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2021, Number 3

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Invest Medicoquir 2021; 13 (3)

Clinical characteristics of congenital syndrome associated with Zika virus infection

Ortega PMÁ, González GJ, Maragoto RC, Galvizu SR, Zaldivar BM, Pubillones E
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Language: Spanish
References: 16
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Key words:

zika virus, zika virus infection, neurological malformations.

ABSTRACT

Introduction: The congenital syndrome associated with the Zika virus (CZS), described in the last decade, has constituted a health problem for the countries of Latin America. This disease is manifested by microcephaly and a series of fetal malformations that mainly involve the central nervous system, and generates severe functional alterations in children who suffer from it.: To describe the clinical characteristics in children diagnosed with CZS who were treated at the International Center for Neurological Restoration (CIREN), in the period from August/2018 to December/2020. Methods: We carried out a prospective descriptive study in a series of 14 children with a diagnosis of CZS, all from Venezuela admitted to our center through the Cuba-Venezuela Health Agreement, treated in the period from August/2018 to December/2020, who were evaluated by a multidisciplinary team. Results: 100% of the patients presented the main neurological alterations described in the CSZ as microcephaly, delayed psychomotor development and spasticity. 85.71% of the children presented epilepsy. 100% of the patients presented structural brain lesions present in CSZ such as: reduction of the brain, thin cortex, ventriculomegaly, hypoplasia of the corpus callosum, subcortical calcifications. Conclusions: It is found that the congenital syndrome associated with Zika virus infection causes serious neurological sequelae.


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Invest Medicoquir. 2021;13