Espinoza-Hernández JD

Language: English
References: 5
Page: 74-75
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Text Extraction

The FAME 3 trial (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) found that FFR guided PCI using current generation zotarolimus DES did not meet the criterion set for noninferiority about major adverse cardiac and cerebrovascular events at 1 year compared with CABG. In another publication, the same authors analyzed the quality of life of these patients at 12 months using three variables: quality of life, measured by European Quality of Life–5 Dimensions (EQ-5D), grade of angina by the Canadian Cardiovascular Class (CCS) and work status, this was assessed at baseline, one, six, and 12 months, with patients classified as working (full-time or part-time) or not working (due to retirement, health restriction or other reasons), with a pre-specified subgroup comparison for patients of working age, i.e., ‹65 years old at baseline. Their conclusion was in patients with 3V-CAD, quality of life and angina severity at 12 months are similar after FFR-guided PCI with current generation DES compared with CABG. FFR-guided PCI results in a faster improvement in quality of life than CABG during the first year after revascularization as was working status in those ‹ 65 years-old.

REFERENCES

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2. Fearon WF, Zimmermann FM, Ding VY, et al; FAME 3 Investigators. Quality ofLife After Fractional Flow Reserve-Guided PCI Compared with Coronary BypassSurgery. Circulation. 2022;145(22):1655-1662. doi: 10.1161/CIRCULATIONAHA.122.060049.

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5. Weintraub WS; Grau-Sepulveda MV; Weiss JM; O’Brien SM; Peterson ED, et.al.Comparative Effectiveness of Revascularization Strategies. N Engl J Med 2012;366:1467-76. Weintraub WS, Grau-Sepulveda MV, Weiss JM, et al. Comparativeeffectiveness of revascularization strategies. N Engl J Med. 2012;366(16):1467-76. doi: 10.1056/NEJMoa1110717.