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Alergia, Asma e Inmunología Pediátricas

Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría
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2023, Number 1-3

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Alerg Asma Inmunol Pediatr 2023; 32 (1-3)

Basic measures aimed at doctors to prevent or detect glucocorticoid-induced osteoporosis

Peralta-Pedrero ML, Cruz-Avelar A
Full text How to cite this article 10.35366/115243

DOI

DOI: 10.35366/115243
URL: https://dx.doi.org/10.35366/115243

Language: Spanish
References: 5
Page: 23-26
PDF size: 135.28 Kb.


Key words:

secondary osteoporosis, glucocorticoids, adverse events.

ABSTRACT

Glucocorticoid-induced osteoporosis is a common, under-reported, and potentially serious adverse event. The general practitioner and specialists outside of rheumatology, such as family doctors, dermatologists, allergists, pulmonologists, gastroenterologists, among others, must prevent or detect this adverse event. When the patient's risk is evaluated before starting treatment with glucocorticoids, it is possible to take early actions that minimize the accelerated bone deterioration at the beginning of therapy. The FRAX tool is useful for calculating the 10-year risk of fragility fractures, but the presence of autoimmune diseases, not just rheumatoid arthritis, must be considered, as they are themselves a risk factor for osteoporosis. Bone mineral density and/or FRAX values are complementary parameters in the health professional's decision making; the dose per day, cumulative dose per year, time and route of administration, type of glucocorticoid, presence of morbidities that by themselves or due to their treatment interfere with bone health, lifestyle, constitutional characteristics of the patient, must also be evaluated personal history of fragility fractures and family history of hip fracture. Twenty-six considerations are presented to prevent or early detect osteoporosis secondary to the use of glucocorticoids.


REFERENCES

  1. Weare-Regales N, Hudey SN, Lockey RF. Practical guidance for prevention and management of glucocorticoid-induced osteoporosis for the allergist/immunologist. J Allergy Clin Immunol Pract. 2021; 9 (5): 1841-1850. doi: 10.1016/j.jaip.2020.12.050.

  2. Lupsa BC, Insogna KL, Micheletti RG, Caplan A. Corticosteroid use in chronic dermatologic disorders and osteoporosis. Int J Womens Dermatol. 2021; 7 (5Part A): 545-551. doi: 10.1016/j.ijwd.2021.07.014.

  3. Pereira RMR, Perez MO, Paula AP, Moreira C, Castro CHM, Zerbini CAF et al. Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis: an update of Brazilian Society of Rheumatology (2020). Arch Osteoporos. 2021; 16 (1): 49. doi: 10.1007/s11657-021-00902-z.

  4. Lee TH, Song YJ, Kim H, Sung YK, Cho SK. Intervention thresholds for treatment in patients with glucocorticoid-induced osteoporosis: systematic review of guidelines. J Bone Metab. 2020; 27 (4): 247-259. doi: 10.11005/jbm.2020.27.4.247.

  5. Egeberg A, Schwarz P, Harslof T, Andersen YMF, Pottegard A, Hallas J et al. Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures. JAMA Dermatol. 2021; 157 (3): 275-282. doi: 10.1001/jamadermatol.2020.4968.




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C?MO CITAR (Vancouver)

Alerg Asma Inmunol Pediatr. 2023;32