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ISSN 1990-7990 (Electronic)
Revista Universitaria

2022, Number 2

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Universidad Médica Pinareña 2022; 18 (2)

Neurological manifestations in patients with COVID-19

Aguiar-González AM, Roque-Pérez L, Morejón-Roblejo M

Language: Spanish
References: 30
Page: 1-10
PDF size: 512.98 Kb.


ABSTRACT

Introduction: COVID-19 pandemic represents a challenge for healthcare systems, due to the impact on different systems, such as respiratory, cardiovascular and nervous systems.
Objective: to describe the neurological manifestations in patients with COVID-19.
Methods: a search for information was carried out in the PubMed/Medline, SciELO, EBSCO, Lilacs and Scopus databases. A search strategy was applied by combining terms and using Boolean operators. Thirty references were chosen.
Results: olfactory nerves and invasion of peripheral nerve terminals are suggested as routes of entry; the presence of severe neural symptoms associated with lesions of other organs and cytokine storm is also described. Headache was the most common neurological manifestation in patients with COVID-19, and rhabdomyolysis, acute hemorrhagic necrotizing encephalopathy, Guillain Barré syndrome, meningitis and encephalitis are rare neurological entities. In Guillain Barré syndrome, the literature suggests both a post infectious and para-infectious pattern.
Conclusions: COVID-19 is associated with different neurological manifestations, including headache, dizziness, vertigo, vomiting, and alterations of consciousness, stroke and others not so frequent. These symptoms as a whole should be evaluated by healthcare personnel, with a view to their rapid detection and management, in order to guarantee the disappearance of sequelae that reduce the quality of life of patients, as well as to reduce the associated mortality records.


REFERENCES

  1. Espinosa-Brito A. Acompañando la marcha de la pandemia de COVID-19. Una mirada desde Cienfuegos. Medisur [Internet]. 2020 [cited 08/02/2021]; 18(3): [aprox. 8 p.]. Available in: http://medisur.sld.cu/index.php/medisur/article/view/4726

  2. Giralt-Herrera A, Rojas-Velázquez JM, Leiva-Enríquez J. Relación entre COVID-19 e Hipertensión Arterial. Rev haban cienc méd [Internet]. 2020 [cited 08/02/2021]; 19(2):e3246. Available in: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3246

  3. Moreno-Zambrano D, Arévalo-Mora M, Freire-Bonifacini A, García-Santibanez R, Santibañez-Vásquez R, Manifestaciones Neurológicas Asociadas a la Infección Por SARS-CoV-2: Una Neuro-Revisión de COVID-19, Rev. Ecuat. Neurol. [Internet] 2020. [cited 08/02/2021]; 29(1): 1-10. Available in: http://revecuatneurol.com/wp-content/uploads/2020/05/2631-2581-rneuro-29-01-00115.pdf

  4. Pérez Abreu MR, Gómez Tejeda JJ, Dieguez Guach RA. Características clínico-epidemiológicas de la COVID-19. Rev haban cienc méd [Internet]. 2020 [cited 08/02/2021]; 19(2):e3254. Available in: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3254/2505

  5. Candelaria-Brito JC, Díaz-Cruz SA, Acosta-Pérez DM, Labrador-Mazón O, Rodríguez-Méndez A. Estrategia intervencionista dirigida a la prevención y control de la COVID-19 en Consolación del Sur. Rev Ciencias Médicas [Internet]. 2020 [cited 08/02/2021]; 24(3):e4495. Available in: http://revcmpinar.sld.cu/index.php/publicaciones/article/view/4495

  6. World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard [Internet]. Ginebra: World Health Organization; 2021 [cited 08/02/2021]. Available in: https://www.who.int/publications-detail/clinicalmanagement-of-severe-acute-respiratory-infectionwhen-novel-coronavirus-(ncov)-infection-issuspected

  7. Gómez-Tejeda JJ, Dieguez-Guach RA, Pérez-Abreu MR. Alternativas terapéuticas para el manejo de la COVID-19. Rev haban cienc méd [Internet]. 2020 [cited 08/02/2021]; 19(Supl.): e3328. Available in: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3328

  8. Centro Nacional de Información de Ciencias Médicas. Infecciones por coronavirus. Nota informativa sobre la COVID-19 en Cuba: 7 de febrero [Internet]. La Habana: Centro Nacional de Información de Ciencias Médicas; 2021 [cited 08/02/2021]. Available in: https://temas.sld.cu/coronavirus/2021/2/8/nota-informativa-sobre-la-covid-19-en-cuba-8-de-febrero/

  9. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet [Internet]. 2020 [cited 08/02/2021]; 395(10223):497-506. Available in: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext?

