Morales JJ, Sánchez B, Verdejo J, Ponce de LS, Mutchinick OM

Language: Spanish
References: 3
Page: 103-105
PDF size: 42.78 Kb.

ABSTRACT

Hyperhomocysteinemia is considered one of the emerging risk factors for the development of coronary artery disease (CAD). In order to know the prevalence of this metabolic disorder in a Mexican population with early CAD (‹ 50 years), we studied a group of these patients and compared the levels of homocysteine with a group of patients, paired by age and gender, without angiographic evidence of coronary atherosclerosis. Preliminary results show that the population with early CAD has more traditional risk factors, specially diabetes mellitus, and higher levels of homocysteine in plasma. Moreover there is a genetic factor with higher incidence of a TT homozygotic mutation of the MTHFR that increases homocysteine because of an altered folate metabolism.

REFERENCES

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2. Mutchinick OM, Lopez MA, Luna L, Waxman J, Babinsky VE, RYVEMCE Collaborative Group: High Prevalence of the Thermolabile Methylenetetrahydrofolate Reductase Variant in Mexico: A Country with a Very High Prevalence of Neural Tube Defects. Mol Gen Met 1999; 68: 461-7.

3. Stein JH, McBride PE: Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening and treatment. Arch Intern Med 1998; 158: 1301-1306.