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2021, Number 5

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Rev Ciencias Médicas 2021; 25 (5)

Active ocular toxoplasmosis: current management considerations

Naranjo VBT, León SMA, Ramos LM

Language: Spanish
References: 30
Page: 1-12
PDF size: 391.12 Kb.


ABSTRACT

Introduction: ocular toxoplasmosis is the leading cause of posterior uveitis in the world; it represents a recurrent disorder with fatal consequences for vision.
Objective: to present the different current treatment alternatives in ocular toxoplasmosis.
Methods: a bibliographic search was carried out using national and international medical literature, in electronic and printed format in the open access search engine Google Scholar and the Medline/Pubmed and SciELO databases.
Development: at present there is still no consensus as to the best treatment guideline, therefore the aim of this review is to present the different alternatives according to the national and international medical literature consulted. Its indications are determined by the clinical conditions of the patient: pediatric age, pregnancy, the immune status of the patient, the intensity of the ocular inflammatory condition and the number of recurrences. The therapeutic options are generally carried out with dihydrofolate inhibitors, sulfonamides and steroids.
Conclusions: the purpose of treatment is focused on reducing parasite replication during the active stage and minimizing retinal damage, mainly in lesions affecting the macula. Therefore, it is of interest to know the different alternatives in order to achieve a good visual outcome in patients affected by ocular toxoplasmosis and avoid visual disability or blindness due to this parasitic disease.


REFERENCES

  1. Foster CS, Vitale AT. Diagnosis and treatment of uveitis. Philadelphia: London New York. 2013. https://es.scribd.com/document/280731173/DIAGNOSIS-AND-TREATMENT-OF-UVEITIS

  2. Sánchez R, Sánchez L, Miranda A, Camejo L, Araujo L. La toxoplasmosis observada como un problema no resuelto. Rev Cubana Invest Bioméd [Internet]. 2016 [citado 11/03/2021]; 35(3): 273-83. Disponible en: Disponible en: http://scielo.sld.cu/pdf/ibi/v35n3/ibi06316.pdf .

  3. American Academy of Ophthalmology. Basic and Clinical Science Course 2020-2021. Uveitis and ocular inflammation. San Francisco: American Academy of Ophthalmology; 2020.

  4. Mokua Mose J, Maina Kagira J, Muchina Kamau D, Wangari Maina N, Ngotho M, Muturi Karanja. "A Review on the Present Advances on Studies of Toxoplasmosis in Eastern Africa", BioMed Research International. [Internet]. 2020 [citado 11/03/2021]; (10): 1-12. Disponible en: Disponible en: https://downloads.hindawi.com/journals/bmri/2020/7135268.pdf

  5. Pardo A, Callizo J, Valledeperas X. Revisión de la prevención y tratamiento de la toxoplasmosis ocular. Annals d’Oftalmologia. [Internet]. 2004 [citado 11/03/2021]; 12(1): 11-20.

  6. Estevão DR, Veronese Rodrigues ML, Dinis Costa PA, Bollela Valdes R, Freitas e Silva MS et al. Frequency and visual outcomes of ocular toxoplasmosis in an adult Brazilian population. Scientific Reports. [Internet]. 2021 [citado 11/05/2021]; 11(1): 3420. Disponible en: Disponible en: https://www.researchgate.net/publication/349172307_Frequency_and_visual_outcomes_of_ocular_toxoplasmosis_in_an_adult_Brazilian_population

  7. Pantoja Ramos A, Pérez García L. Reseña histórica acerca de las investigaciones relacionadas con la toxoplasmosis. Rev Cubana Med Trop. [Internet]. 2001 [citado 11/03/2021]; 53(2): 111-17. Disponible en: Disponible en: http://scielo.sld.cu/pdf/mtr/v53n2/mtr08201.pdf .

