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2023, Number 2

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Med Int Mex 2023; 39 (2)

Behind the scenes: ANCA-associated vasculitides and ACR/EULAR 2022 classification criteria

Mercado U
Full text How to cite this article

Language: Spanish
References: 9
Page: 370-376
PDF size: 182.09 Kb.


Key words:

Vasculitis, Anti-neutrophil cytoplasmic antibody associated vasculitis, Classification.

ABSTRACT

What we currently know as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis had previously been recognized in 1923, 1937 and 1951 in autopsies and later renamed microscopic polyangiitis, granulomatosis with polyangiitis (Wegener) and eosinophilic granulomatosis with polyangiitis. In 1954, granulomatosis with polyangiitis (Wegener) was reported for the first time in a clinical journal and in 1964 Alarcon- Segovia included it in its classification. At first, the finding of ANCA in patients with glomerulonephritis with extra-renal manifestations did not attract attention. Van der Woude used them as a diagnostic and monitoring tool for patients with granulomatosis with polyangiitis (Wegener). The Chapel-Hill nomenclature revised in 2012 subdivided small-vessel vasculitides into 2 subtypes: immune complex vasculitis and ANCA-associated vasculitis. In 2022, a group of experts endorsed by the ACR/EULAR developed and validated the classification criteria for these 3 types of ANCA-associated vasculitis.


REFERENCES

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  2. Mercado U. Seventy-five years of microscopic polyangiitiswhathave we learned? J Rheumatol 1999; 10: 2081-2.

  3. Mercado U. La primera descripción clínica de la granulomatosiscon poliangiitis (antes granulomatosis de Wegener).Rev Med Inst Mex Seguro Soc 2017; 55: 380-1.

  4. Mercado U, Arzola E, Sepúlveda R. Lo que deberías conoceracerca de las vasculitis de vasos pequeños asociadas conANCA. Med Int Mex 2021; 37 (5): 827-833. https://doi.org/10.24245/mim.v37i5.4143.

  5. Zeek PM. Periarteritis nodosa. A critical review. Am J ClinPathol 1952; 22: 777-790. doi: 10.1093/ajcp/22.8.777.

  6. Fahey JL, Leonard E, Churg J, Godman G. Wegener’s granulomatosis.Am J Med 1954; 17: 168-79. doi: 10.1016/0002-9343(54)90255-7.

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  8. Lyons PA, James E Peters JE, Federico Alberici F, Liley J,Coulson RMR, et al. Genome-wide association study ofeosinophilic granulomatosis with polyangiitis reveals genomicloci stratified by ANCA status. Nat Commun 2019;10: 5120. https://doi.org/10.1038/s41467-019-12515-9.

  9. Almaani, Fussner LA, Brodsky S, Meara AS, Jayne D. ANCAassociatedvasculitis: An update. J Clin Med 2021; 10: 1-22.doi: 10.3390/jcm10071446.




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Med Int Mex. 2023;39