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Revista de Nefrología, Diálisis y Trasplante

ISSN 0326-3428 (Print)
Órgano de difusión científica de la Asociación Nefrológica de Buenos Aires
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2021, Number 1

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Rev Nefrol Dial Traspl 2021; 41 (1)

Tertiary Hyperparathyroidism as a Manifestation of Bone Mineral Metabolism Disease in Kidney Transplant Recipient: a Diagnostic and Therapeutic Challenge. Presentation of a Clinical Case

Balcázar-Hernández L, Rodríguez MA, Vargas-Ortega G, Mendoza-Zubieta V, González-Virla B
Full text How to cite this article

Language: Spanish
References: 10
Page: 72-78
PDF size: 393.02 Kb.


Key words:

tertiary hyperparathyroidism, kidney transplantation, hypercalcemia, parathyroidectomy.

ABSTRACT

Tertiary hyperparathyroidism (THPT) is characterized by hypercalcemia and autonomous hyperparathyroidism in the context of persistent secondary hyperparathyroidism (SHPT). THPT is related with extraskeletal calcifications, calciphylaxis, fractures, bone pain, progressive loss of bone mineral density, nephrocalcinosis, lithiasis, kidney allograft dysfunction and rejection, neuropsychiatric alterations, cardiovascular disease, and high morbimortality. Subtotal parathyroidectomy is the gold standard for treatment, with high cure rates. We described a case of THPT as a manifestation of Bone Mineral Metabolism Disease after a successful kidney transplant, with an insidious evolution and severe bone damage, with an adequate response to subtotal parathyroidectomy. We evidenced that early diagnosis and treatment of THPT in kidney transplant recipients is essential to the diminution of comorbidities, the improvement of prognosis and the optimization of health resources.


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Rev Nefrol Dial Traspl. 2021;41