Ambou FI, Vilches LDC, Gómez CSY, Pérez BA, Osorio IL

Language: Spanish
References: 20
Page: 1-17
PDF size: 408.01 Kb.

ABSTRACT

Objective: Characterize uveitis associated to juvenile idiopathic arthritis.
Methods: A cross-sectional observational descriptive study was conducted based on evaluation of the following variables: age, race, sex, laterality of uveitis, anatomical classification, best corrected visual acuity, presence of complications and treatment.
Results: A predominance was observed of patients aged over six years, female sex and white race. Bilateral uveitis prevailed, with anterior anatomical location. Patients with a best corrected visual acuity ≥ 0.5 stood out for their visual results. The most common complications were visual loss, ocular hypertension and band keratopathy. Most patients had methotrexate associated to topical and oral treatment with steroids.
Conclusion: Uveitis associated to juvenile idiopathic arthritis continues to be an important health problem in childhood, despite the progress in the care of this condition. Therefore, early diagnosis, strict follow-up and appropriate treatment are the pillars of a better evolution.

REFERENCES

1. Giancane G, Consolaro A, Lanni S, Davi S, Schiappapietra B, Ravelli A. Juvenile Idiopathic Arthritis: Diagnosis and Treatment. Rheumatol Ther. 2016;3(2):187-207. DOI: http://doi.org/10.1007/s40744-016-0040-4

2. Aslan M, Kasapcopur O, Yasar H, Polat E, Saribas S, Cakan H, et al. Do infections trigger juvenile idiopathic arthritis? Rheumatol Int. 2011;31(2):215-20. DOI: http://doi.org/10.1186/s12969-018-0265-6

3. Barut K, Adrovic A, Sahin S, Kasapçopur Ö. Juvenile Idiopathic Arthritis. Balkan Med J. 2017;34(2):90-101. DOI: http://doi.org/10.4274/balkanmedj.2017.0111

4. Foster CS, Vitale AT. Diagnosis and Treatment of Uveitis. New Delhi: Jaypee Brothers Medical Publichers; 2013 [acceso: 20/11/2020]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/24050444/

5. Constantin T, Foeldvari I, Anton J, de Boer J, Czitrom-Guillaume S, Edelsten C, et al. Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: the SHARE initiative. Ann Rheum Dis. 2018;77(8):1107-17. DOI: http://doi.org/10.1136/annrheumdis-2018-213131

6. Clarke SL, Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis. Pediat Rheumatol. 2016;14(1):27. DOI: http://doi.org/10.1186/s12969-016-0088-2

7. Lerman MA, Rabinovich E. The Future is Now - Biologics for Non-Infectious Pediatric Anterior Uveitis. Paediatr Drugs. 2015;17(4):283-301. DOI: http://doi.org/10.1007/s40272-015-0128-2

8. Heiligenhaus A, Minden K, Föll D, Pleyer U. Uveitis in juvenile idiopathic arthritis. Dtsch Arztebl Int. 2015;112(6):92-100. DOI: http://doi.org/10.3238/arztebl.2015.0092

9. Heiligenhaus A, Niewerth M, Ganser G, Heinz C, Minden K. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology. 2007;46(6):1015-9. DOI: http://doi.org/10.1093/rheumatology/kem053/

10. Carvounis PE, Herman DC, Cha S, Burke JP. Incidence and outcomes of uveitis in juvenile rheumatoid arthritis, a synthesis of the literature. Graefe´s Arch Clin Exp Ophthalmol. 2006;244(3):281-90. DOI: http://doi.org/10.1007/s00417-005-0087-3

11. Carvounis PE, Herman DC, Cha SS, Burke JP. Ocular manifestations of juvenile rheumatoid arthritis in Olmsted County, Minnesota: a population-based study. Graefes Arch Clin Exp Ophthalmol. 2005;243(3):217-21. DOI: http://doi.org/10.1007/s00417-004-0988-6

12. Saurenmann RK, Levin AV, Feldman BM, Laxer RM, Scheneider R, Silverman ED. Risk of new-onset uveítis in patients with juvenile idiopathic arthritis treated with anti-TNFalpha agents. J Pediatr. 2006;149(6):833-6. DOI: http://doi.org/10.1016/j.jpeds.2006.08.044/

13. Kump LI, Cervantes-Castañeda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005;112(7):1287-92. DOI: http://doi.org/10.1016/j.ophtha.2005.01.044

14. Thorne JE, Woreta F, Kedhar SR, Dunn JP, Jabs DA. Juvenile idiopathic arthritis-associated uveitis: incidence of ocular complications. Am J Ophthalmol. 2007;143(5):840-6. DOI: http://doi.org/10.1016/j.ajo.2007.01.033

15. Asproudis I, Felekis T, Tsanou E, Gorezis S, Karali E, Alfantaki S, et al. Juvenile idiopathic arthritis associated uveitis: Data from a region in western Greece. Clin Ophthalmol. 2010 [acceso: 20/11/2020];4:343-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/20463803/

16. Özdal PC, Vianna RN, Deschênes J. Visual outcomes of juvenile rheumatoid arthritis-associated uveitis in adults. Ocul Immunol Inflamm. 2005;13(1):33-8. DOI: http://doi.org/10.1080/09273940590909220

17. Bolt JB, Cannizzaro E, Seger R, Saurenmann RK. Risk factors and long- term outcome of juvenile idiopathic arthritis-associated uveitis in Switzerland. J Rheumatol. 2008 [acceso: 20/11/2020];35(4):703-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18278829/

18. Gregory II AC, Kempen JH, Daniel E, Kacmaz RO, Foster CS, Jabs DA, et al. Risk factors for loss of visual acuity among patients with uveitis associated with juvenile idiopathic arthritis: The SITE study. Ophthalmology. 2013; 120(1):186-92. DOI: http://doi.org/10.1016/j.ophtha.2012.07.052

19. Heiligenhaus A, Michels H, Schumacher C, Kopp I, Neudorf U, Niehues T, et al. Evidence based, interdisciplinary guidelines for anti- Inflammatory treatment of uveítis associated with juvenile idiopathic arthritis. Rheumatol Int. 2012;32(2):1121-33. DOI: http://doi.org/10.1007/s00296-011-2126-1

20. Constantin T, Foeldvari I, Anton J, de Boer J, Czitrom-Guillaume S, Edelsten C, et al. Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis: The SHAR initiative. Ann Rheum Dis. 2018;77(8):1107-17. DOI: http://doi.org/10.1136/annrheumdis-2018-213131