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2021, Number 4

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Revista Cubana de Cirugía 2021; 60 (4)

Characterization of patients operated on for Pulmonary Cancer at ''Manuel Ascunce Domenech'' Pulmonary Cancer

García RME, Chávez CMA, García BMJ, Benavidez MA, Koelig PR

Language: Spanish
References: 28
Page: 1-14
PDF size: 456.38 Kb.


ABSTRACT

Introduction: Surgery is the treatment of choice that offers cure to a group of patients affected by pulmonary cancer; yet five-year overall survival for all stages remains low.
Objective: To characterize the patients operated on for pulmonary cancer in the period from March 1, 2015 to August 1, 2020.
Methods: An observational, retrospective and cross-sectional study was carried out to describe the behavior of surgical morbidity and mortality since March 2015 and August 2020 in patients with pulmonary cancer at Manuel Ascunce Domenech University Provincial Hospital in Camagüey City. The study universe was made up of 211 patients operated on with a diagnosis of pulmonary cancer.
Results: There was a predominance of the age 61-70 years and the male sex. Adenocarcinoma and squamous cell carcinoma were the most frequent histological diagnoses. Right upper lobectomy was the most frequently performed resection, as well as some type of mediastinal lymphadenectomy, performed in more than half of the cases. The most frequent complications were those related to air leakage. The death rate was low, with cardiovascular complications and pulmonary thromboembolism being the most frequent causes.
Conclusions: Surgery is the treatment of choice for pulmonary cancer in early stages, with low morbidity and mortality in patients who meet operability conditions.


REFERENCES

  1. Groot PM, Wu CC, Carter BW, Munden RF. The epidemiology of lung cancer. Transl Lung Cancer Res. 2018;7(3):220-33. DOI: https://doi.org/10.21037/tlcr.2018.05.06

  2. Kastner J, Hossain R, White CS. Epidemiology of Lung Cancer. Semin Roentgenol. 2020 Jan;55(1):23-40. DOI: https://doi.org/10.1053/j.ro.2019.10.003

  3. Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med. 2020 Mar;41(1):1-24. DOI: https://doi.org/10.1016/j.ccm.2019.10.001

  4. Wang B, Zhou Y, Jia M, Yan Z, Chen J, Lu X, et al. J. Choice of Treatment for Patients With Non-small-cell Lung Cancer >5 cm Between Surgery Alone and Surgery Plus Adjuvant Radiotherapy. Front Surg. 2021 Mar 9;8:649802. DOI: https://doi.org/10.3389/fsurg.2021.649802

  5. Ehrenstein V, Huang K, Kahlert J, Bahmanyar S, Karlsson P, Löfling L, et al. Outcomes in patients with lung cancer treated with crizotinib and erlotinib in routine clinical practice: A post-authorization safety cohort study conducted in Europe and in the United States. Pharmacoepidemiol Drug Saf. 2021. DOI: https://doi.org/10.1002/pds.5193

  6. Pai E, Kumar T. Evarts Ambrose Graham and the First Successful Pneumonectomy: a Brief Account. Indian J Surg. 2017 Oct;79(5):480-1. DOI: https://doi.org/10.1007/s12262-017-1646-7

  7. Yoo JE, Han K, Shin DW, Park SH, Cho IY, Yoon DW, et al. Conditional relative survival and competing mortality in patients who underwent surgery for lung cancer: A nationwide cohort study. Int J Cancer. 2021 Feb 1;148(3):626-36. DOI: https://doi.org/10.1002/ijc.33239

  8. Khullar O, Wei J, Wagh K, Binongo J, Pickens A, Sancheti M, et al. Preoperative Lung Function is Associated with Patient Reported Outcomes After Lung Cancer Surgery. Ann Thorac Surg. 2020 Oct 29:S0003-4975(20)31814-2. DOI: https://doi.org/10.1016/j.athoracsur.2020.09.016

  9. Marhic A, Dakhil B, Plantefeve G, Zaimi R, Oltean V, Bagan P, et al. Long-term survival following lung surgery for cancer in high-risk patients after perioperative pulmonary rehabilitation. Interact Cardiovasc Thorac Surg. 2019;28(2):235-9. DOI: https://doi.org/10.1093/icvts/ivy225

  10. Sun F, Franks K, Murray L, Lilley J, Wheller B, Banfill K, et al. Cardiovascular mortality and morbidity following radical radiotherapy for lung cancer: Is cardiovascular death under-reported? Lung Cancer. 2020;146:1-5. DOI: https://doi.org/10.1016/j.lungcan.2020.05.004

  11. Demirci NY, Ulger S, Yilmaz U, Aydogdu K, Yilmaz A, Erdogan Y, et al. Radical Oncological Surgery and Adjuvan Therapy in Non- Small Cell Lung Cancer Patients over 70 years of Age. Asian Pac J Cancer Prev. 2015;16(11):4711-4.DOI: http://dx.doi.org/10.7314/apjcp.2015.16.11.4711

  12. Kent M. Lung Cancer Surgery in the Elderly: Age Is Just a Number. Semin Thorac Cardiovasc Surg. 2017;27(17):30300-3. DOI: https://doi.org/10.1053/j.semtcvs.2017.11.010

  13. Davuluri S, Bajpai AK, Thirumurugan K, Acharya KK. The molecular basis of gender disparities in smoking lung cancer patients. Life Sci. 2021;267:118927. DOI: https://doi.org/10.1016/j.lfs.2020.118927

