Serralde ZAE, Meléndez MG, Infante SH

Language: Spanish
References: 36
Page: 241-246
PDF size: 121.50 Kb.

ABSTRACT

The evaluation of recommendations for vitamins has been based on requirements to prevent deficiencies and diseases associated with them. Folates have served as a prototype to demonstrate the influence of the genotype on nutrient requirements. According to epidemiological studies, folate deficiency and increases in homocysteine levels increase the risk of developing neural tube defects and cardiovascular diseases. Different alterations in the function of receptors, transporters or enzymes due to polymorphism in the genes that encode them, negatively affect folate metabolism. An example is the case of C677T which has a high prevalence in our country and modifies the response to diet, with increases in folate requirements. In order to provide better recommendations for the entire population, it is necessary to include the impact of genetic variation and to consider the requirements of every individual according to his or her genomic profile.

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