medigraphic.com
ISSN 1561-302X (Print)

2021, Number 4

<< Back Next >>

Rev cubana med 2021; 60 (4)

Multiple biliary hamartomatosis

Nodarse PPO, Pérez MR, Velbes MPE

Language: Spanish
References: 22
Page: 1-9
PDF size: 323.77 Kb.


ABSTRACT

Introduction: Multiple biliary hamartomatosis or von Meyenburg complex disease was described by this author in 1955. Its origin is dysembryogenic with a benign and asymptomatic evolutionary course, with normal liver function tests. Imaging studies can confirm the diagnosis, but likewise, when it is a multinodular liver, chronic liver disease can be diagnosed without specifying its etiology, which is why it is essential a histological diagnosis with a directed overlaparoscopic liver biopsy. No specific treatment is needed and its follow-up is semi-annual or annual ultrasound.
Objective: To present the value of laparoscopically directed liver biopsy for multiple biliary hamartomatosis lesions.
Case report: A 53-year-old patient with a history of being a social drinker with a weekly frequency is reported. He was admitted for fever associated with urinary sepsis, in which a fortuitous ultrasound finding of a multinodular liver appeared, without requiring an etiological diagnosis by other imaging studies. This led to a laparoscopy with a liver biopsy aimed at the observed lesions. The histological diagnosis of this entity is confirmed.
Conclusions: The importance and validity of the diagnostic value of laparoscopy, as well as directed liver biopsy to achieve a certain histological diagnosis in this entity, was demonstrated.


REFERENCES

  1. Rodríguez R, Ricote M, Cock I, Iniesta R, Oscullo VR. Hamartomatosis biliar.Euro Eco. 2014[acceso: 28/07/2020];5(4):153-4. Disponible en:http://www.euroeco.org/vol5_num4_dicieb2014/pdf/153_154.pdf

  2. Carabaño I, Herrero M, Sánchez J, Izquierdo E. Hamartomatosis biliar en unalactante con colitis alérgica: revisión a propósito de un caso. Pediatría deAtención Primaria. 2013[acceso: 31/08/2020];15(59):111-4. Disponible en:https://www.researchgate.net/publication/262744154_Hamartomatosis_biliar_en_una_lactante_con_colitis_alergica_revision_a_proposito_de_un_caso

  3. Beltrán Romero LM, Muñiz Grijalvo O, Castell Monsalve FJ. Hamartomatosisbiliar multiple Med Clin (Barc). 2009;132:687.

  4. Mas A, Almirall J, Rodríguez A, Bella R, Corcuera A, Donoso L.Microhamartomatosis of the liver associated with autosomal dominant polycistkidney disease: CT and US appearance. J Comput Assist Tomagr. 1994;18:972-4.

  5. Markhardt BK, Rubens DJ, Huang J. Sonographic features of biliary hamartomaswith histopathologic correlation. J Ultrasound Med. 2006;25:1631-3. DOI:https://doi.org/10.7863/jum2006.25.12.1631

  6. Ishikawa I, Chikamoto E, Nakamura M, Asaka M, Tomosugi N, Yuri T. Highincidence of common bile duct dilatation in autosomal dominant polycystic kidneydisease patients. Am J Kidney Dis. 1996;27:321-26.

  7. Tohme-Noun C, Cazals D, Noun R. Multiple biliary hamartomas: magneticresonance features with histopathologic correlation. Eur Radiol. 2008;18:493-9.

  8. Mortelé K, Ros P. Cystic Focal Liver Lesions in the Adult. Differential CT and MRImaging Features. Radiographics. 2001;21:895-910.

  9. Sustantivo CT, Cazals D, Sustantivo R, Menassa L, Valla D, Vilgrain V. Múltipleshamartomas biliares: características de resonancia magnética con correlaciónhistopatológica. Eur Radiol. 2008;18:493-99.

  10. Mulet AM, Gámez MM. Granulomatosis hepáticas. Eds. Paniagua ME y Piñol FN.En: Gastroenterología y hepatología clínica. cap.159. 2015; La Habana: EditorialCiencia Médicas: 2217-230.

  11. Beck K, Llanio R. Atlas en colores de laparoscopia. 1991. 3ra. ed. La Habana:Editorial Ciencias Médicas. p 168-75.

  12. Tannock IF. Ceell proliferation. In Tannock IF, Hill RP (eds.): The BasicScience of Oncology, 2nd ed. New York. McGraw-Hill; 1992: p 154.

  13. Cotran RS, Kumar V, Collins T. Patología Estructural y Funcional. 6ta. ed.Madrid: McGraw Hill Interamericana; 2015. p 163.

  14. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology, 9na, ed. ElsevierSaunders; 2013. p 163.

  15. Jeon SJ, Yoon SE. Color Doppler twinkling artifact in hepatic bile ducthamartomas (von Meyenburg complexes). J Ultrasound Med. 2006;25:399-402.

  16. Singhal A, Kanagala R, Wright HI, Kohli V. Multiple bile duct hamartomasmimicking diffuse hepatic metastasis: GI image. J Gastrointest Surg.2010;14:1629-31.

  17. Nagano Y, Matsuo K, Gorai K, Sugimori K, Kunisaki C, Ike H, et al. Bile ducthamartomas (von Mayenburg complexes) mimicking liver metastases from bileduct cancer: MRC findings. World J Gastroenterol. 2006;12:1321-3.

  18. Jain D, Ahrens W, Finkelstein S. Molecular Evidence for the NeoplasticPotential of Hepatic Von-Meyenburg Complexes. Appl Immunohistochem MolMorphol. 2010;18:166-71.

  19. Röcken C, Pross M, Brucks U, Ridwelski K, Roessmer A. Cholangiocarcinomaassociated with multiple bile duct hamartomas. Arch Pathol Lab Med. 2000;124:1704-6.

  20. Suchy Frederick KJ. Anatomy, histology, embrilogy developmental anomalies,and Pediatric disorders of biliary tract. In: Feldman M, Fredman LS, Brandt LJ,eds. Sleisenger and Fordtran. Gastrointestinal and liver diseases. 10th. ed. ElsevierSaunders. 2016; cap. 62:1055-1077.e6.

  21. 21 Hasegawa E, Sawa N, Hoshino J, Suwabe T, Hayami N. Recurrent cholangitis ina patient with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Caroli’sdisease. Intern Med. 2016[acceso: 01/8/2020];55:3009-12. Disponible en:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109570/#

  22. Mikolajczyk AE, Te HS, Chapman AB: Gastrointestinal manifestations ofautosomal-dominant polycystic kidney disease. Clin Gastroenterol Hepatol.2017[acceso 1/8/2020]; 15(1):17-24. Disponible en:https://pubmed.ncbi.nlm.nih.gov/27374006/




2020     |     www.medigraphic.com