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TIP Revista Especializada en Ciencias Químico-Biológicas

2023, Number 1

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TIP Rev Esp Cienc Quim Biol 2023; 26 (1)

Biological activity of proteins from legumes of the Vigna’s genus: A brief review

Mancera-Castro P, González-Cruz L, Bernardino-Nicanor A

Language: Spanish
References: 67
Page: 1-13
PDF size: 370.53 Kb.


ABSTRACT

Plant species of the genus Vigna belong to the group of legumes, they have a high protein content, including albumins and globulins, being the main function as storage proteins; however, they perform defense functions against fungi, insects, and microorganisms, such as the case of lectins, protease inhibitors, α-amylase inhibitors, defensins, lipid transfer proteins (nsLTPs), thionins, cyclotides, among others. Currently, all these proteins, as well as the peptides obtained from their hydrolysis, are considered relevant due to the biological activity they have demonstrated, including anticancer, antihypertensive, antidiabetic, antioxidant, antimicrobial, antifungal, antiviral, and insecticidal properties. These diverse biological activities underscore the potential of Vigna species as valuable resources for developing functional foods and pharmaceutical and agricultural products.


REFERENCES

  1. Abd-allah, H. H., Mahdy, A. M. M., Gad, M. F., Hassan, E.O., Embaby, S. M. & Yaseen, A. (2018). Legume seeddeterioration caused by some mould fungi affecting seedquality. Middle East Journal of Applied Sciences, 8(2),325-336.

  2. Abdel-Shafi, S., Al-Mohammadi, A. R., Osman, A., Enan, G.,Abdel-Hameid, S. & Sitohy, M. (2019). Characterizationand antibacterial activity of 7S and 11S globulins isolatedfrom cowpea seed protein. Molecules, 24(6), 1-15. DOI:10.3390/molecules24061082

  3. Aluko, R. E. (2015). Antihypertensive peptides from foodproteins. Annual Review of Food Science and Technology,6, 235-262. DOI: 10.1146/annurev-food-022814-015520

  4. Ammerman, N. C., Beier-Sexton, M. & Azad, A. F. (2008).Growth and maintenance of Vero cell lines. CurrentProtocols in Microbiology, 11(1), A.44.1-A.4E.7. DOI:10.1002/9780471729259.mca04es11

  5. Apak, R., Özyürek, M., Güçlü, K. & Çapanoʇlu, E.(2016). Antioxidant activity/capacity measurement. 1.Classification, physicochemical principles, mechanisms,and electron transfer (ET)-based assays. Journal ofAgricultural and Food Chemistry, 64(5), 997-1027. DOI:10.1021/acs.jafc.5b04739

  6. Arise, R. O., Acho, M. A., Yekeen, A. A., Omokanye, I. A.,Sunday-Nwaso, E. O, Akiode, O. S. & Malomo, S. O.(2019). Kinetics of angiotensin-1 converting enzymeinhibition and antioxidative properties of Azadirachtaindica seed protein hydrolysates. Heliyon, 5(5), e01747.DOI: 10.1016/j.heliyon.2019.e01747

  7. Badarinath, A. V., Rao, K. M., Chetty, C. M. S., Ramkanth, S.,Rajan, T. V. S. & Gnanaprakash, K. (2010). A review onIn-vitro antioxidant methods: comparisions, correlationsand considerations. International Journal of PharmTechResearch, 2(2), 1276-1285.

  8. Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S. & Kalayci,O. (2012). Oxidative stress and antioxidant defense. WorldAllergy Organization Journal, 5, 9-19. DOI: 10.1097/WOX.0b013e3182439613

  9. Boukar, O., Bhattacharjee, R., Fatokun, C., Kumar, P. L. &Gueye, B. (2013). Cowpea. En M. Singh, I. S. Bisht &H. Upadhyaya (Eds.), Genetic and Genomic Resourcesof Grain Legume Improvement (pp. 137-156). New York:Elsevier Inc., USA.

  10. Carlini, C. R. & Grossi-de-Sá, M. F. (2002). Plant toxic proteinswith insecticidal properties. A review on their potentialitiesas bioinsecticides. Toxicon, 40(11), 1515-1539. DOI:10.1016/S0041-0101(02)00240-4

  11. Castañeda-Pérez, E., Jiménez-Morales, K., Quintal-Novelo, C.,Moo-Puc, R., Chel-Guerrero, L. & Betancur-Ancona, D.(2019). Enzymatic protein hydrolysates and ultrafilteredpeptide fractions from Cowpea Vigna unguiculata L beanwith in vitro antidiabetic potential. Journal of the IranianChemical Society, 16(8), 1773-1781. DOI: 10.1007/s13738-019-01651-0

