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2022, Number 2

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Rev Cubana Farm 2022; 55 (2)

Inhibition of intestinal transit in albino mice by ethanolic extract of Senecio nutans Schultz-Bip leaves

Anaya GRB, Falconí OV, Castilla TN, Cóndor AR, Paredes EC, Cundia AO

Language: Spanish
References: 27
Page: 1-16
PDF size: 642.83 Kb.


ABSTRACT

Introduction: In Peru, as in other developing countries, gastrointestinal disorders such as diarrhea and abdominal cramps are very common. The population usually uses medicinal plants as a solution because of their easy access and availability, but many of them lack scientific evidence to support their beneficial effects on health.
Objective: Evaluate the inhibitory effect of intestinal transit of ethanolic extract of Senecio nutans Schultz-Bip leaves in albino mice.
Methods: Phytochemical screening was performed as a preliminary test. The inhibitory effect was based on the in vivo model of intestinal transit, with activated charcoal as a marker of intestinal motility, and as an inducer of diarrhea it was used castor oil. Four groups of five male mice (Mus musculus) BALB/c were randomly formed. The first group without any treatment (control); the second with the standard loperamide 1 mg/kg; the other groups, plant extract at 100 mg/kg and 200 mg/kg.
Results: The phytochemical analysis showed a greater presence of flavonoids. Ethanolic extract from S. nutans Schultz-Bip leaves slowed the intestinal transit of activated charcoal in a dose-dependent manner of 100 mg/kg (33.58%) and 200 mg/kg (24.34%); the second dose was similar to standard loperamide which was 15.22% (p< 0.05).
Conclusions: It was demonstrated that the ethanolic extract of S. nutansSchultz-Bip delayed the intestinal transit, with a dependent dose by inhibition of intestinal motility in mice.


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