Semería LMF, Díaz CAR, Gerardo HM, Rendón MME, Silva RH, Bernárdez ZI, Reyes HJ

Language: Spanish
References: 9
Page: 328-332
PDF size: 153.03 Kb.

ABSTRACT

Introduction: in order to establish whether administering acetylsalicylic acid (ASA) in pregnant women with risk factors for preeclampsia impacts the prevention of low birth weight in their child, we analyzed two retrospective cohorts of mother-child data, one with an indication of ASA intake (100 mg C/24 h) and a control group without management. The birth weight of the newborns was reviewed, and their weight-for-gestational-age status (low < 10th percentile) was established. The risk was established by odds ratios adjusted for confounding variables. Results: 131 neonates born to mothers who received ASA were included, of whom 73 were low birth weight (55.7%, 95% CI 46.8-64.4%) and 277 controls with 125 low birth weight neonates (45.1%, 95% CI 39.2-51.2%). Fetal exposure to ASA increased the risk of low birth weight 1.7 times (95% CI 1.1-2.88), adjusted for sex, gestational age, maternal age, presence of preeclampsia, and/or maternal hypertension. Conclusion: our data indicate that administering ASA in mothers at risk of preeclampsia could harm fetal growth.

REFERENCES

1. Roberge S, Nicolaides K, Demers S, Hyett J, Chaillet N, Bujold E. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol. 2017; 216 (2): 110-120.e6.

2. Choi YJ, Shin S. Aspirin prophylaxis during pregnancy: a systematic review and meta-analysis. Am J Prev Med. 2021; 61 (1): e31-e45.

3. Story L, Nelson-Piercy C. Aspirin versus placebo in pregnancies at high risk for preterm pre-eclampsia. Obstet Med. 2018; 11 (2): 90-91.

4. Atallah A, Lecarpentier E, Goffinet F, Doret-Dion M, Gaucherand P, Tsatsaris V. Aspirin for prevention of preeclampsia. Drugs. 2017; 77 (17): 1819-1831.

5. Godínez V, Godínez-Vázquez VJ, Godínez-Vázquez PR et al. Prevención de la preeclampsia con ácido acetilsalicílico. Rev Med Inst Mex Seguro Soc. 2019; 57 (5): 270-276.

6. Young BC, Thadhani R, Karumanchi SA. Aspirin to prevent preterm preeclampsia: more progress. Hypertension. 2020; 75 (4): 941-942.

7. Jurado-García E. El crecimiento intrauterino. Bol Med Hosp Infant Mex. 1970; 27 (2): 225-249.

8. Van Doorn R, Mukhtarova N, Flyke IP, Lasarev M, Kim K, Hennekens CH et al. Dose of aspirin to prevent preterm preeclampsia in women with moderate or high-risk factors: A systematic review and meta-analysis. PLoS One. 2021; 16 (3): e0247782.

9. Roberge S, Bujold E, Nicolaides KH. Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis. Am J Obstet Gynecol. 2018; 218 (3): 287-293.e1.