  12. Chen, Z., Wang, J., Liu, W. & Chen, H. (2016). Physicochemicalcharacterization, antioxidant and anticancer activitiesof proteins from four legume species. Journal of FoodScience and Technology, 54(4), 964-972. DOI: 10.1007/s13197-016-2390-x

  13. Cheung, A., Wong, J. & Ng, T. (2009). Trypsin-Chymotrypsininhibitorsfrom Vigna mungo seeds. Protein& PeptideLetters,16(3), 277-284. DOI: 10.2174/092986609787601714

  14. Consolim-Colombo, F. M. & Bortolotto, L. A. (2018).Endothelium and arterial hypertension. En P. L. Da Luz,P. Libby, A. C. P. Chagas & F. R. M. Laurindo (Eds.),Endothelium and Cardiovascular Diseases: VascularBiology and Clinical Syndromes (pp. 429-437). ElsevierInc.

  15. Cú-Cañetas, T., Ancona, D. B., Tintoré, S. G., Peraza, M. S.& Guerrero, L. C. (2015). Estudios de inhibición in vitrode la enzima convertidora de angiotensina-I, efectoshipotensor y antihipertensivo de fracciones peptídicas deV. unguiculata. Nutrición Hospitalaria, 32(5), 2117-2125.DOI: 10.3305/nh.2015.32.5.9624

  16. dos Santos, I. S., Carvalho, A. O., de Souza-Filho, G. A., dosNascimento, V. V., Machado, O. L. T. & Gomes, V. M.(2010). Purification of a defensin isolated from Vignaunguiculata seeds, its functional expression in Escherichiacoli, and assessment of its insect α-amylase inhibitoryactivity. Protein Expression and Purification, 71(1), 8-15.DOI: 10.1016/j.pep.2009.11.008

  17. Durak, A., Baraniak, B., Jakubczyk, A. & Swieca, M. (2013).Biologically active peptides obtained by enzymatichydrolysis of Adzyki bean seeds. Food Chemistry, 141,2177-2183. DOI: 10.1016/j.foodchem.2013.05.012

  18. El Safadi, Y., Vivet-Boudou, V. & Marquet, R. (2007). HIV-1reverse transcriptase inhibitors. Applied Microbiologyand Biotechnology, 75, 723-737. DOI: 10.1007/s00253-007-0919-7

  19. Franco, O. L., Murad, A. M., Leite, J. R., Mendes, P. A. M.,Prates, M. V. & Bloch, C. (2006). Identification of a cowpeaγ-thionin with bactericidal activity. FEBS Journal, 273(15),3489-3497. DOI: 10.1111/j.1742-4658.2006.05349.x

  20. Friso, S., Carvajar, C. A., Pizzolo, F., Fardella, C. E. &Olivieri, O. (2017). Epigenetics and Arterial Hypertension:Evidences and Perspectives. En J. Laurence & M. VanBeusekom (Eds.), Translating Epigenetics to the Clinic(pp. 159-184). Elsevier Inc.

  21. GLOBOCAN, Global Cancer Observatory (2020). Estimatednumber of new cases in 2020, worldwide, both sexes, allages in Cancer today. Recuperado de https://www.uicc.org/news/globocan-2020-new-global-cancer-data

  22. González-Montoya, M., Cano-Sampedro, E. & Mora-Escobedo,R. (2017). Bioactive peptides from legumes as anticancertherapeutic agents. International Journal of Cancer andClinical Research, 4(081), 1-10. DOI: 10.23937/2378-3419/1410081

  23. Gopar-Nieto, R., Ezquerra-Osorio, A., Chávez-Gómez, N. L.,Manzur-Sandoval, D. & Raymundo-Martínez, G. I. (2021).¿Cómo tratar la hipertensión arterial sistémica? Estrategiasde tratamiento actuales. Archivos de Cardiología de México,91(4), 493-499. DOI: 10.24875/acm.200003011

  24. Gulcin, I. (2020). Antioxidants and antioxidant methods: anupdated overview. Archives of Toxicology, 94, 651-715.DOI: 10.1007/s00204-020-02689-3

  25. Gupta, N., Srivastava, N. & Bhagyawant, S. S. (2018). Vicilin-Amajor storage protein of mungbean exhibits antioxidativepotential, antiproliferative effects and ACE inhibitoryactivity. PLoS ONE, 13(2), 1-17. DOI: 10.1371/journal.pone.0191265

  26. Harouna, D. V., Venkataramana, P. B., Ndakidemi, P. A. &Matemu, A. O. (2018). Under-exploited wild Vigna speciespotentials in human and animal nutrition: A review. GlobalFood Security, 18, 1-11. DOI: 10.1016/j.gfs.2018.06.002

