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ISSN 1561-3046 (Electronic)

2022, Number 2

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Rev Cub Med Mil 2022; 51 (2)

Effect of autologous platelet-rich plasma treatment on patients with thin endometrium

Nguyen TT, Hoang VA, Trinh TS, Do NL, Doan TH, Quan VT, Khoa TB, Trieu TS

Language: English
References: 28
Page:
PDF size: 234.01 Kb.


ABSTRACT

Introduction: The success of frozen embryo transfer cycles depends on a delicate interaction between embryo quality and endometrium. Low pregnancy rates are associated with a thin endometrium.
Objective: To evaluate the effect of autologous platelet-rich plasma treatment on patients with thin endometrium.
Methods: In 34 patients with thin endometrium (< 7 mm), canceled in the previous frozen embryo transfer cycles, autologous platelet-rich plasma was prepared, from autologous peripheral vein blood; intrauterine infusion was given during hormone replacement therapy in frozen embryo transfer cycles. Frozen embryo transfer was performed when the endometrium thickness reached ≥ 7mm.
Results: Six patients canceled the embryo transfer cycle due to endometrium thickness did not reach 7 mm; 28 patients got endometrial thickness ≥ 7 mm and performed frozen embryo transfer. The endometrial thickness was 7.5 ± 0.8 mm, which was significantly thicker than in the previous cycles (5.6 ± 0.79 mm) with p< 0.002, the implantation rate was 23.07 %, and the clinical pregnancy rate was 12/28 (42.8 %).
Conclusion: Autologous platelet-rich plasma improves the endometrial thickness and the pregnancy rate outcomes in women with thin endometrium.


REFERENCES

  1. Diedrich K, Fauser BCJM, Devroey P, Griesinger G, Group obotEARW. The role of the endometrium and embryo in human implantation. Human Reproduction Update. 2007; 13(4): 365-77. DOI: 10.1093/humupd/dmm011

  2. Mouhayar Y, Sharara FI. Modern management of thin lining. Middle East Fertility Society Journal. 2017;22(1):1-12. DOI: 10.1016/j.mefs.2016.09.001

  3. Patel AN, Park E, Kuzman M, Benetti F, Silva FJ, Allickson JG. Multipotent menstrual blood stromal stem cells: isolation, characterization, and differentiation. Cell transplantation. 2008; 17(3): 303-11. DOI: 10.3727/096368908784153922

  4. Richter KS, Bugge KR, Bromer JG, Levy MJ. Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos. Fertility and sterility. 2007; 87(1): 53-9. DOI: 10.1016/j.fertnstert.2006.05.064

  5. Kasius A, Smit JG, Torrance HL, Eijkemans MJ, Mol BW, Opmeer BC, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis. Hum Reprod Update. 2014; 20(4): 530-41. DOI: 10.1093/humupd/dmu011

  6. Check JH, Dietterich C, Check ML, Katz Y. Successful delivery despite conception with a maximal endometrial thickness of 4 mm. Clin Exp Obstet Gynecol. 2003; 30(2-3): 93-4. [access: 11/04/2021]. Available in: https://www.imrpress.com/journal/CEOG/30/2-3/pii/20030216.

  7. Dix E, Check JH. Successful pregnancies following embryo transfer despite very thin late proliferative endometrium. Clin Exp Obstet Gynecol. 2010; 37(1): 15-6. [access: 09/05/2021]. Available in: https://www.imrpress.com/journal/CEOG/37/1/pii/1630629613826-507173421/pdf7.

  8. Kumbak B, Erden HF, Tosun S, Akbas H, Ulug U, Bahceci M. Outcome of assisted reproduction treatment in patients with endometrial thickness less than 7 mm. Reprod Biomed Online. 2009; 18(1): 79-84. DOI: 10.1016/s1472-6483(10)60428-2

  9. El-Toukhy T, Coomarasamy A, Khairy M, Sunkara K, Seed P, Khalaf Y, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertility and sterility. 2008; 89(4): 832-9. DOI: 10.1016/j.fertnstert.2007.04.031

  10. Chen MJ, Yang JH, Peng FH, Chen SU, Ho HN, Yang YS. Extended estrogen administration for women with thin endometrium in frozen-thawed in-vitro fertilization programs. Journal of Assisted Reproduction and Genetics. 2006; 23(7-8): 337-42. DOI: 10.1007/s10815-006-9053-1

  11. Khairy M, Banerjee K, El-Toukhy T, Coomarasamy A, Khalaf Y. Aspirin in women undergoing in vitro fertilization treatment: a systematic review and meta-analysis. Fertility and sterility. 2007; 88(4): 822-31. DOI: 10.1016/j.fertnstert.2006.12.080

