medigraphic.com
Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2023, Number 2

<< Back Next >>

Rev Med UV 2023; 23 (2)

Exposure to endocrine disruptors and its probable relation with overweight and obesity

Méndez BE, Hernández RN, Ramírez SI, Méndez GD

Language: Spanish
References: 50
Page: 19-43
PDF size: 458.38 Kb.


ABSTRACT

Endocrine Disruptors are any chemical substance with the ability to interfere with the normal function of the endocrine system causing unwanted effects on the health of an intact organism and its progeny. Exposure to these compounds has been related to various diseases such as cancer, infertility, behavioral effects and in recent years with the accelerated increase in the rates of overweight and obesity, since according to the World Health Organization (WHO) these diseases have almost tripled from 1975 to 2016, this type of Endocrine Disruptors is known as obesogens, chemical compounds with the ability to interfere in the processes that regulate lipid metabolism, as well as in the control mechanisms in the differentiation and proliferation of adipocytes.
The aim of this bibliographical review is to provide updated information on the relationship between chronic exposure to Endocrine Disruptors and the increase in recent years in the rates of overweight and obesity. The search for information was done in databases such as PUBMED, and official websites such as WHO, EFSA, FDA y EPA, among others.
Finally, the evidence that exists to date suggests the possibility that there is a probable relationship between exposure to Endocrine Disruptors and the presence of overweight and obesity. Currently only the European Union through the EFSA has very strict legislation for the use of these chemical compounds; unfortunately in our country there is no law that regulates them, causing the indiscriminate use of these in part due to ignorance of its effects, which is why it is of great importance to take measures to reduce this exposure and its effects, representing a huge challenge.


REFERENCES

  1. Al-Hiyasat, A. S., Darmani, H., & Elbetieha, A. M. (2002). Effects of bisphenolA on adult male mouse fertility. European Journal of OralSciences, 110(2), 163–167. https://doi.org/10.1034/j.1600-0722.2002.11201.x

  2. Angle, B. M., Do, R. P., Ponzi, D., Stahlhut, R. W., Drury, B. E., Nagel, S.C., Welshons, W. V., Besch-Williford, C. L., Palanza, P., Parmigiani,S., vom Saal, F. S., & Taylor, J. A. (2013). Metabolic Disruption inMale Mice due to Fetal Exposure to Low but not High Doses ofBisphenol A (BPA): Evidence for Effects on Body Weight, FoodIntake, Adipocytes, Leptin, Adiponectin, Insulin and GlucoseRegulation. Reproductive Toxicology, 42, 256–268. https://doi.org/10.1016/j.reprotox.2013.07.017

  3. Antizar-Ladislao, B. (2008). Environmental Levels, Toxicity and HumanExposure to Tributyltin (TBT)-Contaminated Marine Environment.A Review. Environment International, 34(2), 292–308.https://doi.org/10.1016/j.envint.2007.09.005

  4. Baillie-Hamilton, P. F. (2002). Chemical Toxins: A Hypothesis to Explainthe Global Obesity Epidemic. The Journal of Alternativeand Complementary Medicine, 8(2), 185–192. https://doi.org/10.1089/107555302317371479

  5. Barbosa, C. M. D. L., Ferrão, F. M., & Graceli, J. B. (2018). Organotin CompoundsToxicity: Focus on Kidney. Frontiers in Endocrinology, 9,256. https://doi.org/10.3389/fendo.2018.00256

  6. Bisphenol applications. (2021, 19 marzo). Bisphenol. http://bisphenol-a-europe.org/applications/

  7. Cao, J., Echelberger, R., Liu, M., Sluzas, E., McCaffrey, K., Buckley, B.,& Patisaul, H. B. (2015). Soy But Not Bisphenol A (BPA) or thePhytoestrogen Genistin Alters Developmental Weight Gain andFood Intake in Pregnant Rats and their Offspring. ReproductiveToxicology, 58, 282–294. https://doi.org/10.1016/j.reprotox.2015.07.077

  8. Carfi’, M., Croera, C., Ferrario, D., Campi, V., Bowe, G., Pieters, R., & Gribaldo,L. (2008). TBTC Induces Adipocyte Differentiation in HumanBone Marrow Long Term Culture. Toxicology, 249(1), 11–18. https://doi.org/10.1016/j.tox.2008.03.025.

