Rosas-Morett MT, Jurado-Santa CF, Peralta-Pedrero ML, Morales-Sánchez MA

Language: Spanish
References: 8
Page: 75-78
PDF size: 191.32 Kb.

ABSTRACT

Acne is a chronic inflammatory disease that affects the pilosebaceous unit and is among the most common dermatological consultations worldwide. The oral hypoglycemic agent metformin has been shown to have favorable effects in the treatment of acne, acting as an indirect inhibitor of mTORC1, one of the major pathways in acne pathogenesis, with little or no adverse effects. There are recent studies mainly in women with polycystic ovarian syndrome that support the use and efficacy of metformin for the treatment of acne. The present work is the first systematic review of the literature that focuses on the use of metformin as a treatment for moderate to severe acne not caused by hyperandrogenism or polycystic ovarian syndrome.

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