González GI, Martínez EKI, Maldonado LCJ, Calzada RAN

Language: Spanish
References: 13
Page: 189-194
PDF size: 209.38 Kb.

ABSTRACT

Human immunodeficiency virus (HIV) acute phase infection promotes activation of the immunological system, developing a cytokine storm, which contributes to the clinical manifestation of the disease as well as the multi organic dysfunction. The immunological dysregulation promotes the development of autoimmune diseases, by diverse pathophysiological pathways, in case of the immune thrombocytopenia, the production of auto antibodies against the GP IbIX or the GP IIBIIIA explains the mechanism of disease.
Clinical case. 34-year-old female with no previous medical history which presents with thrombocytopenia and petechial lesions is admitted to the Internal Medicine ward in order to be protocolized. During approach she is found to be HIV positive and the cause of thrombocytopenia was due to immune thrombocytopenia, which lead to immediate treatment steroid base as well as acute anti-retroviral therapy, achieving remission of the clinical manifestations. Immune thrombocytopenia is not a rare entity that presents as part as the acute retroviral syndrome in newly diagnosed patients with hiv, therefore is important to consider potential immunological diseases as part of the acute retroviral syndrome in order to improve overall survival, and decrease the likelihood of developing complications of this hemorrhagic syndrome.

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