Rico-Rubio GE, Peña-Corona Villanueva A, Rivero-Martínez JA, Scull-Verduzco L

Language: Spanish
References: 9
Page: 250-254
PDF size: 231.31 Kb.

ABSTRACT

Mycetoma is a chronic granulomatous infection of the skin and subcutaneous tissue. In Mexico, 92% of cases are actinomycetoma, caused mainly by Nocardia brasilensis (78%). We report a 32-year-old in 28 weeks pregnant woman, presented with one year history of mycetoma on the dorsum of the left foot. She worsened during pregnancy. The biopsy confirmed actinomycetoma by the presence of Nocardia grains. She received an initial treatment with amoxicillin/clavulanic acid without improvement, presenting extension of the lesion. Cure was observed after delivery and six months of therapy with trimethoprim/sulfamethoxazole and rifampicin. Treatment of actinomycetoma during pregnancy is a challenge due to the rapid progression of the infection and limitation with prescription of antimicrobials.

REFERENCES

1. Verma P y Jha A, Mycetoma: reviewing a neglected disease,Clin Exp Dermatol 2019; 44(2):123-9.

2. Emery D y Denning DW, The global distribution of actinomycetomaand eumycetoma, plos Negl Trop Dis 2020; 14(9).

3. Hao X, Cognetti M, Burch-Smith R, Mejía EO y Mirkin G, Mycetoma:development of diagnosis and treatment, J Fungi (Basilea)2022; 8(7):743.

4. Agarwal P, Jagati A, Rathod SP, Kalra K, Patel S y Chaudhari M,Clinical features of mycetoma and the appropriate treatment options,Res Rep Trop Med 2021; 12:173-9.

5. Robinson DP y Klein SL, Pregnancy and pregnancy-associatedhormones alter immune responses and disease pathogenesis,Horm Behav 2012; 62(3):263-71. doi: 10.1016/j.yhbeh.2012.02.023.Epub 2012 Mar 3. pmid: 22406114; pmcid: pmc3376705.

6. Sampaio FM, Gutierrez Galhardo MC, De Farias Cardoso R, DeOliveira Coelho JM, Rosandiski Lyra M y Francesconi do ValleAC, Eumycetoma on the foot caused by Madurella mycetomatis:amputation after significant worsening during pregnancy,Acta Derm Venereol 2015; 95:374-5.

7. Hay Roderick J, Mycetoma, mycoses and pregnancy, ActaDerm Venereol 2015; 95:259-60.

8. Yeh I y Dhanireddy S, Madura foot caused by Actinomaduramadurae in a pregnant woman, Arch Dermatol 2010; 146(10):1189-90.

9. Espinosa S, Perales D, Ponce RM, Buitrón-García R y BonifazA, Actinomicetoma en el embarazo. Reporte de un caso: ¿quéhacer y cómo tratarlo?, Ginecol Obstet Mex 2017; 85(3):190-5.