González-Piñón DP, Pedregón-Flores F

Language: Spanish
References: 10
Page: 85-89
PDF size: 423.90 Kb.

ABSTRACT

Introduction: dexmedetomidine is an alpha-2 adrenergic drug with analgesic and sedative properties. It is administered intranasally, as an alternative for the management of immediate post-surgical pain, in patients undergoing abdominal hysterectomy. Objective: to determine the postoperative analgesic effectiveness of premedication with dexmedetomidine intranasally at a dose of 1 μg/kg/weight thirty minutes before abdominal hysterectomy. Material and methods: clinical trial, controlled, randomized. At the Gynecology and Obstetrics Hospital. 50 patients scheduled for abdominal hysterectomy were included. The first group was administered intranasal dexmedetomidine at a dose of 1 mg/kg, the second group was not administered. During the post-surgical period, an assessment is carried out with the analog numerical scale (ENA) every 5 minutes. Results: in the premedicated group, 22 patients reported mild pain, one moderate and two severe. In the group without premedication, 12 patients reported mild pain, seven reported moderate pain, and six reported severe pain. The group premedicated with dexmedetomidine obtained a χ² with a critical value of 9.441, the result presented bilateral asymptotic significance of 0.009, affirming with 95% confidence and with a statistically significant result. Conclusions: decrease in pain in patients premedicated with dexmedetomidine.

REFERENCES

1. Bertini L. Pain free hospital: organisation aspects. Minerva Anestesiol. 2001;67:181-186.

2. Moreno CB. Fisiopatología del dolor clínico. Asociación Colombiana de Neurología. 2004;9-21.

3. Plaghki L, Mouraux A, Le Bars D. Fisiología del dolor. EMC Kinesioterapia- Medicina Física. 2018.

4. Ladín A. Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán". Obtenido de Journal Club: La escalera analgésica de la OMS ¿Activa o Arcaica? 2021. Disponible en: http://www.dolorpaliativos.org/jc02.asp

5. Romera OM, Chamorro JC, Lipperheide VI, Fernández SI. Indicaciones de la dexmedetomidina en las tendencias actuales de sedoanalgesia en el paciente crítico. Medicina Intensiva. 2014;38:41-48.

6. Alegre AP, Trujillo RVF. Dexmedetomidina intranasal en sedación paraginecoobstetricia. Gac Med Bol. 2020;43:28-33.

7. Sattari H, Hashemian M, Noroozi M, Khaloueipour. Evaluation of the effect of dexmedetomidine on hemodynamic changes and recovery time in patients undergoing dilatation and curettage. [In press] Med Argent. 2019;105:1-3.

8. Quinde CP. Dolor postoperatorio factores de riesgo y abordaje. Med Leg Costa Rica. 2017;34:254-264.

9. Linares SB, García CMA, Ramírez CIL, Guerrero RJF, Botello BI, Monroy TR, et al. Medicación preanestésica con dexmedetomidina intranasal y midazolam oral como ansiolítico. Un ensayo clínico. anales de pediatría. 2014;81:226-231.

10. García PCE, Ramos GJ. Analgesia posoperatoria con dexmedetomidina intranasal en cirugía laparoscópica diagnóstica. Interciencia. 2010;17-22.