medigraphic.com
Órgano Oficial del Hospital Angeles Health System

2024, Number 2

<< Back Next >>

Acta Med 2024; 22 (2)

Left ventricle global longitudinal strain, troponins and other echocardiographic variables as predictors of subclinical myocardial injury in hospitalized patients with COVID-19

Sánchez LF, Salazar HDL, García LA, Domínguez CLG

Language: Spanish
References: 17
Page: 110-115
PDF size: 232.12 Kb.


ABSTRACT

Introduction: subclinical myocardial injury by COVID-19 is frequent. hs-cTnI, global longitudinal strain (GLS), and other echocardiographic variables (EV) are helpful for early detection. Objective: to correlate UT, GLS, and EV with adverse prognosis in hospitalized patients with COVID-19. Material and methods: 36 hospitalized patients with an average age of 57.47 years were studied. Usual echocardiographic measurements of SLG and hs-cTnI were performed. The sample was divided into critical and non-critical patients. Statistical analysis: the comparison was made with the Student's t-test and Fisher's exact test. Results: GLS values and LA dilation were not statistically significant on prognosis; the increase in pulmonary pressure showed significance with p = 0.03; hs-cTnI increase p = 0.05; e' with p = 0.03 and E/e ratio with p = 0.005. Conclusions: prolonged hospital stance and mortality are increased in patients with COVID-19 who present increased pulmonary pressure and elevation of troponins, as well as with markers of left ventricle diastolic dysfunction e' and E/e'. GLS did not show statistical significance.


REFERENCES

  1. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F et al. Association of Cardiac Injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020; 5 (7): 802-810. doi: 10.1001/jamacardio.2020.0950.

  2. Nishiga M, Wang DW, Han Y, Lewis DB, Wu JC. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nat Rev Cardiol. 2020; 17 (9): 543-558. doi: 10.1038/s41569-020-0413-9.

  3. Shi S, Qin M, Cai Y, Liu T, Shen B, Yang F et al. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. 2020; 41 (22): 2070-2079. doi: 10.1093/eurheartj/ehaa408.

  4. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA et al. Fourth universal definition of myocardial infarction (2018). J Am Coll Cardiol. 2018; 72 (18): 2231-2264. doi: 10.1016/j.jacc.2018.08.1038.

  5. Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020; 17 (5): 259-260. doi: 10.1038/s41569-020-0360-5.

  6. Akhmerov A, Marbán E. COVID-19 and the heart. Circ Res. 2020; 126 (10): 1443-1455. doi: 10.1161/CIRCRESAHA.120.317055.

  7. Bhatti H, Cordova Sanchez A, Dhungana R, Carvounis C, Singh A. Left ventricular global longitudinal strain in patients with COVID-19 infection. Cureus. 2022; 14 (4): e23986. doi: 10.7759/cureus.23986.

  8. Sánchez Lezama F, Domínguez Carrillo LG, Rivas León SC, Flores Peña D. Correlación del strain longitudinal global con el grado de disfunción diastólica, factores de riesgo cardiovascular y variables del ecocardiograma 2D. Acta Méd Grupo Ángeles. 2021; 19 (4): 485-490.

  9. Lee WC. Subclinical myocardial dysfunction and reduced left ventricular global longitudinal strain in patients with COVID-19. Int J Cardiovasc Imaging. 2021; 37 (10): 2991-2992. doi: 10.1007/s10554-021-02386-x.

  10. Mahajan S, Kunal S, Shah B, Garg S, Palleda GM, Bansal A et al. Left ventricular global longitudinal strain in COVID-19 recovered patients. Echocardiography. 2021; 38 (10): 1722-1730. doi: 10.1111/echo.15199.

  11. Moreno-Pérez O, Andrés M, León-Ramirez JM, Sánchez-Payá J, Boix V, Gil J et al. The COVID-GRAM tool for patients hospitalized with COVID-19 in Europe. JAMA Intern Med. 2021; 181 (7): 1000-1001. doi: 10.1001/jamainternmed.2021.0491.

  12. COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available in: https://www.covid19treatmentguidelines.nih.gov/

  13. Abou R, van der Bijl P, Bax JJ, Delgado V. Global longitudinal strain: clinical use and prognostic implications in contemporary practice. Heart. 2020; 106 (18): 1438-1444. doi: 10.1136/heartjnl-2019-316215.

  14. Farsalinos KE, Daraban AM, Unlu S, Thomas JD, Badano LP, Voigt JU. Head-to-head comparison of global longitudinal strain measurements among nine different vendors: the EACVI/ASE inter-vendor comparison study. J Am Soc Echocardiogr. 2015; 28 (10): 1171-1181, e2. doi: 10.1016/j.echo.2015.06.011.

  15. Stöbe S, Richter S, Seige M, Stehr S, Laufs U, Hagendorff A. Echocardiographic characteristics of patients with SARS-CoV-2 infection. Clin Res Cardiol. 2020; 109 (12): 1549-1566. doi: 10.1007/s00392-020-01727-5.

  16. García-Cruz E, Manzur-Sandoval D, Rascón-Sabido R, Gopar-Nieto R, Barajas-Campos RL, Jordán-Ríos A et al. Critical care ultrasonography during COVID-19 pandemic: The ORACLE protocol. Echocardiography. 2020; 37 (9): 1353-1361. doi: 10.1111/echo.14837.

  17. Turan T, Ozderya A, Sahin S, Konus AH, Kul S, Akyüz AR et al. Left ventricular global longitudinal strain in low cardiac risk outpatients who recently recovered from coronavirus disease 2019. Int J Cardiovasc Imaging. 2021; 37 (10): 2979-2989. doi: 10.1007/s10554-021-02376-z.




2020     |     www.medigraphic.com