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2022, Number 1

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Revista de Ciencias Médicas de la Habana 2022; 29 (1)

Use of serum lactate as a prognostic biomarker in patients with sepsis in Intensive Care

Hernández OM, Fernández CI, Ávila MI, Hernández JA

Language: Spanish
References: 20
Page: 22-31
PDF size: 702.00 Kb.


ABSTRACT

Sepsis is one of the main causes of morbidity and mortality in Intensive Care, it causes organic and tissue hypo-perfusion dysfunction.
Objective: To evaluate the use of serum lactate, as an individual prognostic biomarker, in patients admitted with sepsis in Intensive Care.
Methods: An observational, cross-sectional and retrospective study was carried out in patients admitted with sepsis, at ¨Aleida Fernández Chardiet¨ Teaching Clinical Surgical hospital, in 2019. The population under study was formed by 121 patients.
Results: Lactate values behaved differently among the population which was not able to survive (p˂0.001). The area under the curve for lactate was of a 71 %. The presence of 3 or more organs in dysfunction, 20.7 %, (p≤0.001) they were related to the levels of lactate, as well as the prognostic scales. Acute Physiology and Chronic Health Evaluation system score II≥15 (˂0.001), Simplified Acute Physiology Score 3≥50 (˂0.001) and the Sequential Organ Failure Assessment≥4 (˂0.001). the medium blood pressure had an average of 90±19 mmHg, with difference among their medium values with respect to lactate that resulted significant (p˂0.001). The base deficit was related to the lactate in contrast with their figures (p=0.002). Lactate ≥2.2 mmol/L as only variable, had a higher risk of death (OR=6.4, IC95 % 2.9 al 14.1, p˂0.001).
Conclusions: This study considers that the serum lactate ≥ 2.2 mmol/L constitutes an individual prognostic bio-marker, in patients admitted with sepsis, in Intensive Care.


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