  8. Smith JR, Ashander LM, Cordeiro CA, Arruda SL, Cordeiro CA, Lie S, et al. Pathogenesis of ocular toxoplasmosis. Sciencedirect. [Internet]. 2020 [citado 11/03/2021]; 81: 100882. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1350946220300549?via%3Dihub .

  9. Facio Lince LA, López de Mesa C, de la Torre A. Toxoplasmosis ocular en Colombia: 10 años de aportes investigativos. Rev Soc Colomb Oftalmol [Internet]. 2018; [citado 11/03/2021]; 51(1): 16-28. Disponible en: Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=7025785

  10. Ozgonul C, Besirli CG. Recent Developments in the Diagnosis and Treatment of Ocular Toxoplasmosis. Ophthalmic Res [Internet]. 2017 [citado 11/03/2021]; 57(1): 1-12. Disponible en: Disponible en: https://www.karger.com/Article/PDF/449169

  11. Brandão-de-Resende C, Babu Balasundaram M, Narain S, Mahendradas P, Vascocelos-Santos DV. Multimodal Imaging in Ocular Toxoplasmosis. Ocul Immunol Inflamm [Internet]. 2020 [citado 08/02/2021]; 28(8): 1196-1204. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/32160073/

  12. Ferrer Mellor T, Sevilla Pérez B, Lacorzana J, Bravo Mancheño B, García Serrano JL. Novedades para el diagnóstico de la toxoplasmosis ocular usos de la tomografía de coherencia óptica. Anales de pediatría [Internet]. 2020 [citado 08/02/2021]; 92(2): 105-106. Disponible en: Disponible en: https://www.analesdepediatria.org/es-novedades-el-diagnostico-toxoplasmosis-ocular-articulo-S1695403319301754

  13. Garwed JG, Pleyer U. Treament Strategy in Human Ocular toxoplasmosis: Why antibiotics Have Failed. J. Clin Med [Internet]. 2021 [citado 08/05/2021]; 10(5): 1090. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961948/

  14. Sameer AM, Al-Khars WI. Ocular toxoplasmosis related macular traction: A case report and review of the literature. Saudi Journal of Ophthalmology [Internet]. 2019 [citado 08/02/2021]; 33(1): 84-7. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/pii/S1319453418302704

  15. Rio Torres M, Fernández Argones L, Hernández Silva JR, Ramos López M. Oftalmología. Diagnóstico y tratamiento. 2da ed. La Habana: Editorial Ciencias Médicas; 2018. https://es.scribd.com/doc/222067405/Manual-de-Diagnostico-y-Tratamiento-Oftalmologico-Completo

  16. Simsek M, Ozdal PC, Kocer AM. Optic nerve involvement in ocular toxoplasmosis: 12 year data from a tertiary referral center in Turkey. Arq Bras Oftalmol [Internet]. 2019 [citado 08/02/2021]; 82(4): 302-9. Disponible en: Disponible en: https://pdfs.semanticscholar.org/5576/7b6b4cd104230e06ee449d2e3002cefcc080.pdf?_ga=2.206860437.703511590.1632562921-2108700542.1632455430

  17. Kandwala N, Besirli CG. Ocular toxoplasmosis: a refrecher. San Francisco: American Academy of Ophthalmology; 2020. https://www.aao.org/eyenet/article/ocular-toxoplasmosis-a-refresher

  18. Calvo Barbado DM, Delgado Martínez I. Formulario nacional de medicamentos. La Habana: Editorial Ciencias Médicas; 2014. https://instituciones.sld.cu/hospmiguelenriquez/files/2018/01/Formulario-nacional-de-medicamentos.pdf

  19. Soheilian M, Sadoughi MM, Ghajarnia M, Behboudi H, Anisian A, Peyman GA, et al. Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis. Ophthalmology. [Internet]. 2005 [citado 08/02/2021]; 112(11):1876-82. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0161642005008870 .

