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2023, Number 3

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Rev Med UAS 2023; 13 (3)

Therapeutic benefits of hyperbaric oxygen therapy in diabetic nephropathy: Clinical evidence and perspectives

Gomez-Solis MNE, Ramírez-Nava JC, Salas-Nolasco OI, Romero-Martínez BS, Flores-Soto E

Language: Spanish
References: 16
Page: 288-297
PDF size: 519.14 Kb.


ABSTRACT

Objective: Diabetic nephropathy (DN) represents a serious complication of diabetes mellitus (DM), characterized by the progressive loss of kidney function. In recent years, hyperbaric oxygen therapy (HBO2) has emerged as an innovative therapeutic option to address this complex condition. This article evaluates and analyzes the effects of HBO2 on key markers of ND, highlighting its clinical implications and future perspectives. Material and Methods: The study included patients in stages 3 and 4 of ND and consisted of the administration of 20 sessions of HBO2 at 2.3 ATA in a hyperbaric chamber. Measurement of glycosylated hemoglobin (HbA1c) estimated, glomerular filtration rate (eGFR) and albumin/creatinine ratio were carried out and clinical stages were stratified before and after treatment with HBO2. Results: Before starting treatment with HBO2, patients presented initial values of HbA1c, eGFR, serum creatinine and albuminuria, and the urine albuminuria/creatinine index of 8.12 ± 0.29 %, 38.68 ± 1.79 ml/min/1.73 m2, 1.85 ± 0.09 mg/dL, 131.47 ± 11.78 mg/l, y 78.74 ± 8.17 mg/g, respectively. After treatment, the values were 7.2 ± 0.25%, 53.16 ± 2.58 ml/min/ 1.73 m2, 1.47 ± 0.07 mg/dL, 117.56 ± 11.35 mg/l y 82.12 ± 8.52 mg/g, respectively. Conclusions: HBO2 is emerging as a promising adjuvant therapy for ND, with demonstrated positive effects on key markers and the potential to improve patient care by providing new hope and approaches in treatment.


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