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2024, Number 1

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Rev Hematol Mex 2024; 25 (1)

Pernicious anemia: Effects on the health of older adults and treatment

Morales CL, Cardoso RMC

Language: Spanish
References: 33
Page: 18-30
PDF size: 446.71 Kb.


ABSTRACT

Background: Human aging is a gradual and adaptive process characterized by a relative decrease in the homeostatic response as a consequence of a series of morphological, physiological, biochemical and psychological modifications, caused by changes immanent in age. The objective of this article is to analyze the effects and different treatments prescribed in pernicious anemia in older adults.
Materials and Methods: A systematic search of original articles was carried out according to the indications proposed in the PRISMA guide (Preferred Reporting Items for Systematic reviews and Meta-Analyses), the databases consulted were PubMed, MedicLatina, Nutrition Reference Center, Sage Journals, Apa PsycNet, Eric and Food Science Source, with the Boolean AND and OR computers, under the keywords Pernicious anemia, Effects, Treatment and Older adults, based on the MeSh (Medical Subject Heading) and DeCS (Descriptors of Health Sciences). The searches were in Spanish and English, during May and June 2021.
Results: Four hundred fifty-eight papers were found, 379 of these were removed due to non-inclusion criteria, inconsistencies, articles not available in full text and other reasons (invalid instruments); 30 papers were included in total and analyzed in this study. The effects of pernicious anemia in older adults found in these studies were: mild cognitive deficit and dementia syndrome, depression, neoplastic complications, myelophthisic anemia and venous thromboembolism.
Conclusions: Various factors involved in affecting the performance of older adults are highlighted, especially when they are associated with cognitive deficiency that result in significant disability and loss in the quality of life.


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