  27. Herniter, I. A., Lo, R., Muñoz-Amatriaín, M., Lo, S., Guo,Y.-N., Huynh, B.-L., Lucas, M., Jia, Z., Roberts, P. A.,Lonardi, S. & Close, T. J. (2019). Seed coat pattern QTLand development in Cowpea (Vigna unguiculata [L.]Walp.). Frontiers in Plant Science, 10, 1-12. DOI: 10.3389/fpls.2019.01346

  28. Jiang, B., Obiro, W. C., Li, Y., Zhang, T. & Mu, W. (2010).Bioactivity of Proteins and Peptides from Peas (Pisumsativum, Vigna unguiculata and Cicer arietinum L.). EnY. Mine, E. Li-Chan & B. Jiang (Eds.), Bioactive Proteinsand Peptides as Functional Foods and Nutraceuticals (pp.273-287). John Wiley & Sons Ltd.

  29. Joshi, V. D., Dahake, A. P. & Suthar, A. P. (2010). Adverseeffects associated with the use of antihypertensive drugs: Anoverview. International Journal of PharmTech Research,2(1), 10-13.

  30. Katoch, R., Sharma, K., Singh, S. K. & Thakur, N. (2015).Evaluation and characterization of trypsin inhibitor fromrice bean with inhibitory activity against gut proteasesof Spodoptera litura. Zeitschrift Fur Naturforschung –Section C Journal of Biosciences, 70(11-12), 287-295.DOI: 10.1515/znc-2015-5029

  31. Kaur, H., Gill, R. S. & Kaur, S. (2020). Rice bean (Vignaumbellata Thunb. Ohwi and Ohashi) protection againstCallosobruchus maculatus F. by the presence of proteinprofile. Journal of Stored Products Research, 86, 101574.DOI: 10.1016/j.jspr.2020.101574

  32. Kim, J. Y., Park, S. C., Hwang, I., Cheong, H., Nah, J. W.,Hahm, K. S. & Park, Y. (2009). Protease inhibitors fromplants with antimicrobial activity. International Journalof Molecular Sciences, 10(6), 2860-2872. DOI: 10.3390/ijms10062860

  33. Kusumah, J., Real Hernández, L. M. & González de Mejía, E.(2020). Antioxidant potential of mung bean (Vigna radiata)albumin peptides produced by enzymatic hydrolysisanalyzed by biochemical and in silico methods. Foods,9(9), 1241. DOI: 10.3390/foods9091241

  34. Mancera-Castro, P., González-Cruz, L., Valadez-Vega, C.,Hernández-López, D., Ramírez-Medina, H., Juárez-Goiz,M. & Bernardino-Nicanor, A. (2021). Purificación ycaracterización biológica parcial de una Lectina de FrijolVaquita. Investigación y Desarrollo en Ciencia y Tecnologíade Alimentos, 6, 29-34. http://www.fcb.uanl.mx/IDCyTA/files/volume6/6/1/5.pdf

  35. Maphosa, Y. & Jideani, V. A. (2017). The role of legumes inHuman Nutrition. En M. Hueda-Chávarri (Ed.), FunctionalFood. Improve Health through Adequate Food (pp. 103-121). London: IntechOpen, England.

  36. Moharib, S. A. (2018). Anticancer activity of L-asparaginaseproduced from Vigna unguiculata. World Scientific Research,5(1), 1-12. DOI: 10.20448/journal.510.2018.51.1.1236. Mune Mune, M. A., Minka, S. R. & Henle, T. (2018).Investigation on antioxidant, angiotensin convertingenzyme and dipeptidyl peptidase IV inhibitory activity ofBambara bean protein hydrolysates. Food Chemistry, 250,162-169. DOI: 10.1016/j.foodchem.2018.01.001

  37. Munteanu, I. G. & Apetrei, C. (2021). Analytical methods usedin determining antioxidant activity: A review. InternationalJournal of Molecular Sciences, 22, 3380. DOI: 10.3390/ijms22073380

  38. Muzquiz, M., Varela, A., Burbano, C., Cuadrado, C., Guillamón,E. & Pedrosa, M. M. (2012). Bioactive compounds inlegumes: Pronutritive and antinutritive actions. Implicationsfor nutrition and health. Phytochemistry Reviews, 11(2-3),227-244. DOI: 10.1007/s11101-012-9233-9

  39. Ng, T. B. (2004). Antifungal proteins and peptides of leguminousand non-leguminous origins. Peptides, 25(7), 1215-1222.DOI: 10.1016/j.peptides.2004.03.012

  40. Ng, T. B., Wong, J. H. & Fang, E. F. (2011). Defensins andother biocidal proteins from bean seeds with medicinalactivities. Current Medicinal Chemistry, 18, 5644-5654.DOI: 10.2174/092986711798347306

  41. Pandiyan, M., Senthil, N., Anitha, M., Raveendran, M.,Sudha, M., Latha, M., Nagarajan, P., Toomoka, N. &Balasubramaninan, P. (2012). Diversity analysis of Vignasp. through morphological markers. Wudpecker Journalof Agricultural Research, 1, 335-340.

