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Revista Médica Sinergia

2023, Number 04

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Revista Médica Sinergia 2023; 8 (04)

Rare causes of amenorrhea due to hypogonadotropic hypogonadism

Castro FM, Gamboa MS, Guevara SMF

Language: Spanish
References: 31
Page:
PDF size: 192.92 Kb.


ABSTRACT

Hypogonadotropic hypogonadism is a clinical syndrome which has diverse acquired and congenital etiologies that may or may not cause primary or secondary amenorrhea and other disorders of puberty. The classification of hypogonadotropic hypogonadism includes multiple diseases which share some abnormality in the hypothalamic-pituitary axis that cause a lowered or null ovarian stimulation.
Regarding the rare congenital causes of hypogonadotropic hypogonadism are included Kallman syndrome, the idiopathic causes which have been being elucidated progressively like the one in CHD7, the mutations in the beta subunits of follicle-stimulating hormone and luteinizing hormone; and the mutation of gonadotropin-releasing hormone receptor. With regard to the acquired causes of amenorrhea due to hypogonadotropic hypogonadism are the pseudocyesis, the peripartum lymphocytic hypophysitis, the chronic non-alcoholic liver disease and chronic kidney disease.


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