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2021, Number 2

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Folia 2021; 15 (2)

Necrobiosis lipoidica: Not always in diabetic patients!

Companioni MY, Gómez DY, González TA

Language: Spanish
References: 11
Page: 1-7
PDF size: 489.71 Kb.


ABSTRACT

Necrobiosis lipoidica is a rare granulomatous disease of unknown etiology. It mainly affects young and middle-aged adults. Diabetes mellitus is a metabolic disease that causes cutaneous manifestations in 94.4% of diabetics and causes necrobiosis lipoidica in 3% of diabetic patients. We present the case of a 45-year-old female patient, with no personal pathological history, who comes to the clinic presenting lesions on her legs for about 10 months, for which she has received multiple treatments without improvement. A skin biopsy was indicated and a diagnosis of necrobiosis lipoidica was confirmed. The importance of presenting this case is due to the rarity of this disease in non-diabetic individuals in our environment.


REFERENCES

  1. Ponce Olivera RM, Moreno Vázquez K, Ubbelohde Henningsen T, Mercadillo Pérez P.Necrobiosis lipoídica en ausencia de diabetes mellitus. Dermatol Rev Mex. 2006; 50:185-8.

  2. Galdeano F, Zaccari S, Parra V, Giannini ME, Salomón S. Manifestaciones cutáneas de ladiabetes mellitus y su importancia clínica. Dermatología Argentina. 2010;16(2).

  3. Fitzpatrik TB, Wolf K, Allen R. Atlas en color y sinopsis de dermatología clínica. 6 ed.Buenos Aires: Editorial Médica Panamericana; 2011. p. 919-33.

  4. Leister L, Korber A, Dissemond J. Successful treatment of a patient with ulceratednecrobiosis lipoidica non-diabeticorum with adalimumab. Hautarzt. 2013;64:509-11.

  5. Borgia F, Vaccaro M, Cantavenera LG. Ulcerative necrobiosis lipoidica successfullytreated with photodynamic therapy: case report and literature review. PhotodiagnosisPhotodyn Ther. 2014;11:516-8. DOI: https://doi.org/10.1016/j.pdpdt.2014.08.002

  6. Jockenhöfer F, Kröger K, Klode J, Renner R, Erfurt-Berge C, Dissemond J. Cofactors andcomorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. Journalder Deutschen Dermatologischen Gesellschaft. 2016;14(3):277-84.

  7. Peckruhn M, Tittelbach J, Elsner P. Update: Therapie der Necrobiosis lipoidica. Journalder Deutschen Dermatologischen Gesellschaft. 2017;15(2):151-8. DOI:https://doi.org/10.1111/ddg.13186

  8. Fitzpatrick JE, High WA, Kyle WL. Annular and targetoid lesions. In: Fitzpatrick JE, HighWA, Kyle WL, eds. Urgent Care Dermatology: Symptom-Based Diagnosis. chap 16.Philadelphia, PA: Elsevier; 2018.

  9. Rosenbach MA, Wanat KA, Reisenauer A, White KP, Korcheva V, White CR. Noninfectiousgranulomas. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. chap 93.4th ed. Philadelphia, PA: Elsevier; 2018.

  10. James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Errors in metabolism.In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseasesof the Skin: Clinical Dermatology. 13th ed. Philadelphia, PA: Elsevier; 2020.

  11. Patterson JW. Weedon's Skin Pathology. chap 8. 5th ed. Philadelphia, PA: Elsevier; 2021.




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