  42. Pina-Pérez, M. C. & Ferrús Pérez, M. A. (2018). Antimicrobialpotential of legume extracts against foodborne pathogens:A review. Trends in Food Science and Technology, 72,114-124. DOI: 10.1016/j.tifs.2017.12.007

  43. Rodríguez-Roque, M. J., Soliva-Fortuny, R. & Martín-Belloso, O. (2017). Methods for determining theantioxidant capacity of food constituents. En E. M. Yahia(Ed.), Fruit and Vegetable Phytochemicals: Chemistryand Human Health (2nd edition, pp. 803-816). JohnWiley & Sons, Inc.

  44. Sánchez-Chino, X., Jiménez-Martínez, C., Dávila-Ortiz, G.,Álvarez-González, I. & Madrigal-Bujaidar, E. (2015).Nutrient and nonnutrient components of legumes, and itschemopreventive activity. A review. Nutrition and Cancer,67(3), 401-410. DOI: 10.1080/01635581.2015.100472944. Schmidt, M., Arendt, E. K. & Thery, T. L. C. (2019). Isolationand characterization of the antifungal activity of the cowpeadefensin Cp-thionin II. Food Microbiology, 82, 504-514.DOI: 10.1016/j.fm.2019.03.021

  45. Sonklin, C., Alashi, M. A., Laohakunjit, N., Kerdchoechuen,O. & Aluko, L.E. (2020). Identification of antihypertensivepeptides from mung bean protein hydrolysate and theireffects in spontaneously hypertensive rats. Journalof Functional Foods, 64, 103635. DOI: 10.1016/j.jff.2019.103635

  46. Sparvoli, F., Bollini, R. & Cominelli, E. (2015). NutritionalValue. En A. M. De Ron (Ed.), Grain Legumes (pp. 291-325). New York: Springer, USA.

  47. Staško, A., Brezová, V., Biskupiˇc, S. & Mišík, V.(2007). The potential pitfalls of using 1,1-diphenyl-2-picrylhydrazyl to characterize antioxidants in mixedwater solvents. Free Radical Research, 41, 379-390. DOI:10.1080/10715760600930014

  48. Tang, S. S., Prodhan, Z. H., Biswas, S. K., Le, C. F. &Sekaran, S. D. (2018). Antimicrobial peptides fromdifferent plant sources: Isolation, characterization, andpurification. Phytochemistry, 154, 94-105. DOI: 10.1016/j.phytochem.2018.07.002

  49. Thumbrain, D., Dwarka, D., Gerrano, A. S. & Mellem, J. J.(2020). Antioxidant and apoptotic potential of proteinisolates derived from Vigna unguiculata (L.) Walp.International Journal of Food Science and Technology,55(7), 2813-2823. DOI: 10.1111/ijfs.14535

  50. Tian, G. T., Zhu, M. J., Wu, Y. Y., Liu, Q., Wang, H. X. & Ng,T. B. (2013). Purification and characterization of a proteinwith antifungal, antiproliferative, and HIV-1 reversetranscriptase inhibitory activities from small brown-eyedcowpea seeds. Biotechnology and Applied Biochemistry,64(4), 393-398. DOI: 10.1002/bab.1102

  51. Tomasetti, C., Li, L. & Vogelstein, B. (2017). Stem celldivisions, somatic mutations, cancer etiology, and cancerprevention. Science, 355(6331), 1330-1334. DOI: 10.1126/science.aaf9011

  52. Tomooka, N. (2009). The origins of rice bean (Vigna umbellata)and azuki bean (Vigna angularis): The evolution of twolesser-known Asian beans. En T. Akimichi (Ed.), Anillustrated eco-history of the Mekong River Basin (pp.33-35). White Lotus Co. Ltd.