  9. Chamorro-García, R., Sahu, M., Abbey, R. J., Laude, J., Pham, N., & Blumberg,B. (2013). Transgenerational Inheritance of Increased FatDepot Size, Stem Cell Reprogramming, and Hepatic SteatosisElicited by Prenatal Exposure to the Obesogen Tributyltin inMice. Environmental Health Perspectives, 121(3), 359–366. https://doi.org/10.1289/ehp.1205701

  10. Chien, L. C., Hung, T. C., Choang, K. Y., Yeh, C. Y., Meng, P. J., Shieh, M. J., &Han, B. C. (2002). Daily Intake of TBT, Cu, Zn, Cd and As For Fishermenin Taiwan. Science of The Total Environment, 285(1–3),177–185. https://doi.org/10.1016/s0048-9697(01)00916-0

  11. Danciu, C., Soica, C., Csanyi, E., Ambrus, R., Feflea, S., Peev, C., & Dehelean,C. (2012). Changes in the Anti-inflammatory Activity of SoyIsoflavonoid Genistein Versus Genistein Incorporated in TwoTypes of Cyclodextrin Derivatives. Chemistry Central Journal,6(1), 1–10. https://doi.org/10.1186/1752-153x-6-58

  12. Darbre, P. D. (2017). Endocrine Disruptors and Obesity. Current ObesityReports, 6(1), 18–27. https://doi.org/10.1007/s13679-017-0240-4

  13. Endocrine Disruptors. (s. f.). National Institute of Environmental Health Sciences.https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm

  14. European Comission. https://ec.europa.eu/commission/presscorner/detail/es/IP_16_2152

  15. Estructura química del tributil estaño. (s. f.). MERCK MILLIPORE. http://www.merckmillipore.com/MX/es/product/Tributyltin-hydride,MDA_CHEM-814109?ReferrerURL=https%3A%2F%2Fwww.google.com.mx-%2F

  16. Estructura química del trifenil estaño, FISHER SCIENTIFIC, recuperado de: https://www.fishersci.es/shop/products/triphenyltin-chloride-95-thermo-scientific-1/11369085

  17. García, J. A., Gallego, C., & Font, G. (2012). Toxicidad de Bisfenol A: Revisión. RevistaToxicología, 32(1), 144–160.

  18. Giusti, R. M. (1995). Diethylstilbestrol Revisited: A Review of the Long-TermHealth Effects. Annals of Internal Medicine, 122(10), 778–788. https://doi.org/10.7326/0003-4819-122-10-199505150-00008

  19. Hao, M., Ding, L., Xuan, L., Wang, T., Li, M., Zhao, Z., Lu, J., Xu, Y., Chen, Y., Wang, W., Bi, Y., Xu, M., & Ning, G. (2017). Urinary Bisphenol A Concentration andthe Risk of Central Obesity in Chinese Adults: A Prospective Study. Journalof Diabetes, 10(6), 442–448. https://doi.org/10.1111/1753-0407.12531

  20. Hatch, E. E., Troisi, R., Palmer, J. R., Wise, L. A., Titus, L., Strohsnitter, W. C., Ricker,W., Hyer, M., & Hoover, R. N. (2015). Prenatal Diethylstilbestrol Exposureand Risk of Obesity in Adult Women. Journal of Developmental Originsof Health and Disease, 6(3), 201–207. https://doi.org/10.1017/s2040174415000033

  21. Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A.,Nadal, A., Palanza, P., Panzica, G., Sargis, R., Vandenberg, L. N., & vom Saal, F.(2017). Metabolism Disrupting Chemicals and Metabolic Disorders. ReproductiveToxicology, 68, 3–33. https://doi.org/10.1016/j.reprotox.2016.10.001

  22. Herbst, A. L., Ulfelder, H., & Poskanzer, D. C. (1971). Adenocarcinoma of the Vagina.New England Journal of Medicine, 284(16), 878–881. https://doi.org/10.1056/nejm197104222841604

  23. Ho, S. M., Tang, W. Y., Belmonte De Frausto, J., & Prins, G. S. (2006). DevelopmentalExposure to Estradiol and Bisphenol A Increases Susceptibility toProstate Carcinogenesis and Epigenetically Regulates PhosphodiesteraseType 4 Variant 4. Cancer Research, 66(11), 5624–5632. https://doi.org/10.1158/0008-5472.can-06-0516

