Leyva MKI, Ángeles GU

Language: Spanish
References: 10
Page: 96-104
PDF size: 164.5 Kb.

ABSTRACT

Background. Infections caused by antimicrobial-resistant (AMR) bacteria can lead to health complications such as prolonged hospitalizations, treatment failures, higher medical costs, and increased mortality.
Objective. To determine whether amr to empiric therapy alone increases the risk of death in patients with healthcare-associated infections (HAIS).
Materials and methods. Case-control study in the Hospital de Especialidades Centro Médico Nacional La Raza in patients who during the period of 2020 and 2021 were hospitalized and developed an HAI by any microorganism with AMR. The uni-, bi- and multivariate analysis of the results was performed using the SPSS v.25 statistical program and will be presented in tables and graphs. (¿¿??).
Results. A total of 266 cases and 266 controls were included. The sex distribution in the cases was 49.6% men and 50.38% women, in the control group the proportion of men was higher 55.6% compared to women 44.36%. In the paired bivariate analysis it was identified that patients with UTI had 2.19 times more risk compared to those with any other HAI (RAM 2.19, 95% CI 1.36-3.55, p ‹0.0001). In relation to death, the proportion was higher in controls 61.43% (n = 137) compared to cases 38.57% (n = 86).
Conclusions. Although this study did not prove an association between AMR and mortality in patients with hais, there is still much to be explored in the health field in relation to this AMR-HAI duo.

REFERENCES

1. Cantón R, Loza E, Aznar J, Castillo FJ, Cercenado E,Fraile-Ribot PA, et al. “Monitoring the antimicrobialsusceptibility of gram-negative organisms involved inintra-abdominal and urinary tract infections recoveredduring the smart study (Spain, 2016 and 2017)”. Rev Españolade Quimioterapia 2019; 32 (2):145-55.

2. General. C de S. ACUERDO por el que se declara la obligatoriedadde la Estrategia Nacional de Acción contra laResistencia a los Antimicrobianos. 2018;

3. Niederman MS, Baron RM, Bouadma L, Calandra T, DanemanN, DeWaele J, et al. “Initial antimicrobial managementof sepsis”. Crit Care [Internet]. 2021;25(1):1-11. Availablefrom: https://doi.org/10.1186/s13054-021-03736-w

4. Strich JR, Heil EL, Masur H. “Considerations for EmpiricAntimicrobial Therapy in Sepsis and Septic Shock in anEra of Antimicrobial Resistance”. Rev J Infect Dis. 2020;222 (Suppl 2):119-31.

5. Jain N, Jansone I, Obidenova T, Simanis R, Meisters J,Straupmane D, et al. “Antimicrobial resistance in nosocomialisolates of gram-negative bacteria: Public healthimplications in the latvian context”. Rev Antibiotics (Basel).2021;10 (7): 791.

6. Rodr M, Miranda-novales G, Flores-moreno K, Le SP de.“The interrelationships between antimicrobial resistance,COVID-19, past, and future pandemics”. Rev J InfectPublic Health. 2020; 14 (1): 53-60.

7. Elmahi OKO, Uakkas S, Olalekan BY, Damilola IA, AdedejiOJ, Hasan MM, et al. “Antimicrobial resistance andone health in the post COVID-19 era: What should healthstudents learn? “ Rev Antimicrob Resist Infect Control[Internet]. 2022; 11 (1): 1-4. Available from: https://doi.org/10.1186/s13756-022-01099-7

8. Chitungo I, Dzinamarira T, Nyazika TK, Herrera H, MusukaG, Murewanhema G. “Inappropriate Antibiotic Usein Zimbabwe in the COVID-19 Era: A Perfect Recipe forAntimicrobial Resistance”. Rev Antibiotics (Basel). 2022;11 (2): 1-9.

9. Alali WQ, Alfouzan W, Dhar R. “Prevalence of antimicrobialresistance in Gram-negative clinical isolates froma major secondary hospital in Kuwait: a retrospectivedescriptive study”. Rev Germs. 2021;11 (4): 498-511.

10. Uc-Cachón AH, Gracida-Osorno C, Luna-Chi IG, Jiménez-Guillermo JG, Molina-Salinas GM. “High prevalenceof antimicrobial resistance among gram-negativeisolated bacilli in intensive care units at a tertiary-carehospital in Yucatán Mexico”. Rev Medicina (Lithuania).2019; 55 (9): 588.