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2024, Number 5

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Acta Med 2024; 22 (5)

Clinical correlation of multipathogenic polymerase chain reaction compared to blood culture in patients with sepsis

Núñez HJC, Nieves PCA, Ceballos VTBG, Figueroa CMÁ, Gerónimo GN, Díaz GEJ, Rodríguez WFL

Language: Spanish
References: 14
Page: 366-370
PDF size: 219.51 Kb.


ABSTRACT

Introduction: sepsis is a severe medical condition with high mortality and diagnostic challenges, particularly with the limitations of blood cultures, delaying vital treatments, and increasing risks of antibiotic resistance. The PCR-based sepsis panel promises rapid and accurate identification of pathogens and is effective in fungal infections and antibiotic resistance. Objective: to compare the efficacy of multipathogen PCR versus blood cultures in patients with sepsis at "Hospital Angeles Pedregal". Material and methods: the research, carried out between 2021 and 2022, focused on patients with sepsis, proposing hypotheses on the correlation between both diagnostic techniques. The observational and historical design did not include a control group, opting for non-random sampling and statistical analysis of detailed clinical data under strict confidentiality measures and ethical supervision. Results: 56 participants were included, predominantly men, with a mean age of 62 and various comorbidities. The correlation between PCR and blood cultures was significant (p = 0.035), although other statistical analyses showed mixed results. Conclusion: the study highlights the potential of multipathogen PCR in sepsis diagnosis, advocating its integration with established practices to improve personalized care and patient outcomes.


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