  14. Zeng Q, Vogtmann E, Jia MM, Parascandola M, Li JB, Wu YL, et al. Tobacco smoking and trends in histological subtypes of female lung cancer at the Cancer Hospital of the Chinese Academy of Medical Sciences over 13 years. Thorac Cancer. 2019;10(8):1717-24. DOI: https://doi.org/10.1111/1759-7714.13141

  15. Belot A, Fowler H, Njagi EN, Luque-Fernández MA, Maringe C, Magadi W, et al. Association between age, deprivation and specific comorbid conditions and the receipt of major surgery in patients with non-small cell lung cancer in England: A population-based study. Thorax. 2019 Jan;74(1):51-9. DOI: https://doi.org/10.1136/thoraxjnl-2017-211395

  16. Jia B, Zheng Q, Qi X, Zhao J, Wu M, An T, et al. Survival comparison of right and left side non-small cell lung cancer in stage I-IIIA patients: A Surveillance Epidemiology and End Results (SEER) analysis. Thorac Cancer. 2019;10(3):459-71. DOI: https://doi.org/10.1111/1759-7714.12959

  17. Martin J, Ginsberg RJ, Abolhoda A, Bains MS, Downey RJ, Korst RJ, et al. Morbidity and mortality after neoadjuvant therapy for lung cancer: the risks of right pneumonectomy. Ann Thorac Surg. 2001 Oct;72(4):1149-54. DOI: https://doi.org/10.1016/s0003-4975(01)02995-2

  18. Simón C, Moreno N, Peñalver R, González G, Álvarez-Fernández E, González-Aragoneses F. Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery. The side of pneumonectomy influences long-term survival in stage I and II non-small cell lung cancer. Ann Thorac Surg. 2007 Sep;84(3):952-8. DOI: https://doi.org/10.1016/j.athoracsur.2007.04.075

  19. Zeng Q, Vogtmann E, Jia MM, Parascandola M, Li JB, Wu YL, et al. Tobacco smoking and trends in histological subtypes of female lung cancer at the Cancer Hospital of the Chinese Academy of Medical Sciences over 13 years. Thorac Cancer. 2019;10(8):1717-24. DOI: https://doi.org/10.1111/1759-7714.13141

  20. Pages PB, Mariet AS, Pforr A, Cottenet J, Madelaine L, Abou-Hanna H, et al. Does age over 80 years have to be a contraindication for lung cancer surgery-a nationwide database study. J Thorac Dis. 2018 Aug;10(8):4764-73. DOI: https://doi.org/10.21037/jtd.2018.07.12

  21. Pinsky PF, Lau YK, Doubeni CA. Potential Disparities by Sex and Race-ethnicity in Lung Cancer Screening Eligibility Rates. Chest. 2021:S0012-3692(21)00232-4. DOI: https://doi.org/10.21037/jtd.2018.07.12

  22. Suzuki K. Extended Sleeve Resection for Lung Cancer. Thorac Surg Clin. 2018 Aug;28(3):291-97. DOI: https://doi.org/10.1016/j.thorsurg.2018.03.004

  23. Rodríguez-Martínez OS, García-Rodríguez ME, Concepción-López MA, Rojas-Sánchez JH, Moreno-Perera S. Resultados del tratamiento quirúrgico de pacientes con cáncer pulmonar. Arch Méd Camagüey. 2021 [acceso 31/03/2021];25(1):[aprox. 10 p.]. Disponible en: http://revistaamc.sld.cu/index.php/amc/article/view/7767

  24. Pan L, Mo R, Zhu L, Yu W, Lv W, Hu J, et al. Time trend of mediastinal lymph node dissection in stage IA non-small cell lung cancer patient who undergo lobectomy: a retrospective study of surveillance, epidemiology, and end results (SEER) database. J Cardiothorac Surg. 2020 Aug 1;15(1):207. DOI: https://doi.org/10.1186/s13019-020-01215-x

  25. Tsitsias T, Okiror L, Veres L, King J, Harrison-Phipps K, Routledge T, et al. New N1/N2 classification and lobe specific lymphatic drainage: Impact on survival in patients with non-small cell lung cancer treated with surgery. Lung Cancer. 2021;151:84-90. DOI: https://doi.org/10.1016/j.lungcan.2020.11.005

  26. Guo ZY, Ren JH, Xu YY, Liu RJ, Tao H, Huang J, et al. The significance of systematic lymph node dissection in surgery for early-stage non-small cell lung cancer patients aged =40 years. J Thorac Dis. 2021;13(2):1196-204. DOI: https://doi.org/10.21037/jtd-21-190

  27. Carioli G, Malvezzi M, Bertuccio P, Boffetta P, Levi F, La Vecchia C, et al. European cancer mortality predictions for the year 2021 with focus on pancreatic and female lung cancer. Ann Oncol. 2021;32(4):478-87. DOI: https://doi.org/10.1016/j.annonc.2021.01.006

  28. Seder CW, Basu S, Ramsay T, Rocco G, Blackmon S, Liptay MJ, et al. A Prolonged Air Leak Score for Lung Cancer Resection: An Analysis of The Society of Thoracic Surgeons General Thoracic Surgery Database. Ann Thorac Surg. 2019;108(5):1478-83. DOI: https://doi.org/10.1016/j.athoracsur.2019.05.069




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