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ISSN 2007-8013 (Print)
Órgano oficial de la Universidad Autónoma de Sinaloa

2022, Number 4

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Rev Med UAS 2022; 12 (4)

Vitamin D deficiency in patients with severe pre-eclampsia and single-term pregnancy

Carvajal-Sepúlveda AR, Morgan-Ortiz F, Quevedo-Castro E, López-Manjarrez G, Morgan-Ruiz FV, Gutiérrez-Arzapalo PY

Language: Spanish
References: 28
Page: 368-385
PDF size: 264.35 Kb.


ABSTRACT

Preeclampsia is one of the main causes of maternal morbidity and mortality and it is a pregnancy-specific disease characterized by hypertensive disorders that may be associated with different degrees of proteinuria, with the possibility of evolving to different clinical spectrum of severity. In the presence of any of the characteristics marked as “severe”, patients can automatically be classified. The active form of vitamin D plays a regulatory role in the placentation process, usually reaching its vitamin D receptor (VDR Vitamin D Receptor), which is expressed in the trophoblast and decidual tissue depending on the genetic load and patient's endogenous vitamin D synthesis. When there is a decrease in the VDR load, the trophoblast begins to grow and invade in a disorganized manner; however, the invasion doesn’t become functional, since the disorganization causes the lacunar spaces don’t be reached correctly, compromising the oxygen supply of the fetoplacental unit. Those actions trigger a decrease in growth factor type 3 (TGFB3) which induces placental growth, neovascularization and nutrimental output on the invasor trophoblast, contributing to the pathogenesis of preeclampsia.


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