2022, Number 2
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Cir Card Mex 2022; 7 (2)
Cardiac Xenotransplantation
Calderón-Abbo MC
Language: English
References: 9
Page: 23-24
PDF size: 128.89 Kb.
Text Extraction
In an article published by Pietro Bajona et al. in the Annals
of Thoracic Surgery in 2016, in which the distinguished
surgeon, transplant pioneer and xenotransplant
researcher David K.C. Cooper et al., the authors stated:
“when pig hearts could be successfully transplanted into patients
with end-stage heart failure; the problem of the availability
of organs for transplantation will be solved.”
This powerful statement began to gain strength after the
recent news the first days of January 2022 when the media
reported the successful performance of a porcine to human
heart transplant at the University of Maryland Hospital
Center, United States of America, by the respected surgeon
Bartley Griffith and coworkers. The news took the world
by surprise, especially to the medical community. Many of
us who have devoted ourselves for years to the study and
treatment of terminal heart diseases, did not anticipate that
during the last few years the research programs for the development
of transgenic animals would have been resumed.
During the 1990's there was a slowdown in research of
transgenic animals for transplantation purposes since it was
demonstrated that the porcine retrovirus (PERV) was capable
of infecting human cell with the risk of transmission of
swine diseases to immunosuppressed humans and the possibility
of consequent pandemics.
REFERENCES
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Reardon S. First pig-to-human heart transplant: what can scientists learn? Nature.2022;601(7893):305-306. doi: 10.1038/d41586-022-00111-9.
Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenousretrovirus of pigs. Nat Med. 1997;3(3):282-6. doi: 10.1038/nm0397-282.
Rabin RC. In a first, Man receives a Heart from a genetically altered pig. The NewYork Times, Jan 10, 2022. available at: https://www.nytimes.com/2022/01/10/health/heart-transplant-pig-bennett.html. Last accessed: Feb 14, 2022.
Crick SJ, Sheppard MN, Ho SY, Gebstein L, Anderson RH. Anatomy of the pigheart: comparisons with normal human cardiac structure. J Anat. 1998;193 ( Pt 1)(Pt 1):105-119. doi:10.1046/j.1469-7580.1998.19310105.x.
Servick K. Here´s how scientists pulled off the first pig-to human heart transplantdoi: 10.1126/science.ada0089. Available at: https://www.science.org/content/article/here-s-how-scientists-pulled-first-pig-human-heart-transplant. Last accessed:Feb 14, 2022.
Cookson C. Gene editing: pig hearts and the new era of organ transplants. TheFinancial Times. Available at : https://www.ft.com/content/72c888a8-c0e3-4d66-
8446-b554ad523529. Last accessed: Feb 15, 2022.8. Wu G, Pfeiffer S, Schröder C, et al. Coagulation cascade activation triggers earlyfailure of pig hearts expressing human complement regulatory genes. Xenotransplantation.2007;14(1):34-47. doi: 10.1111/j.1399-3089.2006.00362.x.
Frazier OH. Personal Communication. (2022).
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