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2024, Number 4

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Acta Med 2024; 22 (4)

Review of the use of platelet-rich plasma in the treatment of fractures in orthopedics and regenerative medicine

García LR, Olivé MA, Reyes MME, Rubio GMA
Full text How to cite this article 10.35366/117517

DOI

DOI: 10.35366/117517
URL: https://dx.doi.org/10.35366/117517

Language: Spanish
References: 11
Page: 286-289
PDF size: 203.97 Kb.


Key words:

pseudarthrosis, bone consolidation, fibroblast growth factor, platelet-derived angiogenesis factor, platelet-derived growth factor.

ABSTRACT

Platelet-rich plasma (PRP) is an autologous infiltrate extracted from the patient's blood to address various medical treatments. Being autologous, it does not cause immunoreactivity in patients and is a non-invasive procedure. Evidence suggests that PRP accelerates tissue regeneration by activating osteoblastic genes with mesenchymal stem cells, thus promoting bone regeneration and consolidation. This is why its results are being studied in cases of delayed bone fractures as a complement to immobilization, speeding up the bone regeneration process and improving the quality of life for patients.


REFERENCES

  1. Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: a review and author's perspective. J Cutan Aesthet Surg. 2014; 7 (4): 189-197.

  2. Gómez-Martín B, Sánchez-Rodríguez R, Martínez Nova A, Escamilla-Martínez E. Tratamiento de una fractura del proceso anterior del calcáneo con plasma rico en plaquetas: caso clínico. Rev Esp Podol. 2019; 30 (2): 109-112.

  3. Say F, Turkeli E, Bulbul M. Is platelet-rich plasma injection an effective choice in cases of non-union? Acta Chir Orthop Traumatol Cech. 2014; 81 (5): 340-345.

  4. Zhang N, Wu YP, Qian SJ, Teng C, Chen S, Li H. Research progress in the mechanism of effect of PRP in bone deficiency healing. ScientificWorldJournal. 2013; 2013: 134582. doi: 10.1155/2013/134582.

  5. Zhao Y, Zhang H, Li N, Li J, Zhang L. Chronic pain after bone fracture: current insights into molecular mechanisms and therapeutic strategies. Brain Sci. 2022; 12 (8): 1056. doi: 10.3390/brainsci12081056.

  6. Malhotra R, Kumar V, Garg B, Singh R, Jain V, Coshic P et al. Role of autologous platelet-rich plasma in treatment of long-bone nonunions: a prospective study. Musculoskelet Surg. 2015; 99 (3): 243-248.

  7. Van Lieshout EMM, Den Hartog D. Effect of platelet-rich plasma on fracture healing. Injury. 2021; 52 Suppl 2: S58-S66.

  8. Kumar V. Robins y Contran. Fracturas de huesos: definición y proceso de curación en tres pasos [Internet]. 10° edición [citado 15 agosto 2023]. Disponible en: https://www.elsevier.com/es-es/connect/medicina/patologia-anatomia-huesos-como-se-curan-las-fracturas

  9. Ballester M. Tiempo de recuperación de una fractura de tobillo [Internet].2022 [Citado 29 agosto 2023]. Disponible en: https://www.cirugiapie.com/blog/tiempo-de-recuperacion-de-una-fractura-de-tobillo

  10. Colón15. Uso de plasma rico en plaquetas en traumatología [Internet]. Colón15 Sevilla - Centro Médico Avanzado; 2019 [citado agosto de 2023]. Disponible en: https://colon15.com/traumatologia/traumatologia-plasma-rico-plaquetas/#target-2

  11. Andersen C, Wragg NM, Shariatzadeh M, Wilson SL. The use of platelet-rich plasma (PRP) for the management of non-union fractures. Curr Osteoporos Rep. 2021; 19 (1): 1-14. doi: 10.1007/s11914-020-00643-x.




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