  10. Cheng VC, Lau SK, Woo PC, Yuen KY. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev. [Internet]. 2007 [cited 08/02/2021]; 20(4):660–694. Available in: http://www.doi:10.1128/CMR.00023-07

  11. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. [Internet]. 2020 [cited 08/02/2021]; 77(6): 683-690. Available in: https://jamanetwork.com/journalsjamaneurology/fullarticle/2764549

  12. Rodriguez Morales AJ, Cardona Ospina JA, Gutiérrez Ocampo E, Vallamizar Peña R, Holguín Rivera T,Escalera Antenazana JA, y col. Clinical, laboratory and imaging features of COVID-19: A systematic review and metaanalysis. Travel Med Infect Dis. [Internet]. 2020 [cited 08/02/2021]; Available in: http://www.doi:10.1016/j. tmaid.2020.101623

  13. Aldámiz-Echevarría Lois MT, Aledo Serrano A, Hernández González-Monje M, Catalán Alfonso P, Díez Romero C, Martínez Hernández E, et al. Manual COVID-19 para el neurólogo general. Madrid: Ediciones SEN; 2020

  14. Schwartz DA. Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med [Internet]. 2020 [cited 08/02/2021]; 144:799-805. Available in: https://pubmed.ncbi.nlm.nih.gov/32180426/

  15. Manji H, S Carr A, Brownlee WJ, Lunn MP, Neurology in the time of COVID-19, J Neurol Neurosurg Psychiatry [Internet]. 2020. [cited 08/02/2021]. 91(6); 10-11 . Available in: https://jnnp.bmj.com/content/jnnp/91/6/568.full.pdf

  16. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel, Griffith B. COVID-19—asociated acute hemorragic necrotizing encephalopathy: CT and MRI features. Radiology [Internet]. 2020 [cited 08/02/2021]; 83(2): 127-133. Available in: https://doi.org/10.20453/rnp.v83i2.3756

  17. Ashutosh K, Vikas P, Pranav P, Muneeb AF, Pavan K, Chiman K, et al. Posibles rutas de invasión en el cerebro del SARS-CoV-2: en el contexto de síntomas neurológicos en pacientes con covid-19. Rev de investigaciones neurocientíficas. [Internet]. 2020 [cited 08/02/2021]; 98: 2376-2383. Available in: https://publons.com/publon/10.1002/jnr.24717

  18. Xu XW, Wu X-X, Jiang X-G, Xu H-J, Ying L-J, Ma C-L, y col. Clinical fidings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. [Internet]. 2020 [cited 08/02/2021]; 19: 368. Available in: https://pubmed.ncbi.nlm.nih.gov/32075786

  19. Zhang P. Invited Commentary: Be cautious of comorbidities of COVID-19 and neurologic diseases. Neurol Blogs. [Internet]. 2020 [cited 08/02/2021] Available in: https://blogs.neurology.org/global/invited-commentarybe-cautious-of-comorbidities-of-covid-19-and-neurologicdiseases/

  20. Guan WJ, Ni ZY, Hu Y, Liang WH, Ph D, Yu Hu MD, y col. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. [Internet]. 2020. [cited 08/02/2021]; 382: 1708-1720. Available in: https://pubmed.ncbi.nlm.nih.gov/32109013

  21. Li Y, Wang M, Zhou Y, Chang J, Xian Y, Mao L, y col. Acute Cerebrovascular Disease Following COVID-19: A Single Center, Retrospective, Observational Study. [Internet]. 2020. [cited 08/02/2021]: 5(3): 279-284. Available in: http://dx.doi.org/10.2139/ssrn.3550025

  22. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol [Internet]. 2020 [cited 08/02/2021]; 92(6): 552-555. Available in: https://doi.org/10.1002/jmv.25728

  23. Jin M, Tong Q. Rhabdomyolysis as potential late complication associated with COVID-19. Emerg Infect Dis. [Internet] 2020. [cited 08/02/2021]; 26(7): 1618-1620. Available in: https://doi.org/10.3201/eid2607.200445

  24. Zhao H, Shen D, Zhou H, Liu J, Chen S. Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Lancet Neurol. [Internet]. 2020 [cited 08/02/2021]; 19(5): 383-4. Available in: https://doi.org/10.1016/S1474-4422(20)30109-5

  25. Moriguchi T, Harii N, Goto J,Harada D, Sugwara H, Takamino J, y col. A fisrt Case of Meningitis/ Encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis [Internet]. 2020 [cited 08/02/2021]; 94: 55-58. Available in: https://reader.elsevier.com/reader/sd/pii/S1201971220301958?token=BB69B2C364405430A881A7A1C5FEC519E413F7DE413598E3A971A36C6B605B7F842EA12752A961A307C0DF6EF70178AE&originRegion=us-east-1&originCreation=20211018194935

  26. Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, y col. Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med [Internet]. 2020 [cited 08/02/2021]; 382(23): 2268-2270. Available in: https://www.nejm.org/doi/full/10.1056/NEJMc2008597

  27. Filatov A, Sharma P, Hindi F, Esponosa PS. Neurological complications of coronavirus (COVID-19): encephalopathy. Cureus. [Internet]. 2020 [cited 08/02/2021]; 12(3): e7352. Available in: https://doi.org/10.7759/cereus.7352

  28. Lechien JR, Chisea-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European Study. Eur Arch Otorhinolaryngol [Internet]. 2020 [cited 08/02/2021]; 277(8):2251-2261. Available in: https://pubmed.ncbi.nlm.nih.gov/32253535/

  29. Sedaghat Z, Karimi N. Guillain Barre syndrome associated with COVID-19 infection: a case report. J Clin Neurosci. [Internet]. 2020 [cited 08/02/2021]. 76: 233–235. Available in: https://pubmed.ncbi.nlm.nih.gov/32312628

  30. Barrachina Esteve O. Domínguez Palau A. Hidalgo Torrico I. Viguera Martinez ML. Síndrome de Guillain-Barré como forma de presentación de la infección por SARS-CoV-2. Rev Neurol. [Internet]. 2020 [cited 08/02/2021]; 3(9): 710-712. Available in: https://www.elsevier.es/es-revista-neurologia-295-articulo-sindrome-guillain-barre-como-forma-presentacion-S0213485320302085




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