Cinética de producción de H2S por la Cistationina &#946;-sintasa de Trypanosoma Cruzi

Jerónimo Gonce; César Pastrana-Pineda; Noé López; Rusely Encalada; Josué Arturo Velázquez-Moyado; Javier A Belmont-Díaz

2024, Number 3

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Rev Educ Bioquimica 2024; 43 (3)

Cinética de producción de H₂S por la Cistationina β-sintasa de Trypanosoma Cruzi

Gonce J, Pastrana-Pineda C, López N, Encalada R, Velázquez-Moyado JA, Belmont-Díaz JA

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Language: Spanish
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Page: 184-188
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ABSTRACT

The canonical cystathionine β-synthase (CBS) reaction consists of a β- substitution where the thiol group of homocysteine replaces the hydroxyl group of serine to produce cystathionine. This reaction constitutes the first step in the synthesis of cysteine through the reverse transsulfuration pathway. In addition to its canonical reaction, CBS can catalyze other β-substitution reactions, which may play an important role in cellular physiology. One of the most relevant non-canonical CBS reactions is the production of sulfide (H₂S) from the condensation of two cysteine molecules. In the present work we delve into the reasons that explain the promiscuity of the CBS substrates and compares the kinetics of the canonical reaction with the kinetics of the production of H₂S in the recombinant CBS of Trypanosoma cruzi.