  24. Hong, S. H., Sung, Y. A., Hong, Y. S., Ha, E., Jeong, K., Chung, H., & Lee, H. (2016).Urinary bisphenol A is Associated with Insulin Resistance and Obesity inReproductive-aged Women. Clinical Endocrinology, 86(4), 506–512. https://doi.org/10.1111/cen.13270

  25. Jensen, E. T., & Longnecker, M. P. (2014). Pharmacologic Sex Hormones in Pregnancyin Relation to Offspring Obesity. Obesity, 22(11), 2406–2412. https://doi.org/10.1002/oby.20778

  26. Kanayama, T., Kobayashi, N., Mamiya, S., Nakanishi, T., & Nishikawa, J. I. (2004).Organotin Compounds Promote Adipocyte Differentiation as Agonistsof the Peroxisome Proliferator-Activated Receptor γ/Retinoid X ReceptorPathway. Molecular Pharmacology, 67(3), 766–774. https://doi.org/10.1124/mol.104.008409

  27. Lanthier, N., & Leclercq, I. A. (2014). Adipose Tissues as Endocrine Target Organs.Best Practice & Research Clinical Gastroenterology, 28(4), 545–558.https://doi.org/10.1016/j.bpg.2014.07.002

  28. Laronda, M. M., Unno, K., Butler, L. M., & Kurita, T. (2012). The Developmentof Cervical and Vaginal Adenosis as a Result of Diethylstilbestrol Exposurein Utero. Differentiation, 84(3), 252–260. https://doi.org/10.1016/j.diff.2012.05.004

  29. Lind, P. M., Zethelius, B., & Lind, L. (2012). Circulating Levels of Phthalate Metabolitesare Associated With Prevalent Diabetes in the Elderly. DiabetesCare, 35(7), 1519–1524. https://doi.org/10.2337/dc11-2396

  30. Matthiessen, P., & Gibbs, P. E. (1998). Critical Appraisal of the Evidence forTributyltin-mediated Endocrine Disruption in Mollusks. EnvironmentalToxicology and Chemistry, 17(1), 37–43. https://doi.org/10.1002/etc.5620170106

  31. Menale, C., Piccolo, M. T., Cirillo, G., Calogero, R. A., Papparella, A., Mita, L., Giudice,E. M. D., Diano, N., Crispi, S., & Mita, D. G. (2015). Bisphenol A Effectson Gene Expression in Adipocytes from Children: Association withMetabolic Disorders. Journal of Molecular Endocrinology, 54(3), 289–303.https://doi.org/10.1530/jme-14-0282

  32. Michałowicz, J. (2014). Bisphenol A – Sources, Toxicity and Biotransformation.Environmental Toxicology and Pharmacology, 37(2), 738–758. https://doi.org/10.1016/j.etap.2014.02.003

  33. Mnif, W., Hassine, A. I. H., Bouaziz, A., Bartegi, A., Thomas, O., & Roig, B. (2011).Effect of Endocrine Disruptor Pesticides: A Review. International Journalof Environmental Research and Public Health, 8(6), 2265–2303. https://doi.org/10.3390/ijerph8062265

  34. Mollo Tangara, J. C., & Montaño Cabrera, L. A. (2013). Disruptores endocrinosen el plástico (Bisfenol A y Ftalatos). Scientifica, 11(1), 19–22.

  35. Navarro, R., & Reiecke, H. (2013). Plastificantes de todo tipo. Revista de PlásticosModernos: Ciencia y Tecnología de Polímeros, 103(664), 14–19.

  36. Nielsen, J. B., & Strand, J. (2002). Butyltin Compounds in Human Liver. EnvironmentalResearch, 88(2), 129–133. https://doi.org/10.1006/enrs.2001.4321

  37. Obesidad y sobrepeso. (2021, 9 junio). Organización Mundial de la Salud. https://www.who.int/es/news-room/fact-sheets/detail/obesity-and-overweight

  38. Oehlmann, J., Bauer, B., Minchin, D., Schulte-Oehlmann, U., Fioroni, P., & Markert,B. (1998). Imposex in Nucella Lapillus and Intersex in Littorina Littorea:Interspecific Comparison of Two TBT-induced Effects and theirGeographical Uniformity. Hydrobiologia, 378(1/3), 199–213. https://doi.org/10.1023/a:1003218411850

  39. Oktar, S., Sungur, S., Okur, R., Yilmaz, N., Ustun, I., & Gokce, C. (2017). The RelationshipBetween Phthalates and Obesity: Serum and Urine Concentrationsof Phthalates. Minerva Endocrinology, 42(1), 46–51. https://doi.org/10.23736/s0391-1977.16.02295-1

