schuelter-Trevisol F, Bobinski F. Definicao de caso suspeito da COVID-19: uma revisao narrativa dos sinais e sintomas mais frequentes entre os casos confirmados. Epidemiol Serv Saude Brasília, 2020; 29 (3): e2019354.

  3. Dockery DM, Rowe SG, Murphy MA, Krzystolik MG. The ocular manifestations and transmission of COVID-19: recommendations for prevention. J Emerg Med. 2020; 59 (1): 137-140.

  4. Belser JA, Rota PA, Tumpey TM. Ocular tropism of respiratory viruses. Microbiol Mol Biol Rev. 2013; 77 (1): 144-156.

  5. Chen MJ, Chang KJ, Hsu CC, Lin PY, Jui-Ling Liu C. Precaution and prevention of coronavirus disease 2019 infection in the eye. J Chin Med Assoc. 2020; 83 (7): 648-650.

  6. Deng W, Bao L, Gao H, Xiang Z, Qu Y, Song Z et al. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. Nat Commun. 2020; 11 (1): 4400.

  7. Desautels JD, Moshirfar M, Martheswaran T, Shmunes KM, Ronquillo YC. Risks posed to corneal transplant recipients by COVID-19-affected donors. Ophthalmol Ther. 2020; 9 (3): 371-379.

  8. Plan de reactivación de los programas de reactivación de donantes y trasplantes. Centro Nacional de Trasplante México. 2020.

  9. Navarro Martínez-Cantullera A, Calatayud PM. Obtención de tejido corneal para queratoplastia. Arch Soc Esp Oftalmol. 2016; 91 (10): 491-500.

  10. Gain P, Jullienne R, He Z, Aldossary M, Acquart S, Cognasse F et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016; 134 (2): 167-173.

  11. Waldock A, Cook SD. Corneal transplantation: how successful are we? Br J Ophthalmol. 2000; 84 (8): 813-815.

  12. Palamar M, Egrilmez S, Yagci A. Are our cornea waiting lists dynamic enough. Int Ophthalmol. 2016; 36 (2): 195-197.

  13. Garralda A, Epelde A, Iturralde O, Compains E, Maison C, Altarriba M et al. Trasplante de córnea. An Sist Sanit Navar. 2006; 29 (Suppl. 2): 163-173.

  14. Rapuano C. Color atlas and synopsis of clinical ophtalmology Wilms Eye Hospital. 3rd. New York: Wolters Kluwer; 2019.

  15. Kanski J, Bowling B. Oftalmología clinica. 7o. ed. Barcelona: Elsevier; 2012.

  16. Ang M, Mehta JS, Sng CCA, Htoon HM, Tan DTH. Indications, outcomes, and risk factors for failure in tectonic keratoplasty. Ophthalmology. 2012; 119 (7): 1311-1319.

  17. Donoso R, Vargas T. Guías clínicas. Sociedad Chilena de trasplantes; 2011.

  18. Jeng BH. Preserving the cornea: corneal storage media: Curr Opin Ophthalmol. 2006; 17 (4): 332-337.

  19. Kanavi MR, Javadi MA, Chamani T, Fahim P, Javadi F. Comparing quantitative and qualitative indices of the donated corneas maintained in Optisol-GS with those kept in Eusol-C. Cell Tissue Bank. 2015; 16 (2): 243-247.

  20. Thanathanee O, Sripawadkul W, Anutarapongpan O, Luanratanakorn P, SuwanApichon O. Outcome of therapeutic penetrating keratoplasty using glycerol-preserved donor corneas in infectious keratitis. Cornea. 2016; 35 (9): 1175-1178.

  21. Gupta N, Upadhyay P. Use of glycerol-preserved corneas for corneal transplants. Indian J Ophthalmol. 2017; 65 (7): 569-573.

  22. Lin HC, Ong SJ, Chao AN. Eye preservation tectonic graft using glycerol-preserved donor cornea. Eye (Lond). 2012; 26 (11): 1446-1450.

  23. Gupta N, Dhasmana R, Maitreya A, Badahur H. Glycerol-preserved corneal tissue in emergency corneal transplantation: an alternative for fresh corneal tissue in COVID-19 crisis. Indian J Ophthalmol. 2020; 68 (7): 1412.

  24. Shi W, Liu M, Gao H, Li S, Wang T, Xie L. Penetrating keratoplasty with small-diameter and glycerin-cryopreserved grafts for eccentric corneal perforations: Cornea. 2009; 28 (6): 631-637.

  25. Niu G, Zhou Q, Huang X, Wang S, Zhang J, Zhang Y et al. Individualized penetrating keratoplasty using edge-trimmed glycerol-preserved donor corneas for perforated corneal ulcers. BMC Ophthalmol. 2019; 19 (1): 85.

  26. Tripathi H, Mehdi MU, Gupta D, Sen S, Kashyap S, Nag TC et al. Long-term preservation of donor corneas in glycerol for keratoplasty: exploring new protocols. Br J Ophthalmol. 2016; 100 (2): 284-290.

  27. King JH Jr, McTigue JW, Meryman HT. Preservation of corneas for lamellar keratoplasty: a simple method of chemical glycerine-dehydration. Trans Am Ophthalmol Soc. 1961; 59: 194-201.

  28. Moore MB, Gebhardr BM, Verity SM, McDonald MB. Fate of lyophilized xenogeneic corneal lenficules in intrastromal implantation and epikeratophakia. 1987; 28 (3): 555-559.

  29. Feilmeier MR, Tabin GC, Williams L, Oliva M. The use of glycerol-preserved corneas in the developing world. Middle East Afr J Ophthalmol. 2010; 17 (1): 38-43.

  30. Liu X, Zhou Q, Huang X, Liu Z, Bi Y. Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. Medicine (Baltimore). 2016; 95 (39): e4892.




Figure 1
Figure 2
Table 1
Table 2
Table 3

2020     |     www.medigraphic.com

Mi perfil

C?MO CITAR (Vancouver)

Rev Mex Traspl. 2023;12