  53. Tomooka, N., Kaga, A., Isemura, T., Vaughan, D., Srinives, P.,Somta, P., Thadavong, S., Bounphanousay, C., Kanyavong,K., Inthapanya, P., Pandiyan, M., Senthil, N., Ramamoorthi,N., Jaiwal, P. K., Jing, T., Umezawa, K. & Yokoyama,T. (2011). Vigna Genetic Resources. En N. Tomooka &D. Vaughan, The 14th NIAS International Workshop onGenetic Resources – Genetic Resources and ComparativeGenomics of Legumes (Glycine and Vigna) (pp. 11-21).Tsukuba: National Institute of Agrobiological Science.

  54. Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter,N. R., Prabhakaran, D., Ramirez, A., Schlaich, M.,Stergiou, G. S., Tomaszewski, M., Wainford, R. D.,Williams, B. & Schutte, A. E. (2020). 2020 InternationalSociety of Hypertension Global Hypertension PracticeGuidelines. Hypertension, 75, 1334-1357. DOI: 10.1161/HYPERTENSIONAHA.120.15026

  55. Wang, F., Huang, L., Yuan, X., Zhang, X., Guo, L., Xue,C. & Chen, X. (2021). Nutritional, phytochemical andantioxidant properties of 24 mung bean (Vigna radiate L.)genotypes. Food Production, Processing and Nutrition,3(28), 1-12. DOI: 10.1186/s43014-021-00073-x

  56. Wang, S., Lin, J., Ye, M., Ng, T. B., Rao, P. & Ye, X. (2006).Isolation and characterization of a novel mung beanprotease inhibitor with antipathogenic and anti-proliferativeactivities. Peptides, 27(12), 3129-3136. DOI: 10.1016/j.peptides.2006.07.013

  57. Wang, S. Y., Wu, J. H., Ng, T. B., Ye, X. Y. & Rao, P. F. (2004).A non-specific lipid transfer protein with antifungal andantibacterial activities from the mung bean. Peptides, 25(8),1235-1242. DOI: 10.1016/j.bbrc.2004.12.077

  58. Wong, J. H. & Ng, T. B. (2003). Purification of a trypsin-stablelectin with antiproliferative and HIV-1 reverse transcriptaseinhibitory activity. Biochemical and Biophysical ResearchCommunications, 301(2), 545-550. DOI: 10.1016/S0006-291X(02)03080-2

  59. Wong, J. H., Ng, T. B., Wang, H., Cheung, R. C. F., Ng,C. C. W., Ye, X., Yang, J., Liu, F., Ling, C., Chan, K.,Ye, X. & Chan, W. Y. (2019). Antifungal proteins withantiproliferative activity on cancer cells and HIV-1 enzymeinhibitory activity from medicinal plants and medicinalfungi. Current Protein & Peptide Science, 20(3), 265-276.DOI: 10.2174/1389203719666180613085704

  60. Xu, L., Li, Y., Dai, Y. & Peng, J. (2018). Natural products forthe treatment of type 2 diabetes mellitus: Pharmacologyand mechanisms. Pharmacological Research, 130, 451-465. DOI: 10.1016/j.phrs.2018.01.015

  61. Ye, X. & Ng, T. B. (2005). A chitinase with antifungal activityfrom the mung bean. Protein Expression and Purification,40(2), 230-236. DOI: 10.1016/j.pep.2004.06.032

  62. Ye, X. Y. & Ng, T. B. (2001). Isolation of unguilin, acyclophilin-like protein with antimitogenic, antiviral,and antifungal activities, from black-eyed pea.Journal of Protein Chemistry, 20(5), 353-359. DOI:10.1023/A:1012272518778

  63. Ye, X. Y. & Ng, T. B. (2002a). Delandin, a chitinase-like proteinwith antifungal, HIV-1 reverse transcriptase inhibitoryand mitogenic activities from the rice bean Delandiaumbellata. Protein Expression and Purification, 24(3),524-529. DOI: 10.1006/prep.2001.1596

  64. Ye, X. Y. & Ng, T. B. (2002b). Purification of angularina, anovel antifungal peptide from Adzuki beans. Journal ofPeptide Science, 8(3), 101-106. DOI: 10.1002/psc.372

  65. Ye, X. Y., Wang, H. X. & Ng, T. B. (2000). Structurally dissimilarproteins with antiviral and antifungal potency from cowpea(Vigna unguiculata) seeds. Life Sciences, 67(26), 3199-3207. DOI: 10.1016/s0024-3205(00)00905-x

  66. Zahedmehr, A. (2018). Hypertension. En M. Maleki, A.Alizadehasl & M. Haghjoo (Eds.), Practical Cardiology(pp. 291-302). Elsevier Inc.

  67. Zitvogel, L., Pietrocola, F. & Kroemer, G. (2017). Nutrition,inflammation and cancer. Nature Immunology, 18(8), 843-850. DOI: 10.1038/ni.3754




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