Flores-Alfaro F, Ramírez-Gutiérrez R, Castillo-Torres SA, Soto-Rincón CA

Language: Spanish
References: 6
Page: 377-379
PDF size: 183.81 Kb.

ABSTRACT

In patients with neuropsychiatric symptoms of subacute onset and seizures for the first time, one of the differential diagnoses to consider is autoimmune encephalitis. Before 2007, these clinical conditions were confused with psychiatric illnesses, even in certain cultures it was thought in cases of demonic possession that required the ritual of exorcism. Autoantibodies against NMDAR, AMPAR, GABABR, LGI1, CASPR 2, mGLUR5, D2R, DPPX, GABAA R, NEUREXIN-3a have been described, but the most commonly recognized disorders are anti-NMDAR encephalitis and limbic encephalitis. Treatment with corticosteroids, plasmapheresis, or immunoglobulins hastens recovery. That is why we highlight the timely suspicion of this disease to start treatment as soon as possible and improve the prognosis.

REFERENCES

1. Blatty WP. El exorcista. México: B de Bolsillo. 2019.

2. Friedkin W. The exorcist. Warner Bros. Pictures, HoyaProductions, 1973.

3. Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z, DalmauJ. Paraneoplastic encephalitis, psychiatric symptoms, andhypoventilation in ovarian teratoma. Ann Neurol 2005; 58(4): 594-604. doi: 10.1002/ana.20614.

4. Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, VoloschinA, Baehring JM, Shimazaki H, Koide R, King D, Mason W,Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitisassociated with ovarian teratoma. Ann Neurol 2007; 61(1): 25-36. doi: 10.1002/ana.21050.

5. Dalmau J, Graus F. Antibody-mediated encephalitis. NEngl J Med 2018; 378 (9): 840-851. doi: 10.1056/NEJMra1708712.

6. Dalmau J, Armangué T, Planagumà J, Radosevic M, MannaraF, Leypoldt F, Geis C, Lancaster E, Titulaer MJ, Rosenfeld MR,Graus F. An update on anti-NMDA receptor encephalitis forneurologists and psychiatrists: mechanisms and models.Lancet Neurol 2019; 18 (11): 1045-1057. doi: 10.1016/S1474-4422(19)30244-3.