  12. Gutarra-Vilchez RB, Bonfill Cosp X, Glujovsky D, Viteri-Garcia A, Runzer-Colmenares FM, Martinez-Zapata MJ. Vasodilators for women undergoing fertility treatment. Cochrane Database Syst Rev. 2018; 10: CD010001. DOI: 10.1002/14651858.CD010001.pub3

  13. Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertility and sterility. 2010; 93(6):1851-8. DOI: 10.1016/j.fertnstert.2008.12.062

  14. Miralaei S, Ashrafi M, Arabipoor A, Zolfaghari Z, Taghvaei S. The incidence rate of unresponsive thin endometrium in frozen embryo transfer cycles: A case-series of therapy with granulocyte colony stimulating factor. Int J Reprod Biomed. 2019; 17(12): 923-8. DOI: 10.18502/ijrm.v17i12.5797

  15. Bodombossou-Djobo MM, Zheng C, Chen S, Yang D. Neuromuscular electrical stimulation and biofeedback therapy may improve endometrial growth for patients with thin endometrium during frozen-thawed embryo transfer: a preliminary report. Reprod Biol Endocrinol. 2011; 9:122. DOI: 10.1186/1477-7827-9-122

  16. Azizi R, Aghebati-Maleki L, Nouri M, Marofi F, Negargar S, Yousefi M. Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy. Biomed Pharmacother. 2018; 102: 333-43. DOI: 10.1016/j.biopha.2018.03.091

  17. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature. The Journal of Bone and Joint Surgery. 2009; 91(8): 987-96. DOI: 10.1302/0301-620x.91b8.22546

  18. Malahias MA, Chytas D, Babis GC, Nikolaou VS. Platelet-rich plasma guided injections: clinical application in peripheral neuropathies. Front Surg. 2014; 1:41. DOI: 10.3389/fsurg.2014.00041

  19. Gato-Calvo L, Magalhaes J, Ruiz-Romero C, Blanco FJ, Burguera EF. Platelet-rich plasma in osteoarthritis treatment: review of current evidence. Ther Adv Chronic Dis. 2019; 10: 2040622319825567. DOI: 10.1177/2040622319825567

  20. Samadi P, Sheykhhasan M, Khoshinani HM. The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review. Aesthetic Plast Surg. 2019; 43(3): 803-14. DOI: 10.1007/s00266-018-1293-9

  21. Yuan T, Guo SC, Han P, Zhang CQ, Zeng BF. Applications of leukocyte- and platelet-rich plasma (L-PRP) in trauma surgery. Curr Pharm Biotechnol. 2012; 13(7): 1173-84. DOI: 10.2174/138920112800624445

  22. Alio JL, Arnalich-Montiel F, Rodriguez AE. The role of »,» ®,® §,§ ­,­ ¹,¹ ²,² ³,³ ß,ß Þ,Þ þ,þ ×,× Ú,Ú ú,ú Û,Û û,û Ù,Ù ù,ù ¨,¨ Ü,Ü ü,ü Ý,Ý ý,ý ¥,¥ ÿ,ÿ ¶,¶ eye platelet rich plasma »,» ®,® §,§ ­,­ ¹,¹ ²,² ³,³ ß,ß Þ,Þ þ,þ ×,× Ú,Ú ú,ú Û,Û û,û Ù,Ù ù,ù ¨,¨ Ü,Ü ü,ü Ý,Ý ý,ý ¥,¥ ÿ,ÿ ¶,¶ (E-PRP) for wound healing in ophthalmology. Curr Pharm Biotechnol. 2012; 13(7): 1257-65. DOI: 10.2174/138920112800624355

  23. Chicharro-Alcantara D, Rubio-Zaragoza M, Damia-Gimenez E, Carrillo-Poveda JM, Cuervo-Serrato B, Pelaez-Gorrea P, et al. Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management. J Funct Biomater. 2018; 9(1): [aprox. 20 p.]. DOI: 10.3390/jfb9010010

  24. Mahajan N, Sharma S. The endometrium in assisted reproductive technology: How thin is thin? J Hum Reprod Sci. 2016; 9(1): 3-8. DOI: 10.4103/0974-1208.178632

  25. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod. 2017; 21(1): 54-6. DOI: 10.5935/1518-0557.20170013

  26. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwan J Obstet Gynecol. 2018; 57(6): 810-3. DOI: 10.1016/j.tjog.2018.10.007

  27. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015; 8(1): 1286-90. [access: 07/05/2021]. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358582/pdf/ijcem0008-1286.pdf27.

  28. Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study. Front Endocrinol (Lausanne). 2019; 10: 61. DOI: 10.3389/fendo.2019.00061




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