  20. Díaz Valle D, Méndez Fernández R, Benítez del Castillo Sánchez JM. Actualización en el tratamiento de las uveítis. Las Palmas de Gran Canaria: Mac Line S.L [Internet]. 2007 [citado 08/02/2021]. Disponible en: Disponible en: https://docplayer.es/10438427-Actualizacion-en-el-tratamiento-de-las-uveitis.html

  21. Opremcak EM, Scales DK, Sharpe MR. Trimethropim-sulfamethoxazole therapy for ocular toxoplasmosis. Ophthalmol. [Internet]. 1992 [citado 20/04/2021]; 99(6):920-5. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0161642092318731

  22. Dunay IR, Gajurel K, Dhakal R, Liesenfeld O, Montoya JG. Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice. Clin Microbiol Rev. [Internet]. 2018 [citado 20/04/2021]; 31(4): e00057-17. Disponible en: Disponible en: https://journals.asm.org/doi/epub/10.1128/CMR.00057-17 .

  23. Zuluaga LM, Hernández JC, Castaño CF, Hernando Donado J. Efecto del tratamiento prenatal con espiramicina en la frecuencia de retinocoroiditis por toxoplasmosis congénita en una cohorte colombiana. Biomédica [Internet]. 2017 [citado 06/04/2021]; 37(1): [aprox. 7 p.]. Disponible en: Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/2818/3453

  24. Jasper S, Vedula SS, John SS, Horo S, Sepah YJ, Nguyen QD. Corticosteroids as adjuvant therapy for ocular toxoplasmosis. Cochrane Database Syst Rev. [Internet]. 2017 [citado 20/04/2021]; 1(1): CD007417. Disponible en: Disponible en: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007417.pub3/epdf/full .

  25. Shammaa AM, Powel TG, Benmerzouga I. Adverse outcomes associated with the treatment of Toxoplasma infections. Neurology. [Internet]. 2021 [citado 20/04/2021]; 96(15 supl.):1035. Disponible en: Disponible en: https://n.neurology.org/content/96/15_Supplement/4261 .

  26. Soheilian M, Ramezani A, Azimzadeh A, Sadoughi MM, Dehghan MH, Shahghadami R, et al. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine and prednisolone treatment of ocular toxoplasmosis. Ophthalmology [Internet]. 2011; [citado 20/04/2021]; 118(1):134-41. Disponible en: Disponible en: https://www.aaojournal.org/article/S0161-6420(10)00448-3/pdf

  27. Lashay A, Mirshahi A, Parandin N, Riazi H, Masloumi M, Reza M, et al. A prospective randomized trial of azithromycin versus trimethropim-sulfamethoxazole in treatment of toxoplasmic retinochoroiditis. Journal of Current Ophthalmology [Internet]. 2017 [citado 20/04/2021]; 29(2):120-5. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/pii/S2452232516300488 .

  28. Yates WB, Chiong F, Zagora S, Post JJ, Wakefield D, McCluskey P. Ocular Toxoplasmosis in a Tertiary Referral Center in Sydney Australia-Clinical Features, treatment, and Prognosis. Asia Pac J Ophthalmol (Phila) [Internet]. 2019 [citado 20/02/2021]; 8(4):280-4. Disponible en: Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6727929/ .

  29. Casoy J Nascimento H, Silva LMP, Fernández-Zamora Y, Muccioli C, Dias JRO. Effectiveness of Treatments for Ocular Toxoplasmosis. Ocul Immunol Inflamm [Internet]. 2020 [citado 20/02/2021]; 28(2):249-55. Disponible en: Disponible en: https://doi.org/10.1080/09273948.2019.1569242 .

  30. Ramos Gómez EA, Pérez Tejeda A, Hernández Baguer R, Linares Guerra M, Bueno Arrieta Y, et all. Toxoplasmosis ocular y rehabilitación visual. Presentación de un caso. Rev haban cienc méd [Internet]. 2013 [citado 20/04/2021]; 12(1): 48-56. Disponible en: Disponible en: http://scielo.sld.cu/scielo.php?pid=S1729-519X2013000100006&script=sci_arttext&tlng=en




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