Rodríguez GM, Canesín CS, Trujman A

Language: Spanish
References: 5
Page: 28-32
PDF size: 248.51 Kb.

ABSTRACT

Introduction: anal intraepithelial neoplasia (AIN) is a premalignant condition of the anal region, precursor of anal cancer. Develops due to infection with oncogenic strains of human papillomavirus (HPV), its treatment and management will depend on the size of the lesion, location, histology and practice of the colorectal team. Objective: to present our experience in large high-grade AIN. Design: Presentation of two patients and review or current evidence. Material and methods: case 1: 59 year-old woman with prior know genital HPV infection, presents a lesion in the posterior anal margin, scaly with whitish areas, and uneven surface, about 5 cm in diameter with itching; case 2: 38 year-old woman with prior know genital HPV infection, present a lesion of approximately 3 cm in diameter at the posterior anal region, raised, uneven-edged, with itching. Incisional biopsy is taken and reports high grade anal intraepitheliall neoplasia. Results: it is decided to perform surgical resection in both cases. The patients did not present postoperative complications or alterations in fecal continence. The pathological report of the specimen revealed "high grade anal intraepithelial neoplasia, no evidence of invasive carcinoma and free resection margins". Conclusion: these lesions have a low rate of progression to squamous carcinoma. Local and surgical treatment versus clinical follow up has not shown important differences since it has high recurrence rates despite the treatment. However in cases of high grade AIN with symptoms, local resection can be considered.

REFERENCES

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