Ramírez-Alvarado DD, Marlon-Varela D, Chinchilla-Castañeda K

Language: Spanish
References: 16
Page: 139-143
PDF size: 229.18 Kb.

ABSTRACT

Introduction: therapeutic adherence is variable and can be affected for different reasons. Objective: to describe the frequency and factors or barriers related to lack of therapeutic adherence in pediatric patients with epilepsy during the COVID-19 pandemic. Material and methods: cross-sectional study. 101 patients younger than 18 years, with epilepsy and who had appointments scheduled in 2020 and 2021 were included. The information was collected through a review of records, as well as a telephone interview where a validated scale was applied to record data on adherence. The statistical analysis was descriptive. Results: the mean age was 8.2 years; 54.2 were male (54.2%). The highest percentage (75%) had generalized epilepsy and 49.1% received valproic acid. 56.7% presented decompensation of epileptic seizures during the pandemic. 51% had low adherence. The main barrier to non-adherence was not being able to attend the appointment due to COVID-19, followed by financial problems. Conclusions: strategies to reduce contagion during the COVID-19 pandemic influenced the lack of therapeutic adherence in patients with epilepsy.

REFERENCES

1. Gutiérrez-Colina AM, Smith AW, Mara CA, Modi AC. Adherence barriers in pediatric epilepsy: From toddlers to young adults. Epilepsy Behav. 2018; 80: 229-234.

2. Al-Aqeel S, Al-Sabhan J. Strategies for improving adherence to antiepileptic drug treatment in patients with epilepsy. Cochrane Database Syst Rev. 2011; (1): CD008312.

3. Alsous M, Hamdan I, Saleh M, McElnay J, Horne R, Masri A. Predictors of nonadherence in children and adolescents with epilepsy: A multimethod assessment approach. Epilepsy Behav. 2018; 85: 205-211.

4. Ramsey RR, Zhang N, Modi AC. The stability and influence of barriers to medication adherence on seizure outcomes and adherence in children with epilepsy over 2 years. J Pediatr Psychol. 2018; 43(2): 122-132.

5. Suzuki H, Mikuni N, Ohnishi H, Yokoyama R, Enatsu R, Ochi S. Forgetting to take antiseizure medications is associated with focal to bilateral tonic-clonic seizures, as revealed by a cross-sectional study. PloS One. 2020; 15(10): e0240082.

6. Trivisano M, Specchio N, Pietrafusa N, Calabrese C, Ferretti A, Ricci R et al. Impact of COVID-19 pandemic on pediatric patients with epilepsy - The caregiver perspective. Epilepsy Behav. 2020; 113: 107527.

7. Durón R, Medina M, Holden K, Ramírez F, Aguilar R, Zelaya A, et al. Estudio sobre el cumplimiento del tratamiento por los pacientes epilépticos en el Hospital Escuela. Rev Med Hond. 2001; 69(4): 140-146.

8. Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L et al. ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology. Epilepsia. 2017; 58(4): 512-521.

9. Moosa ANV. Antiepileptic drug treatment of epilepsy in children. Continuum (Minneap Minn). 2019; 25(2): 381-407.

10. Ibinda F, Odermatt P, Kariuki SM, Kakooza-Mwesige A, Wagner RG, Owusu-Agyei S, et al. Magnitude and factors associated with nonadherence to antiepileptic drug treatment in Africa: a cross-sectional multisite study. Epilepsia Open. 2017; 2(2): 226-235.

11. Henning O, Johannessen Landmark C, Nakken KO, Lossius MI. Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence. Epilepsia. 2019; 60(5): e58-e62.

12. Yang C, Hao Z, Yu D, Xu Q, Zhang L. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta analysis. Epilepsy Res. 2018; 142: 88-99.

13. DiIorio C, Yeager K, Shafer PO, Letz R, Henry T, Schomer DL et al. The epilepsy medication and treatment complexity index: reliability and validity testing. J Neurosci Nurs. 2003; 35(3): 155-162.

14. Zongo A, Guenette L, Moisan J, Guillaumie L, Lauzier S, Gregoire JP. Revisiting the internal consistency and factorial validity of the 8-item Morisky medication adherence scale. SAGE Open Med. 2016; 4: 2050312116674850.

15. Valencia-Monsalvez F, Mendoza-Parra S, Luengo-Machuca L. Valencia-Monsalvez F, Mendoza-Parra S, Luengo-Machuca L. Evaluación de la escala Morisky de adherencia a la medicación (mmas-8) en adultos mayores de un centro de atención primaria en Chile. Rev Peru Med Exp Salud Publica. 2017; 34(2): 245-249.

16. Banks J, Varley J, Fitzsimons M, Doherty CP. Self-reported antiepilepsy medication adherence and its connection to perception of medication error. Epilepsy Behav. 2020; 104(Pt A): 106896.