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2024, Number 1

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Acta Pediatr Mex 2024; 45 (1)

Iatrogenic Cushing's syndrome and steroid withdrawal syndrome due to the use of topical steroids

Jaime SMA

Language: Spanish
References: 9
Page: 27-33
PDF size: 322.25 Kb.


ABSTRACT

Background: Topical steroids represent one of the main pillars in the treatment of many dermatological diseases, thanks to their anti-inflammatory and antiproliferative effects. If applied properly, they are safe and effective; however, prolonged exposure can cause serious side effects.
Clinical case: We present the case of a 1-year-and-7-month-old female patient who developed iatrogenic Cushing's syndrome and steroid withdrawal syndrome due to chronic and unsupervised use of topical steroids in the diaper area.
Conclusions: Topical corticosteroids are an excellent tool for the treatment of multiple skin conditions. Knowledge of your use is essential; therefore, knowing your indications and your profile of safety is essential for daily pediatric practice.


REFERENCES

  1. Hengge UR, Ruzicka T, Schwartz RA, Cork MJ. Adverseeffects of topical glucocorticosteroids. J Am Acad Dermatol 2006; 54(1): 1-15.

  2. Lodish M. Cushing's syndrome in childhood: update ongenetics, treatment, and outcomes. Curr Opin EndocrinolDiabetes Obesity 2015; 22 (1): 48-54.

  3. Socorro CD, Tristá SET, Torres ER, García YG. Glucocorticoiddeprivation syndrome. Rev Cubana Endocrinol 2015; 25(3): 198-205.

  4. Wolosky OC, de Ocariz MS, Ordiales LL. Esteroides tópicos:revisión actualizada de sus indicaciones y efectos adversosen dermatología. Dermatol Cosmét Méd Quirúrg 2015; 13(4): 305-313.

  5. Morán-Villaseñor E, Palacios-López C, Sáez de Ocariz M,Orozco-Covarrubias L, et al. Síndrome de Cushing iatrogénicoy sarna costrosa por uso de esteroides tópicos. Actaped Méx 2018; 39 (2): 172-178.

  6. Karwoski CB. Postmarketing Safety Review – PID D030565.Drugs: Topical Corticoesteroids. FDA Web site; 2003. www.fda.gov/ohrms/dockets/ac/03/briefing/3999b1_22_karwoski-memo%2009-26-03.doc

  7. Álvarez AT, Escobar MD, González AIS, Álvarez AY, et al.Glucocorticoid deprivation syndrome. Case presentation.Rev Méd Electr 2019; 41 (1): 180-188.

  8. Virgili JR, García AC. Insuficiencia suprarrenal iatrogénica.SEMERGEN-Medicina de Familia. 2012; 38 (7): 468-471.

  9. Hernández WR. Uso correcto de los esteroides tópicos enatención primaria. Rev Méd Costa Rica y Centroamer 2014;71 (613): 801-806.




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