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ISSN 2007-6800 (Print)

2023, Number 4

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Rev Mex Traspl 2023; 12 (4)

Factors related to renal graft function at the first and third year of follow-up at the Naval Medical Center

Valadez-Trujillo JA, Rojas-Rodríguez FO, Arellano-Llamas MR, Hernández-Rivera JCH

Language: Spanish
References: 16
Page: 193-198
PDF size: 255.10 Kb.


ABSTRACT

Introduction: kidney transplant (RT) is the best renal replacement therapy in patients with end-stage chronic kidney disease as it offers a better quality of life for the recipient and leads to a lower socio-health cost. Objective: to identify the factors related to delayed graft function (DGF) and to determine the functionality of the renal graft at the first and third year of follow-up at the Naval Medical Center in Mexico. Material and methods: retrospective cohort of patients with RT carried out between 2012 and 2019. 33 records of patients with RT were analyzed. DGF and graft survival at the first and third year of follow-up were analyzed as outcomes. For graft survival, the Kaplan-Meier method was used. Logistic regression was used to predict the risk factors related to DGF with a significance p < 0.05. SPSS version 21 was used. Results: the functionality at the first and third year was 97% and 92%, respectively. The risk factors associated with DGF were the deceased donor with an OR of 9.0 (95% CI 1.126-71.958, p = 0.038) and induction therapy with thymoglobulin OR of 10.5 (95% CI 1.558-70.762, p = 0.016). Conclusions: the factors associated with DGF were deceased donor and induction with thymoglobulin, assuming that the risk of presenting DGF is not related to the drug, but to the context in which it is administered, since these patients were identified as high-risk patients immunological.


REFERENCES

  1. Webster A, Nagler E, Morton R, Masson P. Chronic kidney disease. Lancet. 2017; 389 (10075): 1238-1252.

  2. Abbas AK, Lichtman A, Pillai S. Inmunología celular y molecular. 8va. Ed. Barcelona, España: Elsevier Inc.; 2017. p. 365.

  3. Terapia Inmunosupresora en el Trasplante Renal, México: Instituto Mexicano del Seguro Social, 2009. Disponible en: http://www.imss.gob.mx/profesionales/guiasclinicas/gpc.htm

  4. Tratamiento sustitutivo de la función renal. Diálisis y hemodiálisis en la insuficiencia renal crónica. México: Instituto Mexicano del Seguro Social; 25 de septiembre de 2014.

  5. Foroutan F, Friesen E, Clark K et al. Risk factors for 1-year graft loss after kidney transplantation systematic review and meta-analysis. Clin J Am Soc Nephrol. 2019; 14 (11): 1642-1650.

  6. Guirado L, Oppenheimer F. Traplante renal de donante vivo. En: Lorenzo V, López Gómez JM (eds). Nefrología al día. ISSN: 2659-2606. Disponible en: https://www.nefrologia aldia.org/235. Sociedad Española de Nefrología. 2022.

  7. Valjalo R, Reynolds E, Herrera P, Espinoza O, Gonzalez, F. Resultados a largo plazo en trasplante renal de donantes con criterios expandidos. Rev Med Chile. 2016; 144: 22-29.

  8. Ticona A, Álvarez L, Jimenez A, Cruz J et al. Supervivencia del paciente e injerto renal al año de trasplante de donante fallecido; comparación con resultados de donante vivo. Rev Mex Urol 2010; 70 (6): 347-353.

  9. Leyva-de-la-Torre C, Hernández-Vázquez L, Capote-Pereira L et al. Necrosis tubular agudo y rechazo agudo y su impacto en la función del injerto renal. Revista Cubana de Urología. 2019; 8 (1): 8. Disponible en: https://revurologia.sld.cu/index.php/rcu/article/view/468

  10. Almeida E, Silveira M, De Araújo V et al. Gender in the allocation of organs in kidney transplants: meta-analysis. Rev Saúde Pública 2015; 49: 68.

  11. Ayala M, Diaz E, Soel J et al. Supervivencia de los pacientes receptores de trasplante renal. Gaceta Médica de México. 2020; 156: 34-39.

  12. Gómez M. Análisis de los factores que determinan la supervivencia del injerto a largo plazo en el trasplante renal con donantes en asistolia no controlada fallecidos en la calle o en su domicilio. Universidad Complutense de Madrid. 2019.

  13. Bahla D, Haddad Z, Datoo A, Oazi Y. Delayed graft function in kidney transplantation. Curr Opin Organ Transplant. 2019; 24 (1): 82-86-

  14. Melih K, Basak B, Mustafa C, Nilgun A. Incidence, risk factors, and outcomes of delayed graft function in deceased donor kidney transplantation. Transplant Proc. 2019; 51 (4): 1096-1100.

  15. Hernández J, Espinoza R, Cruz J et al. Funcionalidad del injerto renal a 1 año del trasplante renal. Cirugía y Cirujanos. 2022; 90 (1): 90-99.

  16. Benítez D, Godoy G, Miño C et al. Características de los pacientes trasplantados renales con retraso de la función del injerto, asistidos en el servicio de terapia intensiva del Instituto de Cardiología de Corrientes entre 2016 y 2018. Notas de Enfermería. 2020; 20 (35): 5-12.




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