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2021, Number 6

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Revista Habanera de Ciencias Médicas 2021; 20 (6)

Hemophagocytic syndrome secondary to dengue virus infection

Andres PJ, Fiesco SK, Medina RG

Language: Spanish
References: 19
Page: 1-5
PDF size: 410.44 Kb.


ABSTRACT

Introduction: Hemophagocytic syndrome is a severe clinical picture with an uncontrolled inflammatory reaction caused by an inadequate immune system response to an infectious, neoplastic, rheumatological, or metabolic trigger. The syndrome has low incidence but high fatality when the management is not adequate.
Objective: To highlight the importance of a prompt diagnosis of hemophagocytic syndrome in patients with dengue who present a torpid evolution.
Case presentation: Seven-year-old patient with severe dengue caused by shock, hepatomegaly with elevated transaminase levels and poor clinical evolution who meets hemophagocytic syndrome criteria. The patient had satisfactory progression after receiving immunomodulatory treatment.
Conclusions: Hemophagocytic syndrome must be considered as a cause of pathologies in dengue patients with torpid evolution, even when correct medical management is made.


REFERENCES

  1. Instituto Nacional de Salud. Semana epidemiológica 52 (22 al 28 de diciembre de 2019) [Internet]. Colombia:Boletín Epidemiológico Semanal; 2019 [Citado 13/02/2021]. Disponible en: https://www.ins.gov.co/buscadoreventos/BoletinEpidemiologico/2019_Boletin_epidemiologico_semana_52.pdf

  2. Rosenberg ML, Echavarría GL, Ludueña AV, Estrada G, Molina MM, Rosenberg L. Hemofagocitosis secundaria adengue. MEDICINA (Buenos Aires) [Internet]. 2018 [Citado 13/02/2021];78(1):37-40. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802018000100008

  3. Morel Z, Ramírez A. Respuesta autoinmune en niños con dengue. Reporte de casos. Reumatología Clínica[Internet].2014;10(4):257-9. Disponible en: http://doi.org/10.1016/j.reuma.2013.07.005

  4. Rueda E, Méndez A, González G. Síndrome hemofagocítico asociado con dengue hemorrágico. Biomédica[Internet].2002;22(2):160. Disponible en: http://doi.org/10.7705/biomedica.v22i2.1155

  5. Koshy M, Mishra AK, Agrawal B, Kurup AR, Hansdak SG. Dengue fever complicated by hemophagocytosis. OxfordMedical Case Reports [Internet]. 2016;2016(6):121-4. Disponible en: http://doi.org/10.1093/omcr/omw043

  6. Al Samkari H, Berliner N. Hemophagocytic Lymphohistiocytosis. Annual Review of Pathology: Mechanisms of Disease[Internet].2018;13(1):27-49. Disponible en: http://doi.org/10.1146/annurev-pathol-020117-043625

  7. Astigarraga I, González Granado LI, Allende LM, Alsina L. Síndromes hemofagocíticos: la importancia del diagnósticoy tratamiento precoces. Anales de Pediatría [Internet].2018;89(2):124.e1-124.e8. Disponible en: http://doi.org/10.1016/j.anpedi.2018.05.003

  8. Henter JI, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: Diagnostic and therapeuticguidelines for hemophagocytic lymphohistiocytosis. Pediatric Blood Cancer [Internet].2007;48(2):124-31. Disponibleen: http://doi.org/10.1002/pbc.21039

  9. Dávila Duponta D, López IR de la P. Síndrome hemofagocítico. Reporte de un caso y revisión de la literatura.Revista de la Facultad de Medicina [Internet]. 2019;62(2):15-21. Disponible en: http://doi.org/10.22201/fm.24484865e.2019.62.2.04

  10. Hein N, Bergara GH, Moura NBV, Cardoso DM, Hirose M, Ferronato AE, et al. Dengue fever as a cause ofhemophagocytic lymphohistiocytosis. Autopsy and Case Reports [Internet].2015;5(3):33-6. Disponible en: http://doi.org/10.4322/acr.2015.016

  11. Hadinegoro SRS. The revised WHO dengue case classification: does the system need to be modified?.Paediatrics and International Child Health [Internet]. 2012;32(Sup1):33-8. Disponible en: http://doi.org/10.1179/2046904712Z.00000000052

  12. Harapan H, Michie A, Sasmono RT, Imrie A. Dengue: A Minireview. Viruses [Internet]. 2020;12(8):[Aprox. 2 p].Disponible en: http://doi.org/10.3390/v12080829

  13. Brisse E, Wouters CH, Andrei G, Matthys P. How viruses contribute to the Pathogenesis of HemophagocyticLymphohistiocytosis. Frontiers in Immunology [Internet].2017;8:1102. Disponible en: http://doi.org/10.3389/fimmu.2017.01102

  14. Giang HTN, Banno K, Minh LHN, Trinh LT, Loc LT, Eltobgy A, et al. Dengue hemophagocytic syndrome: A systematicreview and meta‐analysis on epidemiology, clinical signs, outcomes, and risk factors. Reviews in Medical Virology[Internet].2018;28(6):1-11. Disponible en: http://doi.org/10.1002/rmv.2005

  15. Rosado FGN, Kim AS. Hemophagocytic Lymphohistiocytosis. American Journal of Clinical Pathology[Internet].2013;139(6):713-27. Disponible en: http://doi.org/10.1309/AJCP4ZDKJ4ICOUAT

  16. Wan Jamaludin WF, Periyasamy P, Wan Mat WR, Abdul Wahid SF. Dengue infection associated hemophagocyticsyndrome: Therapeutic interventions and outcome. Journal of Clinical Virology [Internet].2015;69:91-5. Disponible en:http://doi.org/10.1016/j.jcv.2015.06.004

  17. Raju S, Kalyanaraman S, Swaminathan K, Nisha A, Praisid S. Hemophagocytic Lymphohistiocytosis Syndrome inDengue Hemorrhagic Fever. The Indian Journal of Pediatrics [Internet].2014;81(12):1381-3. Disponible en: http://doi.org/10.1007/s12098-014-1425-4

  18. Ellis EM, Sharp TM, Pérez Padilla J, González L, Poole Smith BK, Lebo E, et al. Incidence and Risk Factors forDeveloping Dengue-Associated Hemophagocytic Lymphohistiocytosis in Puerto Rico, 2008 - 2013. PLOS NeglectedTropical Diseases [Internet].2016;10(8):e0004939. Disponible en: http://doi.org/10.1371/journal.pntd.0004939

  19. Kan FK, Tan CC, Von Bahr Greenwood T, Khalid KE, Supramaniam P, Hed Myrberg I, et al. Dengue InfectionComplicated by Hemophagocytic Lymphohistiocytosis: Experiences From 180 Patients With Severe Dengue. ClinicalInfectious Diseases [Internet].2020;70(11):2247-55. Disponible en: http://doi.org/10.1093/cid/ciz499




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