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ISSN 2448-8011 (Electronic)
Revista de Divulgación del INSTITUTO DE MEDICINA FORENSE de la UNIVERSIDAD VERACRUZANA

2023, Number 1

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Rev Mex Med Forense 2023; 8 (1)

Clinical-Pathological and Molecular Study of the Human Papilloma Virus in Women Carriers of HIV in the municipality of Veracruz

Barragán-Ortiz MA, Torres HRM, González JB, Schettino PMV, Hernández-Romano P, Silva CCS, Denis RP, López-Balderas N

Language: Spanish
References: 24
Page: 107-123
PDF size: 467.73 Kb.


ABSTRACT

Introduction: Human immunodeficiency virus (HIV) and human papillomavirus (HPV), both are some of the most frequent sexually transmitted infections (STIs) worldwide. HPV-HIV coinfection increase the risk of persistent HPV infection and the progression to cancer in a shorter time.
Objective: To analyze the clinical-pathological and molecular characteristics of HPV infection in Veracruz women infected with HIV.
Methodology: 40 HIV positive women between 20 and 65 years old were evaluated. Colposcopy, high-risk HPV detection (subtype 16,18 and high-risk Pool) and liquid-based cytology were performed.
Results: A total of 24 women (60%) clinically presented HPV lesions, 5 cases with multicentric lesions (12.5%), 18 with low-grade squamous intraepithelial lesion (LSIL, 45%), and 1 case of high grade squamous intraepithelial lesion (HSIL, 2.5%). 1 vaginal intraepithelial neoplasia (VAIN, 2.5%), 1 case of invasive cervical cancer (2.5%), 1 case of vulvar cancer (2.5%), 2 vulvar condyloma (5%), 1 anal condyloma (2.5%) were identified. In the molecular tests, 45% (18) were positive for high-risk HPV infection, 37.5% corresponded to the high-risk Pool, 8% to HPV-16, 4% to HPV-18, and 5% of the patients presented more than one viral subtype (HPV-18 + Pool).
Conclusions: The prevalence of lesions and the detection of high-risk HPV in HIV-positive women from Veracruz was higher than in the general population. The most frequent subtype was high-risk Pool.


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