  40. Ørgaard, A., & Jensen, L. (2008). The Effects of Soy Isoflavones on Obesity.Experimental Biology and Medicine, 233(9), 1066–1080. https://doi.org/10.3181/0712-mr-347

  41. Penza, M., Montani, C., Romani, A., Vignolini, P., Pampaloni, B., Tanini, A.,Brandi, M. L., Alonso-Magdalena, P., Nadal, A., Ottobrini, L., Parolini, O.,Bignotti, E., Calza, S., Maggi, A., Grigolato, P. G., & di Lorenzo, D. (2006).Genistein Affects Adipose Tissue Deposition in a Dose-Dependent andGender-Specific Manner. Endocrinology, 147(12), 5740–5751. https://doi.org/10.1210/en.2006-0365

  42. Plásticos – Situación en 2020. (2020). Plastics Europe. https://plasticseurope.org/es/wp-content/uploads/sites/4/2021/11/ES_Plastics_the_facts-WEB-2020_May21_final_updatedJuly2021.pdf

  43. Quagliariello, V., Rossetti, S., Cavaliere, C., di Palo, R., Lamantia, E., Castaldo,L., Nocerino, F., Ametrano, G., Cappuccio, F., Malzone, G., Montanari, M.,Vanacore, D., Romano, F. J., Piscitelli, R., Iovane, G., Pepe, M. F., Berretta,M., D’Aniello, C., Perdonà, S., Muto, P., Botti, G., Ciliberto, G., Veneziani, B.M., De Falco, F., Maiolino, P., Caraglia, M., Montella, M., Iaffaioli, R. V., Facchini,G. (2017). Correction: Metabolic Syndrome, Endocrine Disruptorsand Prostate Cancer Associations: Biochemical and PathophysiologicalEvidences. Oncotarget, 8(37), 62816. https://doi.org/10.18632/oncotarget.20631

  44. Rantakokko, P., Main, K. M., Wohlfart-Veje, C., Kiviranta, H., Airaksinen, R., Vartiainen,T., Skakkebæk, N. E., Toppari, J., & Virtanen, H. E. (2014). Associationof Placenta Organotin Concentrations with Growth and PonderalIndex in 110 Newborn Boys From Finland During the First 18 Monthsof Life: a Cohort Study. Environmental Health, 13(1), 45. https://doi.org/10.1186/1476-069x-13-45

  45. Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness,C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007). In VivoEffects of Bisphenol A in Laboratory Rodent Studies. Reproductive Toxicology,24(2), 199–224. https://doi.org/10.1016/j.reprotox.2007.06.004

  46. Rochester, J. R. (2013). Bisphenol A and Human Health: A Review of the Literature.Reproductive Toxicology, 42, 132–155. https://doi.org/10.1016/j.reprotox.2013.08.008

  47. Troisi, R., Titus, L., Hatch, E. E., Palmer, J. R., Huo, D., Strohsnitter, W. C., Adam, E.,Ricker, W., Hyer, M., & Hoover, R. N. (2017). A Prospective Cohort Study ofPrenatal Diethylstilbestrol Exposure and Cardiovascular Disease Risk. TheJournal of Clinical Endocrinology & Metabolism, 103(1), 206–212. https://doi.org/10.1210/jc.2017-01940

  48. Vandenberg, L. N. (2014). Low-dose Effects of Hormones and Endocrine Disruptors.Vitamins & Hormones, 94, 129–165. https://doi.org/10.1016/b978-0-12-800095-3.00005-5

  49. Welshons, W. V., Nagel, S. C., & vom Saal, F. S. (2006). Large Effects from SmallExposures. III. Endocrine Mechanisms Mediating Effects of Bisphenol Aat Levels of Human Exposure. Endocrinology, 147(6), 56–69. https://doi.org/10.1210/en.2005-1159

  50. Zanella, I., Marrazzo, E., Biasiotto, G., Penza, M., Romani, A., Vignolini, P., Caimi, L.,& di Lorenzo, D. (2014). Soy and the Soy Isoflavone Genistein Promote AdiposeTissue Development in Male Mice on a Low-fat Diet. European Journalof Nutrition, 54(7), 1095–1107. https://doi.org/10.1007/s00394-014-0786-9




2020     |     www.medigraphic.com